opiate toxicity reference???

[RiseFromRuin]

ok, i think i remember phreex mentioning opiates like hydrocodone and oxycodone and the like being non-toxic.....thing is i'm trying to convince a friend popping these isn't f'ing me up......
and if this is true...how do heroin and fentanyl OD's occur...my thinking is too much at once....and i remember vaguely some referenced study on here stating if someone was given unlimited heroin...one could progressively increase the dosage for the rest of their life with relative safety....
so yeah, i need some research ammo that says vicodin is non-toxic..that is unless it isn't..

 

[its420time]

The reason you die from heroin or from any other opiod as a matter of fact is because your heart rate slows down so much that you DIE! no toxicity, this is true, but you could still die from doing too much. I also have some trouble convincing my friends that these pills are not bad, but i say fuck'em and eat all of them myself!

 

[RiseFromRuin]

those replies were good and all, and i know about APAP toxicity....i need a web site journal reference dealing with opiates and toxicity...where's Phreex?

 

[Grand Master of Somniferon]

http://www.druglibrary.org/schaffer/Library/studies/cu/cumenu.htm
You should be able to find something that you can use here...

 

[its420time]

try this site out... http://opioids.com/

 

[fairnymph]

Opioid Neurotoxicities, from here -- you can find more references and studies at that site as well:

Their prevalence has not been well documented. There exists much interindividual variability with respect to which patients develop toxicities. Patients with renal impairment and patients on high doses of opioids for a long periods of time appear to be at a higher risk. These toxicities include hallucinations (often visual or tactile), cognitive impairment, delirium, hyperalgesia, allodynia, sedation, and myoclonus. The latter is characterized by "muscle jerking" that can be localized or generalized. If very severe, these can go on to become generalized seizures.
Systemic toxicity symptoms are: myclonus, nausea, vomiting...however rarely is there permanent damage, and any form of toxicity from opiate use (with the exception of overdose) is very rare unless you are hypersensitive or a long-term, high dose user.
Compared to most recreational drugs, opiates are EXTREMELY safe, toxicity wise. The main problems with opiates are addiction and respiratory failure from overdose.

 

[RiseFromRuin]

hey ********** (why is faynyh's name deleted?) ..your link was the most helpful, although I still didn't really find what I was looking for.....how do you qualify your last two statements....obviously it's what i'm looking for but i still need a hard reference....
thanks everyone for the help...
[ 14 May 2002: Message edited by: RiseFromRuin ]

 

[quale]

>These toxicities include hallucinations (often visual or tactile), cognitive impairment, delirium, hyperalgesia, allodynia, sedation,
Hey that sounds exactly like what I am looking for in my opiates (the nod, being high etc..).
Anyway the problem with giving citations is that it is sort of common medical lore. In fact the nonexistance of studies showing harm of these drugs is fairly good evidence of their lack thereof.
Here is one link that might help you out (only an abstract but if you want you can find the related articles).abstract
Sorry I can't help you out more now but there was a thread awhile back on opiate toxicity (and neurotoxicity) and I seem to remember some pretty good sources being posted in it.

 

[fairnymph]

As quale said, the lack of studies for opiate toxicitity is demonstrative...basically, they haven't found opiates to be very toxic, so there isn't much to write up.
My name is FAIR nymph not FAIRY nymph. That is why when you typed my name, it came up in stars.

 

[its420time]

^^ haha thats funny.