In my experience, out of body experiences have been both beneficial and destructive in my life.
Said experiences gave me a feeling that not all in life is completely meaningless or knowable. It was one of the catalysts that changed me from an Atheist to an Agnostic. So, it gave me comfort that I do not know everything there is in life, and therefore do not have the authority over the unknown such that I can compartmentalize it.
The downside of said experiences was that I would astral project at random, sometimes when I was at work. It was debilitating. I could not function in normal society because I was afraid that reality would dissolve out of thin air, and I would suddenly not be able to comprehend my native tongue. The medication I was put on was supposed to help (especially the clonazepam), however it simply exacerbated the problem, because once I became hopelessly dependent on benzos, whenever plasma concentrations of said drug dipped below a certain threshold, I would fall back into my own hell.
Fortunately, given enough time and enough mind-numbing drugs in consistent quantities, my experience of reality was continuous and convergent with most others. When I lost the fear of astral projection, I seem to have permanently lost the state of mind that is needed for it to occur spontaneously, such that I no longer need any drugs to be normal. Of course, I still imbibe in pleasures.