Oxy has more euphoria on a stim comedown

[falsifiedhypothesi]

For the brief time I had access to both Oxycodone and adderall I noticed a wierd dichotomy between effects.

I would take a dose of 25mg xr adderall chewed or crushed then obviously crash maybe 5 hours later. I would feel like hell, sweating, dehydration, dysphoria, the regular adderall crash. After a few instances of the horrible crash I decided to supplement the torment with oxy.

When the comedown hit I preped my usual dose of oxy, took the dose, then waited. I was expecting the normal oxy rush (I call it a rush, some may not) and I got it, but with the addition of much stronger euphoric waves, along with great repose. It was more than mere relief from the state I was previously in. Has anyone else experienced anything like this?

 

[maddiemax]

unfortunately i've never had access to both addys and oxy at the same time, but if you think about it does make sense that you would feel more euphoric. In general, the euphoria comes from the release of dopamine. Adderall releases muuuuch more dopamine than oxycodone however oxycodone releases a lot of dopamine as well.... your 25mg XR adderall caused a relatively massive flood of dopamine to your brain... within 5 hours you started to feel the effects wear off (but this doesn't mean that your dopamine levels are low) in fact, at 5 hours after XR, dopamine levels are still elevated they are just significantly less than what they were about 3 hours prior which is why you felt like shit. then, after taking the oxycodone, your brain's dopamine levels increased on top of what adderall caused. compared to the times you took it without adderall it didn't feel as euphoric because this time u had more dopamine to start with.

 

[P.o.T.u.S]

of course u will feel more euphoria if u go from feeling like shit to bein high on opies rather than feeling normal and then getting high.

 

[F1n1shed]

I've noticed this too. Oxy on a coke comedown and it seemed to give me more euphoria than normal. Maybe because i felt so relieved that the damn coke comedown was gone which caused more oxy 'euphoria' ?

 

[falsifiedhypothesi]

I thought that it might be the relief as well but when I tried the same thing with an alcohol hangover it just blunted the opiate effects and had me feeling better.