No.
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"If we could sniff or swallow something that would, for five or six hours each day, abolish our solitude as individuals...and make life in all its aspects seem not only worth living, but divinely beautiful and significant...earth would become paradise."
Nope! There are no harmfull interactions in combining an SSRI and an opioid ....
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"I am not one of those weak-spirited, sappy Americans who want to be liked by all the people around them. I don't care if people hate my guts; I assume most of them do. The important question is: 'What are they in a position to do about it?'" (William S. Burroughs)