The Holy Quadruplty
Bluelighter
- Joined
- Feb 9, 2022
- Messages
- 704
Can you name some opioids that're also NMDA antagonist? I'm pretty sure Buprenorphine is one right? I know Methadone, and Tramadol are as well.
Are you sure that Buprenorphine doesn't, because I've heard different? That's one of the main reasons I made this thread to get all of everybody's thoughts on it. So thank you for your answer, and yes I heard Demerol has NMDA antagonist effects as well.Lydol(Pethidin,Dolargan,Demerol) i think(but not sure).Alwful opioid for me....good combo(but dangerous)with meth.Cholinomimetic for sure along with opioid activity ...there's other too,but don't remember.Bupe is not NMDA antagonist,vut methadone is.DXM is with such properties also
Calcium is involved in many things in biology but yeah, I think NMDA receptors, among others, modulate calcium influx into neurons.Doesn't calcium have something to do with recreational feelings, or something like that?
Why u take promethazine?Bupe itself got the ability to work better in low doses and tolerance developes slowly.(at least for me)....u got Xanax for boost.....less different substances u take better.....'cause the probability of cross reactions is lessWas taking Promethazine which has NMDA antagonist effects with my bup. I also took, and take Chlorpheniramine, Xanax, and smoke weed with my Subutex. I need to see my doctor for my next refill since I got a new doctor, but when waking up at nighttime so haven't been able to reschedule a new appointment yet so out of promethazine till then.
The alkaloid Rhynchophylline but I reckon it really depends on how much of it is present in a particular batch of Kratom. Though I don't think it's a very strong antagonist.I believe Kratom has some NDMA agonism. I know people use it to potentiate or reduce tolerance/withdrawal effects.
Yeah if they let it dry in the sun for too long it turns straight up brown. Supposedly increases one specific alkaloid by a small amount making it better for pain but hardly any psychoactive effect. The whole thing about "strains" is basically a myth though, the same plant can produce leafs with red or green veins. Vendors just try to make it sound more like cannabis with a variety of effects when really kratom is just kratom, it's either good or bad. And some vendors I feel purposely make bad strains like these browns, which might work alright for a newbie but any veteran will get no effect from them.When i used to drink Kratom always preferred dark green stuff labeled as Red Borneo(or Green Malay)...never tried brown Kratom,but i know,that they sale such thing.
During withdrawals either benzo or opiate the NMDA receptor is flooding our brain with excitatory cells. GABA being inhibitory and calcium and glutamate being excitatory. Calcium and glutamate is very important for us, but while we’re withdrawing. They kinda suck lol. Gabapentin and Pregabalin are actually calcium channel blockers and that’s why they are reported to be helpful during a withdrawal.Doesn't calcium have something to do with recreational feelings, or something like that?
Docs can take the piss and big up tramadol's NMDA antagonism (it is shite at both, mu opiate and nmda antagonist). Dihydrocodeine (in fact any opiate with the double bond reduced to saturated has some NMDA antagonism).Methadone, levorphanol, ketobemidone - or at those are the 3 that are given because the NMDA activity gives more analgesia.