Since opiates seem to be a prime topic of discussion lately on the board, i thought i'd share some light on some misconceptions ive noticed(there has been many), and inform on some points i think should be addressed. I'm not going to get into the IV mess, since that seems to be a touchy subject recently, and is turning into a freedom of speech argument.
It's been preached time and time again that opiates are NON TOXIC, however , that doesnt mean they all are, in fact most arent. ONLY the phenathrenes (heroin, morphine, oxycodone, hydrocodone) can be considered relatively non toxic, methadone is NOT non toxic and ive seen it cause dental damage to the gums. Dextropropoxyphene is NOT non toxic and can actually slow reaction time and inhibits intelligence, this was proven in a study compairing it to hydromorphone, in which hydromorphone actually increased response time and intelligence for a time. Fentanyl i suspect is not totally non toxic but consider it much safer than most of the opiates.
When you use opiates for a long time, your natural endorphins dissapear, and another peptide increases, this peptide is an antagonist at the MU and other sites in the brain. This causes withdrawl when no opiates are used or present in the brain. THAT is dependance, that alone, that chemical change in and of itself , alone, is the WHOLE of opiate dependance, nothing more, nothing of addiction or anything else, JUST those chemicals produced as a result of constant opiate use, as a reaction by the body to balence things. Now, NO opiate is a perfect match for natural endorphins, meaning if your on any opiate constantly and your endorphins are gone, you are NOT substituting for those endorphins entirely. This has various effects on the body. Some users tend to get fairly weak as the constant antagonism of the natural peptides meant to combat administered opiates also have a stress effect on smooth muscle. To make this perfectly clear, opiates do NOT totally inhibit all the effects that these peptides cause, you will notice when you are seriously dependant and you go into withdrawl, you experience the effects of these peptides. Opiates cannot totally inhibit those effects even though you will feel better. they cant act in the exact same way at the exact same sites that endorphin (the one you all are thinking of, the nice one) does.
Over time you may notice this mismatch of chemicals to receptors, most people dont notice it and simply dont care as long as they have there drugs, myself and many others have done this.
Now, the phenathrenes really dont have a lot of damaging effects on the brain aside from any response the body may exert on the receptors as a result of all the constant agonist action, im not sure if they down regulate or not, but think along those lines. You may notice that your first time really doing a strong opiate in the correct way will give you such a euphoric feeling that you absolutely want to do it again, but i can vouch that this effect sometimes is not repeatable over and over, even if you were to totally regain all endorphins and become totally normal in that respect. The best effect simply cannot be had in some people.(Euphoria is a thing of the passed) For whatever reason, that can happen. You may consider this an adaptation to the constant use of opiates.
I can say a few things about the effects of certain opiates on endorphin levels, first, oxycodone causes a seriously fast drop in endorphins, it is very very direct in its action and the body recognizes it very quickly and responds by reducing beta-endorphin and increaseing the other peptide to counter it. Next, methadone doesnt cause an immediate fast drop in endorphin, nor a fast response to counter the opiate level. However, for whatever reason the body takes a long time to recover normal endorphin levels after stopping methadone use. As for the rest (the pentazocine classand fentanyls)Pentazocine is known to affect the K opiate receptors and could be considered fairly toxic by all sources.
I dont see much concern for fentanyl its fairly safe, IMO Fentanyl is one of the most under rated opiates, if its abuse potential and availability was higher and word spread, i think it would become the media's next "Oxycontin."
Hope this was informative and brought the thought across that, the more moderation kept, equals more euphoria as an outcome.
It's been preached time and time again that opiates are NON TOXIC, however , that doesnt mean they all are, in fact most arent. ONLY the phenathrenes (heroin, morphine, oxycodone, hydrocodone) can be considered relatively non toxic, methadone is NOT non toxic and ive seen it cause dental damage to the gums. Dextropropoxyphene is NOT non toxic and can actually slow reaction time and inhibits intelligence, this was proven in a study compairing it to hydromorphone, in which hydromorphone actually increased response time and intelligence for a time. Fentanyl i suspect is not totally non toxic but consider it much safer than most of the opiates.
When you use opiates for a long time, your natural endorphins dissapear, and another peptide increases, this peptide is an antagonist at the MU and other sites in the brain. This causes withdrawl when no opiates are used or present in the brain. THAT is dependance, that alone, that chemical change in and of itself , alone, is the WHOLE of opiate dependance, nothing more, nothing of addiction or anything else, JUST those chemicals produced as a result of constant opiate use, as a reaction by the body to balence things. Now, NO opiate is a perfect match for natural endorphins, meaning if your on any opiate constantly and your endorphins are gone, you are NOT substituting for those endorphins entirely. This has various effects on the body. Some users tend to get fairly weak as the constant antagonism of the natural peptides meant to combat administered opiates also have a stress effect on smooth muscle. To make this perfectly clear, opiates do NOT totally inhibit all the effects that these peptides cause, you will notice when you are seriously dependant and you go into withdrawl, you experience the effects of these peptides. Opiates cannot totally inhibit those effects even though you will feel better. they cant act in the exact same way at the exact same sites that endorphin (the one you all are thinking of, the nice one) does.
Over time you may notice this mismatch of chemicals to receptors, most people dont notice it and simply dont care as long as they have there drugs, myself and many others have done this.
Now, the phenathrenes really dont have a lot of damaging effects on the brain aside from any response the body may exert on the receptors as a result of all the constant agonist action, im not sure if they down regulate or not, but think along those lines. You may notice that your first time really doing a strong opiate in the correct way will give you such a euphoric feeling that you absolutely want to do it again, but i can vouch that this effect sometimes is not repeatable over and over, even if you were to totally regain all endorphins and become totally normal in that respect. The best effect simply cannot be had in some people.(Euphoria is a thing of the passed) For whatever reason, that can happen. You may consider this an adaptation to the constant use of opiates.
I can say a few things about the effects of certain opiates on endorphin levels, first, oxycodone causes a seriously fast drop in endorphins, it is very very direct in its action and the body recognizes it very quickly and responds by reducing beta-endorphin and increaseing the other peptide to counter it. Next, methadone doesnt cause an immediate fast drop in endorphin, nor a fast response to counter the opiate level. However, for whatever reason the body takes a long time to recover normal endorphin levels after stopping methadone use. As for the rest (the pentazocine classand fentanyls)Pentazocine is known to affect the K opiate receptors and could be considered fairly toxic by all sources.
I dont see much concern for fentanyl its fairly safe, IMO Fentanyl is one of the most under rated opiates, if its abuse potential and availability was higher and word spread, i think it would become the media's next "Oxycontin."
Hope this was informative and brought the thought across that, the more moderation kept, equals more euphoria as an outcome.
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
Are my posts invisible or has every fucker got me me on block? 
