Opiates depotentiated by Lyrica

[cwill127]

Does anyone know if Lyrica depotentiates opiates? I have personally noticed diminished effects in opiates when on Lyrica at the same time. Thanks for any feedback

 

[Pilll_head]

I take 300 mg Lyrica a day, haven't noticed any difference compared to before. I read the pharmacology of it on Wikipedia, I would think if anything it would potentiate not depotentiate. Lyrica gets metabolized fairly quickly, if you took it 6-8 h before the opioid that would lessen any potential interaction than taking them together.

 

[HeadHigh]

When i take Lyrica, it greatly potentiates my opiates and opioids.