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Opioids Oxycontin hangover and some other questions

darthrhonin

darthrhonin

Bluelighter
Joined
Feb 12, 2012
Messages
100
Location
Bergamo, Italy
Hi folks
i just got a 28x40mg oxycontin pills box, and it was my first opiates experience (apart from eating some opium in a hippie village)
soooo i was really excited yesterday evening. I divided a pill in 4 equal parts (so 10mg each) and started dosing.
I drank 1/4 crushed with a 0,5 beer, and i chewed the other 3 parts in about 30 mins.
Then, when the oxy was kicking in, i went out smoking a joint of high quality weed.
Felt great, like paradise, but now i have a very annoying hangover, including headaches, nausea (without puking), dizziness and weakness
So i have some questions to do...
first of all, was 40mg too much for a first opiate experience? Could be that the oxy is still active in my body (i take 20mg daily fluoxetine so my liver enzimes are quite slowed)?
And if i dose let's say 20mg now, there's a risk of developing addiction though it's the 2nd time i dose?
While i wait your answers, btw, i'm going to smoke a joint..surely help with the headaches xD

edit: oh i almost forgot..it's the 2nd day without benzos, i've been on xanax, valium and lexotan at medium dosage (1 xanax 1 valium 1 lexo daily)..could this be involved?
 
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Personally, I've never experienced a hangover from opiates. Did you drink more than just the half a beer you mentioned? I wouldn't say that 40mg was too much, just continue to dose slowly so you can tell how much you need/want. I recommend snorting (insufflating) 1 or 2 parts when you have that many as well. A lot of people can't stand the APAP (Tylenol) when snorting percs, but its not all that bad. As far as your addiction question goes, you're not at risk of developing one at this stage. In general it takes at least a couple weeks of regular use to develop a physical dependence (in my experience at least). I am unfamiliar with fluoxetine, so I'm uncertain if it could be have an effect or an interaction.
 
Did a check on another websites drug interactions checker for your oxycodone and fluoxetine. Here are the results:

MONITOR: Coadministration of oxycodone with serotonin reuptake inhibitors has been associated with development of the serotonin syndrome. The mechanism of interaction is unknown. Unlike other analgesics such as phenylpiperidine opioids (e.g., meperidine) and tramadol, oxycodone is not known to possess serotonergic activity and has not previously been associated with the serotonin syndrome. The report describes a bone marrow transplant patient who developed severe tremors and visual hallucinations after he dramatically increased his dosage of oxycodone while on a stable dosage of sertraline and cyclosporine. Discontinuation of cyclosporine did not completely resolve his hallucinations and had no effect on the tremors after 72 hours, which led to consideration of a possible sertraline-oxycodone interaction. The patient's symptoms resolved after sertraline was withheld and cyproheptadine (a central serotonin antagonist) administered. Serotonin syndrome is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: Until more data are available, caution is advised if oxycodone is prescribed in combination with serotonin reuptake inhibitors, particularly in complicated patients such as transplant patients who are also receiving cyclosporine. Patients should be monitored for symptoms of the serotonin syndrome during treatment. Particular caution is advised when increasing the dosages of these agents. If serotonin syndrome develops or is suspected during the course of therapy, all serotonergic agents should be discontinued immediately and supportive care rendered as necessary. Moderately ill patients may also benefit from the administration of a serotonin antagonist (e.g., cyproheptadine, chlorpromazine). Severe cases should be managed under consultation with a toxicologist and may require sedation, neuromuscular paralysis, intubation, and mechanical ventilation in addition to the other measures. Patients should also be advised of potentially additive central nervous system effects from these agents and to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them.

Edit: After a touch of googling I haven't found anyone else reporting prozac (fluoxetine) and oxycodone to cause anything akin to what you've mentioned.
 
darthrhonin said:
Hi folks
i just got a 28x40mg oxycontin pills box, and it was my first opiates experience (apart from eating some opium in a hippie village)
soooo i was really excited yesterday evening. I divided a pill in 4 equal parts (so 10mg each) and started dosing.
I drank 1/4 crushed with a 0,5 beer, and i chewed the other 3 parts in about 30 mins.
Then, when the oxy was kicking in, i went out smoking a joint of high quality weed.
Felt great, like paradise, but now i have a very annoying hangover, including headaches, nausea (without puking), dizziness and weakness
So i have some questions to do...
first of all, was 40mg too much for a first opiate experience? Could be that the oxy is still active in my body (i take 20mg daily fluoxetine so my liver enzimes are quite slowed)?
And if i dose let's say 20mg now, there's a risk of developing addiction though it's the 2nd time i dose?
While i wait your answers, btw, i'm going to smoke a joint..surely help with the headaches xD

edit: oh i almost forgot..it's the 2nd day without benzos, i've been on xanax, valium and lexotan at medium dosage (1 xanax 1 valium 1 lexo daily)..could this be involved?
Click to expand...

Ok, so it was....
1. Your first time using oxycontin.
2. You had some alcohol.
3. You smoked weed.
4. You have been off benzos for two days.

All these points together is why you are feeling the way you are.

(opiates can cause nausea on their own, especially being your first time - that being said, I think the combination of being off the benzos for 2 days that would start the "jitters" and then mixing the other substances [including the weed] just pushed it too far).

