Opioids Opiates Dermorphin & Deltorphin found in Giant & Wax Monkey Leaf Frogs!

[purplehaze147]

Dermorphin is a super agonist of the mu-opioid receptor. This means it creates even more of a response than beta-endorphine & morphine! Deltorphin & deltorphine-1/2 are super agonists of the delta-opioid receptor. Native tribes in South America use the secretion from these frogs as an intoxicant to improve their endurance while hunting. Native Americans have discovered some cool drugs before including DMT, mescaline, cocaine, LSA, nicotine, & used psilocybin containing mushrooms to name a few of the drugs they discovered, they were very trippy people.

I bet it would be a very recreational drug maybe even better than morphine since it provides more of a response at the mu/delta-opioid receptors & lacks selectivity at the k-opioid receptor which produces a dysphoric feeling when selective k-opioid agonists are administered. The chemical structure of dermorphin & deltorphin are very similar to the endorphines found in our brain unlike morphine (which mimics endorphines) & activate the receptors even better than them!

I doubt anyone reading this thread has ever eaten the wax secretion from a wax monkey leaf frog but I'll ask anyway. Has anyone ever done this or tried dermorphin? If so how did you take it from the frog? How much did you take? What were the effects like & how does it compare to morphine, heroin, oxycodone etc.?

 

[sekio]

I thought I read there was some dude out there who was burning himself and rubbing frog venom into the blisters. I think it was known as sapo.

http://www.erowid.org/animals/phyllomedusa/phyllomedusa_article1.shtml

It sounded about as much fun as... well. Let's just say it doesn't seem like a fun Saturday evening activity.

 

[sailor bugg]

Was there a Vice Pharmacopia episode with the host trying this? (He tried some sort of frog excretion and the word Sapo rings a bell).

 

[Johno88]

Sapo means frog in Spanish I think.

 

[brandinooooo]

I thought I read there was some dude out there who was burning himself and rubbing frog venom into the blisters. I think it was known as sapo.

http://www.erowid.org/animals/phyllomedusa/phyllomedusa_article1.shtml

It sounded about as much fun as... well. Let's just say it doesn't seem like a fun Saturday evening activity.

P. Bicolor venom contains DMT, Bufotenin etc...

I'm very interested in the other frogs OP listed though

 

[donkeyPUNCH]

this is quite interesting.

I wonder if you can bang it?

 

[purplehaze147]

I found another report besides that erowid report (I read it on erowid a couple years ago & forgot all about it I didn't realise it was about a phyllomedusa frog from the same species).

"Nothing at first, then slowly an opiated high creeps over me, a drunken-headedness—it feels good. I ask for another burn. I scream. More jelly. A tremor begins passing through my extremities and wells up in my hands and feet. Wile E. Coyote earthquake-pill archetype. I request a fourth burn—more Sapo than the Captain. Who’s the mujer now? My blood pressure is climbing; my hands are going numb. Burn. Scream. More jelly. I close my eyes and feel myself collapsing into two dimensions, only to be stretched back into 3-D. Colors look desaturated. I am very high and need to lie down. The people surrounding me fan me like I’m an emperor. I lie shirtless on a plastic tarp, my stomach in excruciating pain. The frog and I exchange a glance." He goes on to say he would repeat the experience.

Supposedly it's a opiate feeling with psychedelic & dissociative properties. The burning feeling all over the body from the erowid report described as a niacin overdose is probably do to the antihistamine rush that even morphine gives. After I.V. morphine I've felt an overwhelming painful feeling of pins & needles all over the body on a couple occasions.

I don't think burning yourself would be required.