-
OD Moderators: Keif’ Richards | negrogesic
Opioids Oxymorphazone? Anybody know anything about it?
- Thread starter pheungies
- Start date
brighton
Bluelighter
Sounds interesting. I thought you had just misspelled oxymorphone.
What exactly did you want to know?
What exactly did you want to know?
TheLostBoys
Bluelighter
Doesnt google have anything on it?
NeighborhoodThreat
Bluelight Crew
There's a wikipedia article but it doesn't have much...
tokenname
Bluelighter
- Joined
- Mar 1, 2012
- Messages
- 2,056
Found this comparing it to oxymorphone..thanks google! I was interested as well.
"Acutely, oxymorphazone (ED50, 0.6 mg/kg, sc) was approximately half as potent as oxymorphone (ED50, 0.3 mg/kg, sc) in the tail-flick assay. Administered at their ED50 doses, both compounds had the same durations of action. As the doses of drug were increased, however, the time course of oxymorphazone's analgesia became far more prolonged than that of oxymorphone. Following the administration of oxymorphazone (100 mg/kg), over 50% of the mice remained analgesic for greater than 24 hr, as opposed to none of the mice given oxymorphone (100 mg/kg). Oxymorphazone was far more potent intraventricularly (icv) than systemically. Fifty percent of the mice remained analgesic for greater than 20 hr following the injection of 40 micrograms/mouse (icv), whereas no mice remained analgesic after 20 hr following doses of oxymorphone as high as 50 micrograms/mouse (icv). These long-lasting analgesic actions of oxymorphazone could not be easily explained on pharmacokinetic grounds. Repeated administration of oxymorphazone daily for 3 days resulted in significant tolerance."
Here's where I found this: http://www.ncbi.nlm.nih.gov/pubmed/6204757
It chemically joins to the receptor.... a usual opiate will just stay in the receptor..and so it can be displaced by and agonist, antagonist, or mixed agonist-antagonist/partial agonist..makes it sound very dangerous to me...but I know very little.
As far as where they're keeping this stuff...I haven't figured that out yet..I just heard of it 10 min. ago.
token
"Acutely, oxymorphazone (ED50, 0.6 mg/kg, sc) was approximately half as potent as oxymorphone (ED50, 0.3 mg/kg, sc) in the tail-flick assay. Administered at their ED50 doses, both compounds had the same durations of action. As the doses of drug were increased, however, the time course of oxymorphazone's analgesia became far more prolonged than that of oxymorphone. Following the administration of oxymorphazone (100 mg/kg), over 50% of the mice remained analgesic for greater than 24 hr, as opposed to none of the mice given oxymorphone (100 mg/kg). Oxymorphazone was far more potent intraventricularly (icv) than systemically. Fifty percent of the mice remained analgesic for greater than 20 hr following the injection of 40 micrograms/mouse (icv), whereas no mice remained analgesic after 20 hr following doses of oxymorphone as high as 50 micrograms/mouse (icv). These long-lasting analgesic actions of oxymorphazone could not be easily explained on pharmacokinetic grounds. Repeated administration of oxymorphazone daily for 3 days resulted in significant tolerance."
Here's where I found this: http://www.ncbi.nlm.nih.gov/pubmed/6204757
It chemically joins to the receptor.... a usual opiate will just stay in the receptor..and so it can be displaced by and agonist, antagonist, or mixed agonist-antagonist/partial agonist..makes it sound very dangerous to me...but I know very little.
As far as where they're keeping this stuff...I haven't figured that out yet..I just heard of it 10 min. ago.
token
Last edited:
Rob27shred
Bluelighter
It's probably just an experimental compound. I could only find the same info you guys already did. There is literally millions of different versions of opiates that have been created by experimenting with the known compounds. Just look up analogs of fentanyl, they have created some versions of fentanyl so strong the only use it to tranquilize huge animals such as elephants. From the sounds of it I wouldn't want mess it, anything that has that high of an affinity for opie receptors probably would have a beast of a WD. Or maybe even something worse cause they suggest that it binds to the receptors in way that is unique to most opies.
trunkofmycar
Bluelighter
Where did you hear of this drug existing in the first place, OP?
I don't know about where they heard about it, but I heard about it a few weeks/couple months ago from captain.heroin on here talking about what would be their ideal DoC (drug of choice; ironic that the abbreviation spells doc, no? 
)
)