I wouldn't smoke too much because even though you might not think it, being in a "semi benzo withdrawal" state, smoking can increase anxiety and dizziness quite a bit for some people.

I think if you just tried the oxy on its own (being your first time and all) it would have been a wiser decision (keep this in mind for the future), I don't think you will develop an addiction after the second dose, BUT you have 28 of those pills, and that is a big "red flag", be careful.

There is a positive side although, and that is you didn't mix the benzos with the opiates.

But for next time, if you plan ahead and know how you will feel if you don't, then this is a learning curve for you.

But again, those 28 pills is worrying for me.
 
So i will be careful with smoking
Yes 28 pills are definitely enough to cause severe addiction i think :P
But i plan to use them rarely also due to the tolerance and to the other drugs i might take (i like to switch from one to other)
regarding the serotonin syndrome, i never tought that opiates like oxy could have effects on serotonin release that's weird
Edit: After a touch of googling I haven't found anyone else reporting prozac (fluoxetine) and oxycodone to cause anything akin to what you've mentioned.
Click to expand...
fluoxetine is an inhibitor of the enzimes which also metabolize the oxy ;)

EDIT: oxy can also cause itching?
 
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Drink lots and lots of water. Opiates make you severely dehydrated and it's a big reason why people feel so shitty after a using session (provided the feelings aren't withdrawal related, just opiate hangover)
 
probably the first 2-4 times i used oxy i had hangover symptoms like you mentioned, iv heard a lot of people say the same thing, although not everyone experiences this. in general i would avoid alcohol (and benzos) while on strong opiates like oxy as the risk of CNS depression is considerably higher when mixing (although damn nice=D)
also welcome to bluelight nice to see some more Italians about.
 
Yeah a big-ish dose of opiates for an opiate naiive person can cause a hangover, but most likely ur feelings are from benzo w/d. But the fact that u took a big dose of oxy the day before could also be makeing the benzo w/d worse.m..
 
I agree with everything, especially shreddedlettuce. But yeah man 48 pills is enough to consume you... forever... tread lightly.
 
hey it's 28 pills not 48 unluckily :P
by the way thanks to all for the replies..i found 40 mg ingested in 2 sessions (like 15 mins of distance) to be the best for me...i also noticed a softer hangover now that the benzo withdrawal is going slowly away...the only damn annoying thing is the terrible itching it gives to me.
I'm quite used to it due to my celiac disorder but it's really annoying v_v
Uh and...it's normal that i don't feel any sort of addiction even now? After 5 days of benzo using i was experiencing some kind of addiction while on oxy not...or not yet XD
 
darthrhonin said:
hey it's 28 pills not 48 unluckily :P
by the way thanks to all for the replies..i found 40 mg ingested in 2 sessions (like 15 mins of distance) to be the best for me...i also noticed a softer hangover now that the benzo withdrawal is going slowly away...the only damn annoying thing is the terrible itching it gives to me.
I'm quite used to it due to my celiac disorder but it's really annoying v_v
Uh and...it's normal that i don't feel any sort of addiction even now? After 5 days of benzo using i was experiencing some kind of addiction while on oxy not...or not yet XD
Click to expand...

How many days in a row have you been using the oxy? Have you ever had an psychical dependence to opiates in the past?
 
now it's the 4th day in a row, and no, never had any dependence to opiates...
...just crushed and swallowed 80mg by the way cause i think the 40mg ER pill of 12.00 is gone :P
 
It can take a long time in the beginning for someone to pick up their first ever opiate habit.. I've seen it take weeks, even months of everyday use for it to happen. Keep in mind I said the first time... once you do become dependent, it happens faster and faster every time thereafter. It can definitely happen earlier even in the beginning, but usually not in only 4 days.
 
good to hear that, so i can do some constant use without worrying too much and then discontinue to avoid the risk
sounds wonderful, totally different from benzos!
 
darthrhonin said:
good to hear that, so i can do some constant use without worrying too much and then discontinue to avoid the risk
sounds wonderful, totally different from benzos!
Click to expand...

Woha, wait a minute cowboy.. haha. I didn't mean that as have a big free for all. Benzos work the same way... sometimes it takes even longer to develop a benzo habit than an opiate one. It's very possible that if you use for another couple days in a row you could wake up with withdrawal symptoms.. why risk it? Don't use anymore than 3 days in a row if you can help it and you'll avoid it.
 
ok message received ahahahah :D I said that 'cause for me benzo addiction came up really fast (like 2-3 days of acute dosing), so i'll be very careful, don't want to waste other months of my life fixing another addiction :P
 
40mg is a bit much for a first time, you'd probably have done fine with 20mg without feeling like shit the next day. Although I've been using opiates for quite some time and I still get horrible nauseous hangovers so that's not necessarily something you'll ever get rid of unfortunately.
And no, you will not get addicted after the second time, but as Mr. Scagnattie said, don't use for more than 3 days in a row and just be very careful not to start justifying your using...it's a dangerous road to go down.
 
quite like that, not a severe addiction but terribles headaches, muscular rigidity and lack of sleep
maybe was also the alcohol, i drink much less now than before, so could be involved (srry typos, it's kicking in)

edit: acute dosing meaning 5-6 0.5 xanax
 
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