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  • BDD Moderators: Keif’ Richards

Overcoming the slow release mechanism of pills by dissolving them beforehand

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ampakine

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Apr 23, 2011
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I placed 2 DHC continus pills in a glass of water to observe how quickly they dissolve. Its been 2 hours and they are only partially dissolved. Quick release pills of the same size would be fully dissolved in no more than 30 minutes. Is this prolonged dissolution the whole slow release mechanism or is it only part of it? For example are there compounds in there that cause the drug to be absorbed at a slower rate? I'm guessing not because that would just lower the bioavailability seeing unabsorbed compounds get excreted in the urine. I read this wiki page:
https://secure.wikimedia.org/wikipedia/en/wiki/Time_release_technology
and see now there are a variety of different time release mechanisms they use these days but I can't see any reason why dissolving beforehand wouldn't overcome all of the ones listed on that page.

Heres the excipients for DHC continus:

- Lactose (anhydrous)
- Hydroxyethylcellulose
- Cetostearyl Alcohol
- Magnesium Stearate
- Purified Talc
- Purified Water

I know lactose, magnesium stearate, talc are used in instant release pills so that just leaves hydroxyethylcellulose and cetostearyl alcohol.
https://secure.wikimedia.org/wikipedia/en/wiki/Hydroxyethyl_cellulose
https://secure.wikimedia.org/wikipedia/en/wiki/Cetostearyl_alcohol
So hydroxyethyl cellulose is a gelling/thickening agent and cetostearyl alcohol is an emulsion stabiliser and foam boosting surfactant. I'm gonna have to do a bit of research before I can conclude whether this time release mechanism is rendered useless by predissolution or not.
 
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crush. or cut up if they don't crush. then put in lime juice (overnight).

this is for OPs and the XR xanax. don't know about DHC, but can only imagine.
 
hydroazuanacaine said:
crush. or cut up if they don't crush. then put in lime juice (overnight).
Click to expand...

Yeah thats probably the best approach since some time release mechanisms only release the compound in the presence of acid. I'm fairly sure DHC continus have a different mechanism though. Its been about 6 hours now and I see the pills have turned into foam. Thats the mechanism, the pills gradually turn into foam gradually allowing water into the pill matrix and dissolving the DHC. Crushing the pills into powder before dissolving would vastly speed this process up. In fact I'd say that applies to all time release mechanisms, the more you powderise them the easier it will be for the water to reach the DHC and dissolve it.

EDIT: If you're dealing with codeine and other opioids potentiated by grapefruit juice you might be better off using grapefruit juice instead of lime juice to acidify the water. Not sure how acidic it is though.
 
maybe the juices i've used are acidic or something, because my fav method never fails me ;P [smash pill to powder, dissolve/mix into juice, keep it moving and pound it :) ]
/if you're doing the 'stomach digestion' test on pills, there's a better way than just water. i want to say vinegar:water mix, to better approximate the stomach, but it's been a while since i've played w/ that. o and i'd leave the setup on the fridge or washer, both for subtle movement and a lil temperature boost
 
I found a pill pulveriser I bought a few months ago and forgot about so I tested it out on a fairly solid pill that is a pain in the ass to crush with a mortar and pestle and was surprised at how well this thing works. Turned the pill into dust in a matter of seconds and the best part is I didn't lose any of the pill due to chips flying like I usually do when crushing with a mortar and pestle. Just thought I'd share that in case any of you haven't come across pill pulverisers. This is the one I have:
PillPulverizer-RS105.jpg
 
^^^^^^

What the heck is that & where did you buy it?

Also, ive been using carbonated seltzer water for about 6 months now. Ive tried it on all OP's, Morphine SR, Dihydrocodeine pills. I pour about 4 ounces in an empty water bottle, crush the pill finely or as much as I can, then pour it in the bottle, put the cap on & leave over night.

The OP's & Morphine SR both dissolved easily & the water looked clear the next day. I left the dihydrocodeine in for 3 days & it still didnt dissolve it like the other pills.

I drank the OP's & Morphine, of course different days & the drug hit me fast & hard so imo, all the drug was released.

Even tho the dihydrocodeine didnt dissolve like the others, it still hit me pretty hard after I drank it & was definitely stronger than popping the pill or even crushing & swallowing.

Bottom line is this method works great & ime, you get most of the opiate from within the pill.
 
ampakine said:
I found a pill pulveriser I bought a few months ago and forgot about so I tested it out on a fairly solid pill that is a pain in the ass to crush with a mortar and pestle and was surprised at how well this thing works. Turned the pill into dust in a matter of seconds and the best part is I didn't lose any of the pill due to chips flying like I usually do when crushing with a mortar and pestle. Just thought I'd share that in case any of you haven't come across pill pulverisers. This is the one I have:
PillPulverizer-RS105.jpg
Click to expand...

hhhhhrrrrrmmmmmmmmmm, my buddy got the same.exact.thing a few months ago, too. totally bad-ass!!!! generic things like that are common-enough, but that one is big and beastin, love it!
 
TheLostBoys said:
^^^^^^

What the heck is that & where did you buy it?
Click to expand...
Its a pill crusher and I got it in the pharmacy. How it works is you put the pill in the container then you screw the lid on and as you screw the lid on it crushes the pill. I tried putting a handful of pills into it for a CWE once but it didn't powderise them very well, it only works well when you crush 1 or 2 pills at a time.
 
wolverhamptonian said:
Does any one know were to find the C W E method simplifyed version?
Click to expand...

IMO, you are better off doing a popper CWE. Quick routs can be dangerous and less effective. For the simplest, safest rout...
1. Crush pills
2. dissolve in water
3. strain through a shirt
4. strain through a coffee filter
4. repeat step 4
5. drink the mixture
6. try your very best not to vomit
7. enjoy

I usually evaporate the mixture down to about 5ml so I can plug it. I can't keep it down otherwise.
 
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