Ostarine

[interleukin]

So this drug seems to available in the grey market now. Anybody here plan on running it? All the studies for this drug seem to have been done on old people at sub bodybuilding doses (3mg - http://phx.corporate-ir.net/phoenix.zhtml?c=148196&p=irol-newsArticle&ID=940363&highlight= ) while people are reporting that good anabolic doses are between 15-30mg/day.
I think I'll wait for a couple of months and blood work from other people before trying it out. I have some AAS experience but have never used anything like this or S4. Something equal to running a moderate dose of test minus the shutdown and BP increase sounds amazing.

 

[theartofwar]

I'm a HUGE fan of SARMs S4 - so when I head this shit was coming - here is all the research I've found online:

Ostarine ((2R)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide) (also known as MK-2866) is an investigational selective androgen receptor modulator (SARM) from GTx Inx, for treatment of conditions such as muscle wasting and osteoporosis, formerly under development by Merck & Company.[1]


Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTx Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,[1] using the non-steroidal androgen antagonist bicalutamide as a lead compound.[2]

Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.[3] This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.[4]

 

[p-mo]

For those that don't know- S4 is a more androgenic substance whereas Ostarine is almost purely anabolic. Its like comparing Winstrol to Anavar...

 

[daveblacktown]

I feel wary about the S4 Andarine as people have experienced side effects regarding their vision in the dark, from what I have read S4 works quicker but is more of a muscle hardener than a muscle builder and has and Ostarine takes a little while longer and is better for building mass, with no vision side effects. I read also that Ostarine lowers your resistance to insulin and lowers both HDL/LDL.

I managed to get some Ostarine Mk-2866 and have been using it for for 3 weeks now. I started off taking 5mg per day for the first week then bumped it up to 10mgs for the next two weeks and have decided to increase to 12.5mgs next week. It hasn't made me gain any weight but my body composition has definitely improved and I feel stronger in my workouts. I don't really think it has increased my appetite or libido very much. I am happy with my results so far and would consider using it again sometime in the future.

Interesting reading on sarms:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072879/

 

[theartofwar]

Well I'll tell you this much, S4 made night driving damn near impossible @ 50mcg 25 / 25 am pm - I liked it , but honestly I just don't see the point of either. The prices are absurd. I would never post a price - and do not fucking PM me - but the price at rep RC chem places for S4 / ona is literally a 12 week cycle for me EASILY. If not longer - and those of you who know me - know I prefer hefty cycles , then back to TRT.

 

[phactor]

^^^

the price is absurd. However, I still freak out about shutdown and this supposedly does not cause it. I guess I worry that I will not be able to properly do a PCT even though it seems simple enough (acquire RC SERM)..

Anyways, I know right now the main thing for me is to keep eating and lifting. I have some more catching up to do since my last (and hopefully final) binge.