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Opiates as a superior anxiolytic

K

Kitime

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Joined
Sep 9, 2009
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9
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Does anyone find that Opiates are superior to SSRIs/SNRIs and especially Benzos in controlling anxious thoughts? I've been self-treating my anxiety with opium/pod tea and I have to say it's so much better than anything else.
 
Obviously, but ever increasing dosages and the fact that you must reach a euphoric recreational dose to control anxiety makes it a hopeless prospect to the established medical community with the current pressure from the US DEA.

Arguably benzos have less side effects in the long term treatment of anxiety though it is definitely debatable.
 
um yea.....I think most people find that anxious thoughts tend not to creep into your mind when under the influence of a euphoriant.

Obviously in the short term opioids will banish pretty much all negative thoughts and emotions......short term.

Just realize that there is only one way that your self-treatment of anxiety with opioids will end up- Addiction.

And once you're addicted, your anxiety will be 100000 times worse when you arent under the influence of opioids, and very soon, even when you are under the influence of opioids you will just feel blah and dead.

So yes, opioids will very likely alleviate your anxiety for perhaps a few months, but you will end up in a MUCH worse place then you started.

Also, using opioid to treat anxiety is a bit like using Shaq's cock to bang an Asian girl-its just overkill.

There are many medications which will effectively treat anxiety that wont lead you down the guaranteed road to junkyville that opioids will. Obvioulsly benzos are not without their dangers, but used as prescribed by a doc, they are far less liable to fuck your life up.-DG

EDIT: By the way, this thread is about as out of place in ADD as Shaq's cock would be attached to an Asian guy.
 
theWorldWithin said:
Obviously, but ever increasing dosages and the fact that you must reach a euphoric recreational dose to control anxiety
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I guess that's true in the long term, but benzos are supposedly short-term treatment as well. I figure 15mgs of hydrocodone (which is hardly a euphoric dose, but certainly enough to control anxiety, although this is subjective) to a non-tolerant person on a short term basis could be beneficial while minimizing addiction potential, but you do have a point: the DEA won't see it my way.
Arguably benzos have less side effects in the long term treatment of anxiety though it is definitely debatable.
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Well, benzos certainly have an addiction/tolerance potential as well. If we're risking addiction and tolerance, why not use something more efficient? Because it's euphoric? Benzos don't quite have the same euphoria that opiates do, but arguably the same "reaching a euphoric dose for anxiolytic effects" could be said for them. In any case, the point is moot due to DEA. Thanks for your input.
 
daddysgone said:
Just realize that there is only one way that your self-treatment of anxiety with opioids will end up- Addiction.
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What happened to responsible drug use? I've been using opioids on and off for quite a while and yes, I do feel the urge to splurge once in a while, but addiction is hardly the only end result.

Also, using opioid to treat anxiety is a bit like using Shaq's cock to bang an Asian girl-its just overkill.
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Nice analogy :P

EDIT: By the way, this thread is about as out of place in ADD as Shaq's cock would be attached to an Asian guy.
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Honestly, I made this thread pretty much to get out my first bluelight post. in hindsight, I should have went with the introduction thread :P
 
Kitime said:
What happened to responsible drug use? I've been using opioids on and off for quite a while and yes, I do feel the urge to splurge once in a while, but addiction is hardly the only end result.

Well, you are only "not addicted" until you become addicted. The fact that you arent yet, and have thus far been able to use responsibly, does not at all mean that this will continue to be the case.

I myself used opioids "responsibly" for over 2 years until I eventually slipped into the addiction Id been "putting off" for so long.

Obviously one can become addicted to any drug, but I strongly believe that opioids are unique in this respect- there is a reason that opioid are used as the model drug for physical addiction.

There just is no real way to use opioids with any regularity without addiction resulting at some point. Sure, there are tons of people who have used opioids every once in awhile and never developed addiction, but thats not what Im talking about, and thats not what your situation sounds like.
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daddysgone, there are plenty of people who use opiates regularly to get high and avoid addiction. In fact the big bad heroin has only a 10 percent addiction rate across the board for all who have sampled the drug. You are correct though, if you use them as a crutch for anxiety on the regular you will most definitely get addicted (same for benzos though).

Here is the issue in a nut shell. Even when you use benzos infrequently in order to really abolish anxiety completely you have to take a stupefying dose that alters your cognition and personality for the worse. Opiates will shatter all anxiety and leave you functional, for some even enhanced mentally.

I think opiates are a great treatment for anxiety during a 'big moment' that is seldom and crucial (dream job interview, wedding, testifying in court, etc.) but benzos are more manageable for regular background levels of anxiety.
 
Yes, some opioids have profound anxiolytic properties, even if it is only a by-product of the euphoria. As mentioned, they cannot be used regularly without addiction.

Even if I spent one day a week using opioids, I would be thinking about that coming day for the rest of the week. I know this because I have experienced it...
 
theWorldWithin said:
daddysgone, there are plenty of people who use opiates regularly to get high and avoid addiction. In fact the big bad heroin has only a 10 percent addiction rate across the board for all who have sampled the drug. You are correct though, if you use them as a crutch for anxiety on the regular you will most definitely get addicted (same for benzos though).

