Wow what is your point buddy? Obviously their are fillers and binders in the pill, like I expect it to be pure Oxymorphone Hcl salt or something? of course not, everybody knows that pills contain fillers..
and OF COURSE the BA numbers aren't fucking set in stone, who said they were?! They are there to give you a rough idea of the amount of drug that will be absorbed through a certain route of administration. Sry but telling me that BA's are subject to change is pretty much a given, and YES there are many factors that can effect the BA like stomach contents, snorting tehnique, etc.
Wow. I'm not sure what set you off, all I did was post some information.
You said the BA percentages are useless.
Don't misquote me. I said INTRANASAL percentages are useless, because they are. And then I proceeded to explain why.
Anyone with common sense would know that the BA percentages are vital for a site that is focused on Harm Reduction, you do know thats what this site is all about right?
Everything I've posted is for the sake of harm reduction. I think that's pretty obvious to everyone else.
Why would BA percentages be important in Harm Reduction? Ill give you an example. lets use Oxymorphone as an example.
Your example, once again, does not take volume into consideration. My "point" is simple:
1. If you snort 40mg of Opana...
2. Assume 50% of the pill goes into your stomach
3. Therefore 20mg is consumed orally (20mg x 10% oral BA = 2mg absorbed)
4. And 20mg is consumed intranasally (20mg x 40% nasal BA = 8mg absorbed)
5. For a total absorption of 2 + 8 = 10mg.
Which is substantially lower than the predicted intranasal absorption of 40mg X 40% = 16mg. The more you snort, the worse it gets:
1. If you snort 80mg of Opana...
2. Assume 75% of the pill now goes into your stomach (because your nose can still only retain 20mg)
3. Therefore 60mg is consumed orally (60mg x 10% oral BA = 6mg absorbed)
4. And 20mg is consumed intranasally (20mg x 40% nasal BA = 8mg absorbed)
5. For a total absorption of 6 + 8 = 14mg.
Which is substantially lower than the predicted intranasal absorption of 80mg X 40% = 32mg. If you snort a tiny little bit of Opana, say, a quarter of a pill, then I agree that it would be absorbed primarily through the nose, and then you can use the blanket intranasal BA figure.
From my experience, there's a ceiling effect with snorting Dilaudid/Opana. Once your tolerance rises above about a 2-pill dose (10mg Opana/8mg Dilaudid), then you just can't snort enough to get high anymore. Your sinuses will start to cake up with inert powder, and you'll feel it build up in your lungs. You can cough it up and feel the pill "mud" in your throat. Snorting 4 pills, for example, doesn't feel any different than snorting 2 pills. I can only assume it's because a bulk of the powder ends up taking the GI route, where it is scarcely (and slowly) absorbed.
For the record, from my experience at least, snorting a 10mg Opana is roughly equivalent to snorting an 8mg Dilaudid, which is roughly equivalent to snorting 40mg of Oxycontin (half an 80, not a single 40). Snorting 2 pills of either Opana/Dilaudid was not twice as strong as snorting 1 pill. And snorting 3 pills felt exactly the same as snorting 2 pills. Diminishing returns at it's worst.
I really wish I knew what the lung absorption rate was. In fact, is that factored into the intranasal figures? How do they even come up with these numbers? I've always assumed that they actually had patients insufflate the drugs, then they tested the blood after a period of time to determine the drug/plasma levels. If that's the case, then "intranasal" is a bit of a misnomer, because it will in fact include lung absorption.