^This is a dance me and Ismene often do...
Or the brain considers it close enough to lock onto the same receptors.
I've absolutely no doubt that it 'locks onto the same receptors'. Psilocybin/psilocin is a 5-ht2a agonist, as is DMT, LSD, 2C-B, mescaline, etc. Most typical psychedelics agonise 5-HT2A (amongst other receptors). Its thought that effects at this recpetor is what causes one to trip.
According to you, mushrooms and moclbemide create an oral DMT trip, so the above bit doesn't make sense
Let me explain it again. You can take mushrooms two weeks in a row and notice effects. Agreed? However oral DMT drops off massively if you take it two weeks in a row.
So what do you think happens when you take mushrooms and moclobemide two weeks in a row? Yep - you've got it, the effects drop off massively. Just like with oral DMT.
So what's happened to the psilocybin? Why arn't you getting psilocybin effects in the presence of moclobemide? Why only DMT effects?
I'm sure you are aware of what physiological tolerance is, but in case your not, the brain adapts to the presence of drugs by downregulation of receptors. This essentially means that there are less receptor sites for a molecule to bind to, thereby decreasing the effects of the drug in question. Another form of tolerance is a decrease in enyzmes responsible for metabolising a drug, which once again, leads to decreased effect of the drug. Psychedelics are known for causing very quick tolerance. An argument could be made that combining MAOI's with certain drugs will cause a greater tolerance, as more of a MAO-inhibited substance will reach the brain, plus the natural catecholamines such as serotonin and dopamine will have had their effect increased and potentiated leading to further tolerance.
There is anything magical or mysterious going on here. You are describing tolerance.
But once again, you are mentioning DMT here. The truth is, and this is not subjective but a plain fact; if you do not ingest DMT, you cannot feel the effects of it. If you ingest psilocybin/psilocin with a MAOi, you do not feel the effects of DMT, but you do feel the effects of psilocin/psilocybin potentiated. The human body does not have the ability to break psilocin down into DMT. Once again, if you have not ingested DMT you cannot feel the effects of it.
so I'm unsure how you can draw the conclusion you have ("it simply doesn't work").
Well, I'm saying the psilocybin doesn't work. How come you can trip on psilocybin two weeks in a row but if moclobemide is present you can't? You're claiming moclobemide makes no change to the psilocybin so therefore you'd trip balls on the psilocybin. Right?
No, I'm not saying that. Moclobemide, as a molecule, does directly not interact with psilocybin. Moclobemide interacts with the monoamine oxidase enyme group, by disabling it temporarily, allowing increased levels of certain chemicals, including psilcybin.
Moclobemide doesn't inactivate the actual psychedelic chemicals of these drugs
Yeah it does. If you take psilocybin two weeks in a row you trip your nuts off. If you take psilocybin and moclobemide two weeks in a row you notice no psilocybin effect whatsoever. Regardless of the amount of psilocybin you take you remain stone cold sober. There is no psilocybin acting in your body. Moclobemide clearly has a massive effect on psilocybin and it's effect on the human brain.
Of course it has a massive effect on the brain. It increases many of the basic neurotransmitters.
you remain stone cold sober
I thought you said that you experieced mild DMT effects. Thats not sobriety.
The reason why the effects decrease is most likely due to physiological tolerance.
1) Psilocybin by itself works two weeks in a row.
2) Oral DMT and moclo doesn't work two weeks in a row
3) Mushrooms and moclo doesn't work two weeks in a row.
Can you explain this? If, as you claim, it's just "psilocybin potentiated" then it would work two weeks in a row wouldn't it?
Not neccesarily, and evidently not, because it is potentiated psilocybin. Drug tolerance- read up on it.
Saying that using MAOi and mushroom is a good way to get used to oral DMT is illogical, because they are different drugs.
Only in the sense that one has far less nausea. If you like vomiting while experiencing DMT then ok. I'd prefer not to vomit while experiencing DMT. I believe this is because oral DMT rockets you to the peak within 30 mins while with mushrooms it takes 90-120 minutes for the DMT to reach peak concentration.
Again. If you take mushrooms, you are not going to feel the effects of DMT, unless you have consumed DMT also. DMT and psilocybin/psilocin are different drugs. Psilocybin/psilocin do not turn into DMT.
What you are doing is conflating psilocybin/psilocin with DMT. Its a logical infallacy based on your perceived experience of each drug causing the same effects. I'm not arguing that they don't cause extremely similar effects, just that they are indeed two different drugs and that psilocybin doesn't metabolise into DMT in any conditions, therefore conflating shroomahuasca with ayahuasca is a definite untruth .
We'll have to agree to disagree on that one then willow. I've taken morphine and codiene orally and I'd be hard pushed to tell the difference between equivalent doses. Particularly low to medium doses. I only notice anti-histamine effects or "nods" when I've taken staggering doses of codeine.
This is purely subjective. I, personally, can distinguish between codeine, morphine and heroin, simply because I've used them many times. Other people may not be able to.
By the way, your not ever going to get antihistamine effects from an opiate; generally, they release histamine.
Thats three drugs....
I think we are actually talking about different things here. I'm saying that 4-Ho-DMT isn't DMT, and when taken orally with a MAOi, it doesn't chemically change into n,n,DMT. I think that you're saying that the effects are the same, despite the chemicals being different.