Here is the issue in a nut shell. Even when you use benzos infrequently in order to really abolish anxiety completely you have to take a stupefying dose that alters your cognition and personality for the worse. Opiates will shatter all anxiety and leave you functional, for some even enhanced mentally.

I think opiates are a great treatment for anxiety during a 'big moment' that is seldom and crucial (dream job interview, wedding, testifying in court, etc.) but benzos are more manageable for regular background levels of anxiety.
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That number is true of medicinal opiates used perfectly, not of recreational users where the number is thought to be closer to 33%

Measuring addiction rates in recreational users is nearly impossible.

Whenever you start using recreational over any extended period of time, the risk of addiction skyrockets.
 
I believe I read that number from the UN report on drugs of abuse last year so I am certain it is considering recreational use, however it is probably skewed because it averages in medical users as well. The 33 percent sounds more believable to me. And yes it is very difficult to measure statistics for recreational use because of how stigmatized it is.

Assuming that the 33 percent is the correct number I will rest assured, I have a 67 percent chance of things working out. Thats better than the chances of landing a job in 2009 haha!
 
It pretty much has been adequately said here already but I think you'd be hard pressed to find someone having a panic attack while scratching their big doped up smiling face. mmmm Yum.
 
daddysgone said:
um yea.....I think most people find that anxious thoughts tend not to creep into your mind when under the influence of a euphoriant.

Obviously in the short term opioids will banish pretty much all negative thoughts and emotions......short term.

Just realize that there is only one way that your self-treatment of anxiety with opioids will end up- Addiction.

And once you're addicted, your anxiety will be 100000 times worse when you arent under the influence of opioids, and very soon, even when you are under the influence of opioids you will just feel blah and dead.

So yes, opioids will very likely alleviate your anxiety for perhaps a few months, but you will end up in a MUCH worse place then you started.

Also, using opioid to treat anxiety is a bit like using Shaq's cock to bang an Asian girl-its just overkill.

There are many medications which will effectively treat anxiety that wont lead you down the guaranteed road to junkyville that opioids will. Obvioulsly benzos are not without their dangers, but used as prescribed by a doc, they are far less liable to fuck your life up.-DG

EDIT: By the way, this thread is about as out of place in ADD as Shaq's cock would be attached to an Asian guy.
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I couldn't have said it better myself.

I, like most drug addicts, use opiates to self medicate my anxiety and depression. Doing this just caused an addiction, which in turn has made my anxiety and depression far worse than it was to begin with.

Please, in the name of harm reduction, see a doctor about being treated for your anxiety; DO NOT attempt to fix it yourself with opiates.
 
Yes, opioids (mainly mu opioid agonists, but also delta opioid agonists, enkephalinase inhibitors and kappa-antagonists ) possess significant anxiolytic effects in mice, rats and humans.

There are many scientific studies about this topic. Search by using google scholar
 
I'm trying to find the structure of these "enkephalinergic modulators" but I'm striking out. Help?

Additionally, is AZD2327 a "modulator" it sounds like a delta agonist

edit: yeah, it's just a delta agonist, if highly selective. Since excluding criteria include any history of seizure, even family history, it must still have some issues with inducing seizures.
 
It's a kappa antagonist. Look at the 2nd reference on this trial's page.

OK so lets see what people think about a kappa-antagonist with no mu affinity as an antidepressant and anxiolytic.
 
My suggestion?

READ

That reference has absolutely nothing to do with AZD2327. It's about JDTic for christ's sake.

There is increasing literature of the involvement of the endogenous opioid system in major depression and its treatment. Identification of delta-opioid receptor as a possible target in the treatment of depression and anxiety began with clinical observations that a heightened anxiety state and depressive-like behaviors were consistently noted in the delta-opioid receptor knockout mouse. A number of investigators have found that selective delta-opioid receptor agonists have antidepressant-like properties in models such as the forced swim test. In a search for a selective delta-opioid receptor agonist to test in a proof-of-concept clinical study in AMDD, AZD2327 is a potent, first in class, high-affinity enkephalinergic agonist that possesses anxiolytic and antidepressant activity in animal models. AZD2327 has efficacy comparable to diazepam and imipramine in rodent models of anxiety and depression, respectively. Phase I studies have been completed and have indicated an acceptable safety profile.
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Experimental
Highly selective delta opioid receptor agonist Drug: AZD2327
Tablet, Oral, QD
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Buprenorphine, IMHO, is a wonderful anxiolytic.

It's true that you have to reach threshold-recreational doses to feel it, but you don't have to get a nod going or anything.

If I take 8mg I have a great worry free day.

It takes around 16mg up the nose for me to get 'high' on it, and yeah I *DO* get high on bupe. I hardly take it every day though, so maybe that's why. A few times a month tops.
 
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