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Opioids Oxy + Hydromorphone

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reflekt

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Feb 22, 2011
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So I took 45mg Oxycodone and I'm feeling it... but nothing crazy. I'm usually a hydromorphone user. And I'll have morphine every once in a while to treat myself because I love it tehe.

Anyway. If I insufflated some hydro would the opiates potentiate each other well? Would it create a synergistic effect? I'm not sure if it would because they're both stimulating opiates.

I do also have morphine on hand but it's currently sitting in liquid breaking the time release (has been 5.5 hours so far, so not enough to fully beat the time release mechanism).

I just feel like I wasted the oxy as I should have more tomorrow lol.

P.S. Irrelevant to the main point of my post... But... Are benzos best taken before or after opiates for potentiation/added sedation?
 
It really depends on the benzo that you are thinking about taking. If its a quick acting short half life benzo it will definitely help the nod but it will hange the flavor. If I were you I'd add the hydro as long as its a reasonable dose, it won't be over stimulating. At least not in my opinion. I wouldn't want to waste the oxy with a half assed high, but that's not exactly harm reduction.
 
Yeah the opiates would go well together, just because you'd be hitting different parts of the opioid receptors in your brain giving you both feelings at once, which can be very euphoric. Just make sure what you're taking is within your tolerance range.

As for the benzos i would take them before so they're kicking in when the opiate does, but be careful mixing opioids and benzos, and especially 2 different opioids on top of a benzo. Start low with the dose of the benzo. A large portion of overdose deaths is due to opioids/benzos together. Just be careful, know your limits. Remember you can always take more never less.
 
What benzo are you consider taking? It would help us a lot, but it may be to far past initial consumption of the opioids do gave the maximum desired effect. It may help with the insomnia and residual stimulation after your combo starts to wear off.
 
Benzodiazepines should not be combined with opioids due to the increased CNS / respiratory depression. Please man, reconsider this. It's really not worth it, if you aren't sedated enough honestly IMO the most HR thing you could do would be carefully dose more opioids to desired effect. It's so unsafe to mix benzodiazepines with opioids man, the risk of OD is absolutely exponential.

As for the synergy effect, yes, different opioids synergize nicely with eachother, but this also raises risk of overdose, although not nearly to the extent of adding in benzodiazepines. Adding in benzodiazepines is just adding bullets to the chamber on the gun you're playing roulette with.

Calculate the half-lives and bioavailabilities of the medications in question and that way you can tell how long each drug will be in your system, factoring in of course, in milligrams the estimated maximum level of the drug in your blood.
 
^^ agreed, if you're already walking into unknown territory by mixing two opioids, don't add a benzo. The percentages of opioid/benzo overdose as opposed to either on thier own is staggering to say the least.
 
I ended up getting more oxy anyway so I just took more and have been feeling great since. Now borderline on the nod lol.

But the benzo I was refering to was Valium. I always have vals on hand. But thank you all for the responses. And the suggestion of a shorter lasting, quick hitting benzo is one I will keep in mind for next time as I will be getting some xanax bars in a couple days.

And I appreciate the concern, tricomb. I always do and definitely will always keep an eye on the substances that i take ad their amounts to avoid any danger.
 
Please stay on topic. I've gone through this thread and removed all off-topic posts. If you don't have anything to contribute to the OP's question, please don't post here. Issues with moderators should be taken up via the appropriate channels. Hijacking a thread is not an appropriate channel. Social discussion should be done in the appropriate OD social thread. Continued disruption of threads will result in infractions.

In regards to the OP's question, I'm going to echo what others have said, mixing two opiates together is going to give you a very powerful high - so I don't recommend adding a benzo on top of that mix. Also, since you're combining opiates, don't take your normal dose of hydromorphone. Reduce it by 25%-50%.
 
Thank you very much, NeighborhoodThreat :). You're always a great help! Case solved!
 
I think the basic questions in this thread have been solved.

Mixing benzodiazepine's and opiates is dangerous as it can lead to resperitory depression

Combining two opiates/opioids will cause a more powerful effect, therefore, if you are going to do this (not recomended), take only a fraction of the dose you would normally take of the second opiate.


I'm going to close this as I feel the questions have been answered. @OP, PM me if you have any questions about my decision.
 
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