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Opioids Oxycodone Tolerance

C

Chim721

Greenlighter
Joined
Oct 4, 2009
Messages
29
Location
Central/North Jersey
I was taking oxy.. 60mg a day and felt great. Messed with opana for 2 weeks. Went back to oxy and I need 150mg to feel even slightly anything. How long to drop my tolerance so that I'd feel great on 15mgs oxy again? That used to do me great months ago!
 
What screwed me was I came across a bunch of Opana and was snorting 60mgs a day in one sitting and it blew oxy out of the water. Than when I went back to oxy it did nothing. =( So I'm taking a break for a while but I wanna know how long.
 
A long, long time. 6 months in jail barely touched my tolerance sadly. A week of use and it was like I never even had a break, and I have a fast metabolism if that effects anything.
 
"Oxymorphone(OPANA) is also produced within the human body where the liver metabolises oxycodone by means of O demethylation catalysed by the CytochroEREme P-450 enzyme family, in particular the II-D-6 and III-A-2 thereof. Approximately 10 per cent of the dose is processed by the endocrine system in this respect; this can vary widely from person to person. The codeine-hydrocodone group and morphinans exhibit the same characteristics."

I dont know to much about oxymorphone(Opana) but this little stub from wikipedia says(or atleast I think it says) that this drug is metabolised exactly the same way as oxycodone therefore its like if you took vicodin and then a few days later took heroin you wouldnt have a tolerance to the heroin because you took vicodin a few days before and not heroin. but with oxymorphone(opana) there is a cross tolerance between Opana and oxycodone. not like say morphine and oxycotton. although morphine and codeine also have a cross tolerance just like opana and oxycotton because codeine gets metabolised into morphine. so its pretty much as if you were taking oxycodone or when you were taking the Opana, basically Opana is just a stronger version of oxycotton so no wonder u built a tolerance, Opana is like two times stronger than oxycodone but their basically the same except for the stronger potency of opana. im not sure if this is true but this would be my guess.

oh and inccase you dont know oxycodone and oxycotton are the same drug, just incase u got confused from that
 
I would just find a different opiate if i could. Say maybe codiene, vicodin, or morphine, etc... theirs alot of diff opiates out there that dont cross each others borders. but if you cant find any other ones besides oxy and opana then just wait a week or two you should be back to 15mg of oxy in atleast 2 weeks to a month. tolerance comes with the addiction tho so u better get used to it
 
Paulination said:
"Oxymorphone(OPANA) is also produced within the human body where the liver metabolises oxycodone by means of O demethylation catalysed by the CytochroEREme P-450 enzyme family, in particular the II-D-6 and III-A-2 thereof. Approximately 10 per cent of the dose is processed by the endocrine system in this respect; this can vary widely from person to person. The codeine-hydrocodone group and morphinans exhibit the same characteristics."

I dont know to much about oxymorphone(Opana) but this little stub from wikipedia says(or atleast I think it says) that this drug is metabolised exactly the same way as oxycodone therefore its like if you took vicodin and then a few days later took heroin you wouldnt have a tolerance to the heroin because you took vicodin a few days before and not heroin. but with oxymorphone(opana) there is a cross tolerance between Opana and oxycodone. not like say morphine and oxycotton. although morphine and codeine also have a cross tolerance just like opana and oxycotton because codeine gets metabolised into morphine. so its pretty much as if you were taking oxycodone or when you were taking the Opana, basically Opana is just a stronger version of oxycotton so no wonder u built a tolerance, Opana is like two times stronger than oxycodone but their basically the same except for the stronger potency of opana. im not sure if this is true but this would be my guess.

oh and inccase you dont know oxycodone and oxycotton are the same drug, just incase u got confused from that
Click to expand...

its Oxycontin,not Oxycotton,and all opiates/opioids have a cross tolerance,if your tolerant/addicted to one,you're tolerant and addicted to them all.
 
Lol but im not to sure about this with opana all i did was take a quick read of opana in wikipedia and im watching fear and loathing right now. and besides i take 24mg suboxone a day so if u guys need any advice on that i could definatley help u.

heres my thread on some tips with suboxone if any of you use it recreationally. personally ive takin heroin,vicodin,darvocet,oxycotton,morphine,codiene...and alot of others but i still havent found anything and strong and long lasting as suboxone. my first time was when i took 3 8mg's a little to much i was on the line of getting a tummy ache but WHAM i was feeling awsome for two days straight and it was a better high than any other opiate i had. im a minority in this case tho. lol if you guys are addicted to opiates and want to stop or its to pricey i would find a suboxone doctor.

http://www.bluelight.ru/vb/showthread.php?t=506341
 
OntarioGuy said:
its Oxycontin,not Oxycotton,and all opiates/opioids have a cross tolerance,if your tolerant/addicted to one,you're tolerant and addicted to them all.
Click to expand...

well hell that may be true. but if that was why would doctors prescribe different opiates each week to people who have major pain and not all doctors do this. but their have been studys show nthat say that most pain killers do not have a cross tolerance. have u ever tried taking heroin for 2 weeks and then taking 5 10/375 vicodin? oxycotton is a cooler way to say it :D
 
^ you wrote Oxycotton again lol...its Oxycontin,as in OXYcodone CONTINuous release,just like MS Contin or here in canada Hydromorph Contin.

to the op:I'm sure you're going to experience some discomfort after the use you described.I say get out now,Im 20 years old and have been on opiates for 5 years.Methadone at 16 years old.My lower intestine exploded a couple years ago,I've been on them all and its pure hell when I dont have my meds.

Edit:you squeezed in a new post you sneaky bugger :D
I find they all have a cross tolerance though....I personally need alot of any opiate to maintain....Ideally a fix for me is 75-100 milligrams of IV morphine,120-160 milligrams of Oxy IV,or 12-16 mg's of IV dilaudid....I find thes are all in the same potency range for me.if they didn't have a cross tolerance,the doses would vary much more wildly between the 3.like I said the doses I listed feel equally potent to me.
 
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If you want your tolerance to lower quickly don't take the suboxone, just suffer through the withdrawals, or load up on benzodiazapines and sleep it out.
 
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