Other Drugs Project #1 of 2.

[SpeedLimit55]

TripDoc and I were talking in #OD the other night and we came up with an idea.
We were talking about how opiates are (in our eyes) the must useful, diverse drugs there are. Sure this may be a matter of opinion and arguable, but we feel that to be the absolute truth.
We then started talking about the different combinations we use, and about various other Opiate topics.
As we started talking more and more about how to get the most out of an opiate experience, I had a brainstorm.
Imagine a drug that worked in the same way as MDMA...only it floods the brain with endorphins.
Sounds delicious, huh?
So this is our new project. Sure it's not something that we'll be actually *PRODUCING*, but it IS an interesting idea to toy around with.
So post your suggestions here. How could we make this work? We need suggestions, comments, complaints, questions, possible problems, ANYTHING.
Here's what we've got so far (VERY BRIEF).
This new drug, we'll call it MER (Maximum Endorphin Release).
The first problem I had with this idea is the 'crash'. In much the same way MDMA depletes seratonin supplies, ideally, MER would delete the endorphin supplies. This means the 'comedown' would be increasingly painful...even the slightest bump or cut would send searing pain throught your nervous system.
What's the obvious cure to this?
Opiate agonists. You could drop your regular 'recreational dosage' and that would take care of the pain.
Of course this presents a huge problem of the addiction/physical dependancy on Opiates, but we're all addicts anyway, right?

So what's next?
We have to discover how long it takes your body to produce more endorphins. This would help us gauge when and what amount of opiate we would need.
What about pre-loading? Would it be possible for us to pre-load our bodies with an endorphin producing drug?
Serious risks/dangers?
And, most importantly we have to discover what, if any, chemical(s) do this job.
As I said this is in the drawing stages...so I'm giving you all a pencil...we want YOUR imput!
[This message has been edited by SpeedLimit55 (edited 04 September 2001).]

 

[TheTripDoctor]

There are a few interesting clinical actions i want to find a drug that produce, namely a drug that will, in the spirit of an ssri, cause natural endorphins to be more effective, an SERI, if it is possible to inhibit the uptake of endorphins, assuming they do uptake into an axon, you could have a nicer anti depressant, or at least one that helps the endorphin deficient, and not just the serotonin deficient, as these 2 are the most prevalent in the depressed.
The next as speedly mentioned, is a drug in the spirit of MDMA that would cause a flood of natural endorphins to rush the receptor, this in effect would be way more potent and euphoric than abusing at a recreational dose, any current opiate even oxymorphone. The catch is you would have serious withdrawl afterward and would need to use an opiate agonist like oxycodone or morphine to keep your brain from suffering psychological damage as this clinical condition could cause.
The next clinical activity i want to produce would be to increase in supply the natural endorphins such that it would help you to be naturally more euphoric or at the least, feeling normal. This could be usefull in the depressed as well as in addicts in remission, and in an afterward regimen for the prementioned endorphin flooding drug.
All these clinical actions currently have not been produced as far as i know or not even researched, so we are researching them ourselves. If you have anything you know or have read that will help, please contact me or speedly, i am always on aim and can always talk since im always here

Hopefully this research will provide a lot of people a real imporvement in how they feel day to day, particularly the seri, which we know is an effective way to increase the amount of neurotransmitter present in the synapse. The precursor chemical or food would be helpfull to keep the amount produced high enough, and the mdma like drug would be our little toy for fun which i doubt we even need or will ever produce, but its a nice thought.
Thanks
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~The Recreational Pharmacist
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FUCK plur
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AIM: TheTripDoctor

 

[Quirks]

In my exp. k greatly potentiates opiates...

 

[SpeedLimit55]

^
|
?
We're all anxiously awaiting the point of your post.

 

[Quirks]

It has to have a point? I guess the point is endorphins aren't the only way, and maybe not the best way, to potentiate opiates. And you guys seem to be thinking fairly narrowly about what opiates and endorphins are and do int he brain.
There's two obvious things which stimulate the natural release of endorphins. Hard exercise and sex. Ever see permanent midnight and his little jogging on heroin thing?

