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Opioids Oxycodone & APAP Question..

T

TheKidThesis

Greenlighter
Joined
Oct 12, 2011
Messages
9
Location
Pennsylvania
Hello Everyone, I was wondering what exactly is too much APAP? there are people who take thousands of MG's of this drug a day yet I heard it is awful for the liver.. for instance I am on Oxycodone 7.5/325 & I need at least 10 a day to be right pain wise no euphoria.. I know ya'll aint doctors but give me a little info on APAP ya'll.
 
4000mg a day is the limit but you shouldn't use that much regularly; for regular use I wouldn't recommend over 2000mg a day. If I were you I would do a cold water extraction, that much apap is horrid for your liver.
 
TheKidThesis said:
Hello Everyone, I was wondering what exactly is too much APAP? there are people who take thousands of MG's of this drug a day yet I heard it is awful for the liver.. for instance I am on Oxycodone 7.5/325 & I need at least 10 a day to be right pain wise no euphoria.. I know ya'll aint doctors but give me a little info on APAP ya'll.
Click to expand...

Why not ask your doctor for oxycodone 15mg or OC80?
 
Although I've just begun pain management last week, I was under the impression you couldn't "ask" for a certain medication. So far, I've had no say in what's been prescribed for me other than answering the questions, "can you tolerate the substance" and "do you have any side effects?"

I'm on Percocet 5/325 even though they're not strong enough and Tramadol 50mg even though they do next to nothing. I feel like if I were to ask my Dr. for 10mg percs or better yet, the 15mg without APAP he'd kick me out.

I even asked him today if I could take two percs at a time (I've been taking three >_>) and he said absolutely not, even though I told him that one does next to nothing.

I guess everyone's doctor is different, but mine is like a Nazi.
 
There are 5mg oxy IR, which is essentially the same thing that you are on, but with no tylenol. I think that would be the best thing to look into if you are concerned about liver damage.
 
Ksa said:
He would have to take more than 5mg oxy if you remove the APAP. The combination of APAP and oxy relief pain much more efficiently than oxy alone or they wouldn't put it.
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That's debatable. If the tylenol helps with the pain, it only does a little, I wouldn't say it is "much more efficient than oxy alone." They have been putting it in forever, and are now lowering the maximum amount of tylenol per pain killer/apap combo to be 325mgs. Some doctors may increase the opiate dosage, but I'm not sure by how much.

Here is an article about APAP, and the reasons behind lowering the maximum dosage in pain killer preparations.
 
...instead of the apap, he could add in 200-400mgs naproxen sodium for improved pain relief. i say ask for the 5mg oxy with no apap.

if you are too afraid to ask your doctor to switch you or he won't give you pure oxy, then i recommend performing a CWE
 
Last edited:
laCster said:
...instead of the apap, he could add in 200-400mgs naproxen sodium for improved pain relief. i say ask for the 5mg oxy with no apap.

if you are too afraid to ask your doctor to switch you or he won't give you pure oxy, then i recommend performing a CWE
Click to expand...

What exactly is a CWE?
 
Tommyboy said:
That's debatable. If the tylenol helps with the pain, it only does a little, I wouldn't say it is "much more efficient than oxy alone." They have been putting it in forever, and are now lowering the maximum amount of tylenol per pain killer/apap combo to be 325mgs. Some doctors may increase the opiate dosage, but I'm not sure by how much.

Here is an article about APAP, and the reasons behind lowering the maximum dosage in pain killer preparations.
Click to expand...

COX-2 inhibition is highly effective for back pain and arthritis.
 
... if he is taking 10 a day they must not be lasting long...

BTW, tylenol is literally useless if your taking high doses of percocet or any other APAP/opioid. This is because,IIRC, APAP has a ceiling effect, much like aspirin, where pain relief per mg begins to slowly decrease until it presumably gets to the point where increasing dose will not provide anymore analgesia. Of course, people taking "prescribed" doses of pills(such as 1-2 percocet every 4-6 hours) may be slightly effected, but not people with tolerances.

@SaoisinEngaged: you are the one paying your doctor. If he is insisting you can't take more than 1 percocet at a time, when an ER has wrote me out 20mg at a time, you need to straighten him out, and if he still won't budge, tell him you will find a doctor who knows they're ass for a hole in the ground. Remember, you are paying his stupid-ass.
 
^^ Amen.

You have nothing to lose from asking. If he says no, switch doctors. Last time I checked, there's not exactly a shortage of pain clinics so the odds are in your favor. There happens to be quite a lot where I live so it's pretty competitive.. which in turn works out pretty nicely ;)
 
Ksa said:
COX-2 inhibition is highly effective for back pain and arthritis.
Click to expand...

See the post I quoted below. I don't know what arthritis has to do with our current conversation though. I said that some doctors may increase the opiate dose if they switch to a pain med that doesn't have apap in it, but I really don't think that they will increase the opiate dose much, if any.

Saying that apap is highly effective for back pain and arthritis doesn't really touch on any of the points that are being made. How much more of an opiate dose do you think a person would need to take if they switched to meds with no apap, if they were on 3 10/325 oxy/apap daily for example?

I think that most doctors would just tell the patient to have some tylenol on hand to take if the opiate alone was not providing adequate pain relief.

lorne667 said:
... if he is taking 10 a day they must not be lasting long...

BTW, tylenol is literally useless if your taking high doses of percocet or any other APAP/opioid. This is because,IIRC, APAP has a ceiling effect, much like aspirin, where pain relief per mg begins to slowly decrease until it presumably gets to the point where increasing dose will not provide anymore analgesia. Of course, people taking "prescribed" doses of pills(such as 1-2 percocet every 4-6 hours) may be slightly effected, but not people with tolerances.

@SaoisinEngaged: you are the one paying your doctor. If he is insisting you can't take more than 1 percocet at a time, when an ER has wrote me out 20mg at a time, you need to straighten him out, and if he still won't budge, tell him you will find a doctor who knows they're ass for a hole in the ground. Remember, you are paying his stupid-ass.
Click to expand...
 
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