Oxycontin - 12 hours of pain relief?

[4DQSAR]

OxyContin was submitted and justifiably approved by the agency as a 12-hour dosage form - PMC

pmc.ncbi.nlm.nih.gov

I am someone for whom phenolic (morphine, hydromorphone, oxymorphone) opioids have no effect whatsoever. This is a known issue with ceertain people rapidly gluconating such medicines with the result that they are excreted from the body before they can act.

So although I am prescribed 80mg of generic oxycodone SR, what my doctor quietly did was to split my medication into two 30mg doses and a 20mg dose. This works fine but it's interesting that while the problem is acknowlwdged, she said it was (and I quote) 'illegal for doctors to prescribe a dose interval other than 12 hours'. Funny thing is, the specialist at the pain clinic was FINE with me taking the medication TID. His attitude was simply 'if it works - fine'. So it appears that specialists are QUITE aware of the issue and yet although recognized, it remains ignored.

It does make things a little difficult having a 9:9:6 dose interval but I manage.

Has anyone else struggled with this problem? I can only imagine that those for whom oxycodone SR DOESN'T last 12 hours are actually more likely to go on to become 'addicted' if you term 'the biological urge not to be in pain' as addiction.

I might add that 40mg at once is far too much. Others speak of euphoria. Dysphoria is what I get so after many years, I'm quite sure I am physically dependant but at the same time, I have 3 boxes of 30s and 30 boxes of 10s in my drawer with no thought of taking more. I can manage anxiety without oxycodone, thanks. I'm informed that dysphoria and anxiety are quite rare side-effects but it does ensure I'm not even tempted to take more.

 

[WellTram]

Oxy should last 12 hours in pill that they made but oxy has short half-life, it never helped me for more than 8 hours.

 

[4DQSAR]

Read the damned paper - it notes the mean time oxycodone SR relieved pain for was 9.6 hours.

In the UK the livery of the generic oxycodone SR tablets even bear the workds 'relieves pain for upto 12 hours' - so it seems pretty apparent to me that the issue is recognized even by manufacturers.

But a GP can only prescribe according to BNF guidelines, a specialist has more leeway. I mentioned how I split the dose into 3 to my consultant and he just said 'if it works - fine'.

 

[Coffeeshroom]

I was scripted 40mg Oxy ER every 12hr and it never made the full mile, so I got scripted 10mg IR on the side to bridge gaps.

And guess stuff like methadone or fentanyl patches etc aren't an option, strictly speaking if this is for pure pain management.

 

[4DQSAR]

I was scripted 40mg Oxy ER every 12hr and it never made the full mile, so I got scripted 10mg IR on the side to bridge gaps.

And guess stuff like methadone or fentanyl patches etc aren't an option, strictly speaking if this is for pure pain management.

For me 30mg is clearly ENOUGHT i.e. any more taken at once is simply too much. But like you, it simply doesn't last. I got 10mg SRs and consume the mixture in the manner described.

I'm glad to hear that doctors are beginning to accept this issue.

Did you know the OFFICIAL Perdue response to Oxycontin failing to last 12 hours? Increase the does. I tried that and I would feel spaced out for a few hours and then it STILL didn't kast for 12 hours. BUT it's important to note that Perdue told it's marketing peoplle to PUSH the fact that their product acts ffor 12 hours. Never accept that the stuff just doesn't have the legs.

 

[lovemissile66]

OxyContin was submitted and justifiably approved by the agency as a 12-hour dosage form - PMC

pmc.ncbi.nlm.nih.gov

I am someone for whom phenolic (morphine, hydromorphone, oxymorphone) opioids have no effect whatsoever. This is a known issue with ceertain people rapidly gluconating such medicines with the result that they are excreted from the body before they can act.

So although I am prescribed 80mg of generic oxycodone SR, what my doctor quietly did was to split my medication into two 30mg doses and a 20mg dose. This works fine but it's interesting that while the problem is acknowlwdged, she said it was (and I quote) 'illegal for doctors to prescribe a dose interval other than 12 hours'. Funny thing is, the specialist at the pain clinic was FINE with me taking the medication TID. His attitude was simply 'if it works - fine'. So it appears that specialists are QUITE aware of the issue and yet although recognized, it remains ignored.

It does make things a little difficult having a 9:9:6 dose interval but I manage.

Has anyone else struggled with this problem? I can only imagine that those for whom oxycodone SR DOESN'T last 12 hours are actually more likely to go on to become 'addicted' if you term 'the biological urge not to be in pain' as addiction.

I might add that 40mg at once is far too much. Others speak of euphoria. Dysphoria is what I get so after many years, I'm quite sure I am physically dependant but at the same time, I have 3 boxes of 30s and 30 boxes of 10s in my drawer with no thought of taking more. I can manage anxiety without oxycodone, thanks. I'm informed that dysphoria and anxiety are quite rare side-effects but it does ensure I'm not even tempted to take more.

Hello and hope all is well with you. How did you manage to stockpile 30 boxes of oxycodone?! And also, I hope for your security, nobody can access that drawer

 

[4DQSAR]

Hello and hope all is well with you. How did you manage to stockpile 30 boxes of oxycodone?! And also, I hope for your security, nobody can access that drawer

It;'s a large locked steel cabinet. I also live in sheltered housing which means outside of my home is covered by multiple CCTV cameras.

I'm also more ot less housebound so it's unlikely anyone would find my home empty.

 

[WellTram]

But DHC Continus, Morphine Continus front India lasts 12 hours.

 

[4DQSAR]

But DHC Continus, Morphine Continus front India lasts 12 hours.

Again, just because it may act for 12 hours in one individual is no sort of conformation that it will last 12 hours in another.

Morphine has no effect on me whatsoever. So it was never an option.

 

[TheGyattDamnRizzler]

I never get 12 hours from opiates. It is technically still in your system though even if it isn't peak effect. Stimulants are measured the same. My adderall works for 4 - 5 hours, it says one pill is good for 12 hours.

It all comes to how you metabolize it. If you are concerned because need more I would tell your doctor.