• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • BDD Moderators: Keif’ Richards | negrogesic

Opioids Oxycodone & Lexapro (SSRI's)

sadmachine

Bluelighter
Joined
Apr 14, 2022
Messages
63
So I started Escitalopram (lexapro) about a month ago and it's helping a lot. A few days in I started smoking weed again which helped immensely with the initial side effects. I've been a dabbler/chipper with oxy for the past 2-3 years and I picked up a sheet recently and noticed that the buzz only lasted about half an hour and then was completely gone. I even dosed above my usual highest dose (60-80mg) and barely got anything. Despite this I am craving opioids like I never have before. I skipped a dose of lexapro to see if I could get a good nod going and it just ended up keeping me awake all night but no typical buzz.

Has anyone used opioids while on an SSRI? Did you experience the same thing? Any tricks?
 
Never with a sssri but with effexor a snri yes and the codeine i was taking worked fine. I took various opiates with tricyclics no problem to
 
Interesting. I read that Lexapro is meant to be a weaker/negligible inhibitor of the goodie enzyme for oxycodone but seems to be messing my shit up. I'm gonna take a few days off the lexapro to indulge I think. I've had a ton of issues with Oxy not working properly before, and when I try to boost it with GFJ I get migraines. I think maybe i'm just not a good metabolizer of it, shame it's all I can get.
 
Interesting. I read that Lexapro is meant to be a weaker/negligible inhibitor of the goodie enzyme for oxycodone but seems to be messing my shit up. I'm gonna take a few days off the lexapro to indulge I think. I've had a ton of issues with Oxy not working properly before, and when I try to boost it with GFJ I get migraines. I think maybe i'm just not a good metabolizer of it, shame it's all I can get.
You better be careful Lexapro is know to cause pretty severe withdrawal from missing as little as a single dose.
 
Top