• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Oral 5-MeO-DMT with RIMA

Rorthron

Rorthron

Bluelighter
Joined
Aug 25, 2009
Messages
251
Location
The Land of Midnight
It is somewhat "common knowledge" that 5-MeO-DMT can produce very bad symptoms when ingested orally with a RIMA. However I only found a couple of reports on the subject on Erowid and on the 5-MeO-DMT B&D thread here on PD.

However, IMO, 2 reports can be meaningless. Can be 2 adverse reactions overly popular that generalized into a common "urban psychedelic myth"?

Dyplopterys cabrerana (chaliponga) has a measurable amount of 5-MeO-DMT and is consumed in Ayahuasca in the Amazon and no news of adverse reactions exist. I also read of other people, unfortunately without written published reports, that have taken it without too much of an inconvenience

Some of the questions I've been struggling with are: What are the metabolic pathways or biologic processes that can produce such toxic effects from this substance, if when smoked, despite the intensity of the experience, it does not appear toxic?
Are there any academic published references on the subject?
Could there be mitigating substances in chaliponga that may reduce the eventual toxicity of 5-MeO-DMT?

I've also read of of warnings about possible acute hypertension on RIMAs + 5-MeO-DMT. What may cause it?

thanks for any help on the subject
 
5-HT is a vasoconstrictor and DMT does not have an oxygen at the 5 position, whereas 5-MeOdMT (obviously ) does. For comparison look at the reports of the effects of bufotenine (5-OH DMT) - it has all the characteristics of a hypertensive attack, implying that the 5-oxygen is required to produce vasoconstriction

Besides, 5-MeODMT is a poor replacement for DMT (a bit like seeing red biddy - meths & red wine - as being the same as a fine alcoholic drink. They both contain ethanol, but I know which one I'd choose)


It is somewhat "common knowledge" that 5-MeO-DMT can produce very bad symptoms when ingested orally with a RIMA.
Click to expand...

Personally I wouldn't describe it as pleasant when smoked or injected on it's own, never mind with a MAOI! (I really don't like any 5-methoxytryptamine derivative)
 
Sorry I have nothing to contribute, I just wanted to add that for me....5-MeO-DMT is nothing but bliss and definitely is what I choose when it comes to choosing (and the choice is DMT or 5-MeO-DMT.)

I've had some amazing experiences with DMT, but never the ++++ mystical experiences I had all three times I smoked 5-MeO-DMT. If there ever was a sacrament psychedelic in my book, it is 5-MeO-DMT.
 
Ah that's different to my experiences. I love the effect DMT has, but I once IMed 5-MeODMT and I got into a state where I could feel my ego being dissected and pulled apart in a slow enough way for it to be terrifying. Never touched 5-MeODMT since
 
I've never IMed it, but the one time I snorted it....the effects were EXTREMELY unpleasant. I can imagine that IMing it is very similar (in the same way IMing vs snorting DPT and other tryptamines is similar).

When IMed (or snorted) the ego is there to resist the effects, causing panic. When smoked, there is no time for the ego to get in the way. It is a night and day difference.

I don't recommend people use drugs...the sober life is best.

But it is a shame to write off the material without having smoked it, as it is an entirely different experience. You should consider this. :)
 
You must log in or register to reply here.
Top