 

[SpeedLimit55]

Apparently you don't understand.
We don't want to simply augment opiates.
Think of it like MDMA...it FLOODS the brain with seratonin you already HAVE.
Our goal is to have a substance that will flood the brain with Endorphins.
Endorphins and Opiates are two different things...Try reading the post again.

 

[sunstroke]

Don't extremely hot chili peppers get the Endorphins flowing ?

 

[sunstroke]

Hotness in peppers is determined by the amount of capsaicin present. Capsaicin, an acrid, volatile alkaloid and an ingredient in antidog, antibear, and antimugger sprays, is a general irritant that attacks any tissue it contacts. Some police departments even use these sprays to incapacitate violent suspects. This leads to the question of why many people love to eat 'hot' peppers. Eating chili releases neurotransmitters. These proteins cause the sensations of burning or pain. The body responds by increasing heart rate to increase metabolism and by increasing salivation. Endorphins are also produced by the body in response to capsaicin, which may account for the feeling of pleasure and well-being sought by 'chili-heads'.
it was scientifically discovered that peppers had an aphrodisiac effect on water fleas. From there, it was discovered that pepper eaters are attracted to a sensation which produces endorphins, and this sensation builds up tolerance, so the poor pepper eater, once smitten, is forever seeking hotter sensations and a bigger endorphin turn-on!
So now you have actual scientific proof. Chili peppers are, in fact, addicting. You'll probably rather not know why, but here it is anyway. When the capsaicin in the chili comes in contact with the nerves in your mouth, pain signals are sent to your brain. In reaction to this threat, your brain releases its natural painkillers, which are endorphins, which in turn create a feeling of well being. The more spicy food you ingest, the more endorphins are released. The result is a warm, pleasurable feeling that all true chile-lovers learn to crave.

 

[min]

Your idea sounds interesting, but I feel that I need to make a few comments.
1.) Endorphins are normally only released during moments of great bodily stress, i.e., great pain, though they're also released during orgasm. ;-) I think that finding a way to spontaneously release them without a corresponding "necessary" stimulus would be difficult.
2.) Since opioids "latch on" to the same sites that endorphins/enkephalins do, there's a good chance that they'd be cross-tolerant, which might ultimately defeat the purpose--esp. since there are many opioids far more powerful than our own endogenous endorphins. Why release them endogenously when you can apply a more potent substitute?
3.) Lab studies have shown that endorphins are just as addictive as opioids. They found this out in the course of a series of experiments, in the hope that endorphins would somehow lack the addictiveness of opioids, but give the same effects. It was a failure.
In short, a drug that could spontaneously release large amounts of endorphins would probably be tremendously euphoric--and proportionately more addictive.

 

[Brainrape]

Wow, that was a great fucking idea, I researched endorphins a few years back in high school on a project, wondering about the same thing, how can I get real fucked up on them... but some problems might occur, and it might have already been done to an extent, if I remember correctly...
First of all, Endorphins are like god's gift to man, they do lots of shit, along with give you pleasure, they enhance our immune system and reduce aging in the body, release anti-stress hormones...so your pill would be the wonder drug of the fucking century, Ecstasy times 20, because it would be so benefical...and of course it would be scheduled immediatley

I think there are something like 20 or so different endorphins in the body, the one you would want to concentrate on is beta-endorphin...
Here is a problem though: Endorphins can't work for a long time because our body produces shit called endorphinase (sp?) that replaces the endorphins...
But awhile back some med school in Chicago figured out a way to block the release of endorphinase and thus, make that endorphin rush last longer...
Which is basically what you want, except thier shit doesn't trigger the relase of endorphins initally. Which is the first step...
So if you did some research and were able to find out what they used to block the endorphinase from killing the endorphins, combined it with somethng that would trigger the release of endorphins at a great level, you would be set.
Fuck if I know of any chemical that will trigger the relase of endorphins, reseearch the shit in chicago, and good luck.
Brainrape
PS- Endorphin is abbreviated from 'endogenous morphine'...makes sense to me.
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Lying on the stained wretched sheets with a bleeding virgin, we could plan a murder or start a religion...

 

[SpeedLimit55]

Great work guys. Interesting stuff to think...and have wet dreams...about.