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Opiate immunity possible?

well that certainly answers my question on how he rersponds to other potentially narcotic inducing agents

maybe indeed he has some aberrant gene in relation to his opioid system as he appears to be a normal responder to most all other agents

i wonder if someone in University would have interest in running some tests if they knew of such a responder...?
 
blase deviant said:
How could I tell him I have a high natural tolerance without admitting that I used them illegally before?
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One thing you could do would be to tell the doctor you're allergic to codeine. Another thing is if you're post-op just get an office/phone visit and tell them you're in a lot of pain. They'll ask you on that 1-10 scale how bad it is, and tell them the truth. Don't try to be "tough". If one doesn't work for you get them to try another medication. They'll probably first try to augment with a bunch of hydroxyzine. Whatever you say, don't mention past abuse -- in this case it's irrelevant and will hurt you.
 
OK, so if it's just opiates that don't affect me... if I was ever in a situation that I needed major surgery done, what should I ask them to give me? Would muscle relaxants work for surgery? Because I know muscle relaxants work on me.
 
just lie and say that previous painkiller treatments didn't work for you. the medical profession doesn't actually know your full medical history, they just know what is in front of them, and that is often incomplete or screwed up.
problem solved.

I wouldn't guarantee that opiates or rather opioids do not effect you,
 
Its not unheard of for people to be allergic to all the commonly used opioid / opiate drugs, although I believe it tends to be more a case of them being super sensitive to them so that the side effects are intolerable. At any rate there are patients in whom no opiates can be used, and there are procedures for getting around this problem.

When you have to operate on such a patient I believe the standard practice is to use ketamine for the analgesic, thats what we got taught anyway. So if you were having major surgery there shouldn't be too much problems.

The main situation I would see that might cause a problem if opiates can't be used would be minor surgery which is too painful for NSAIDs to be effective, but not major enough for the doctor to feel that ketamine is appropriate, like say getting your wisdom teeth out.

In this situation I would imagine they would just sedate you with midazolam or propofol and not really bother with strong painkillers, on the grounds that it might hurt, but you'd be heavily sedated and so wouldn't complain about the pain, and wouldn't really remember it afterwards anyway.

Also for many minor operations they can numb specific areas pretty well with a nerve block, which is just injecting local anaesthetic higher up the nerve and numbs everything below the injection site. So a combination of local anaesthesia and sedation would probably make up for not being able to use opiates quite effectively.
 
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due to the fact that our ancestors have been using drugs for as long as history can go back, isnt their a chance that maybe this kids ancestors did enough down the lines of his generation that evolution built up a natural tolerance or immunity to the drug?

maybe some people in his family have been addicted to opiates in the past?
 
heh ive thought that on nitrous before, and it was related to a circle that wasn't fully closed somehow. I thought I was a genius.

but seriously, could that be total delusion or?
 
I've known a lot of bipolar people that prefure cocaine and have little interest in opiates.
 
Adrenochrome said:
I've known a lot of bipolar people that prefure cocaine and have little interest in opiates.
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most bipoles like visiting their manic side and hence prefer stims

a downhead is probably associated with the concurrent depression and vulnerability in that syndrome
 
I just really really want to know why you don't feel anything TeachEm, I've heard of naturally high tolerances to opiates, but in every case there was eventually a euphoric high produced.

When you do opiates, do your pupils shrink? Do you have trouble urinating? Do you get constipated?
 
Wait sorry if you didn't already say this, but do you take any medicine regularly or semiregularliy?
 
400 mg of oxy to no effect? I don't even know what to say to that. Yes...you must have some kind of anomaly in the development of your opiate receptors because that dose should knock an elephant on it's ass.
 
It sounds like you are an ultra-rapid metabolizer. I am not sure if it is 100% known what is the direct cause of this, but it is probably that you have an overabundance of CYP 2d6 (the main liver enzyme responsible for metabolizing opiates). Also 10% of caucasions don't have 2d6, but if I remember correctly this leads to ultra sensitivity to the negative effects of opiates. Another theory that my doctor shared with me (opiates have no effect on me either) is that perhaps your opiate receptors have some kind of point mutation that makes them so specific that they only "recognize" your body's own endorphins, not allowing foreign opiate molecules to lock into them.
 
Basically, if either of us are ever in moderate to severe pain we are pretty much up shit creek without a paddle, because there are no decent non-narcotic pain killers available (at leat not in the US).

I am still waiting on the snake and spider venom pain killers that are being developed.
 
Anything said here is just guessing, we have little info to go on and what information was provided isn't good enough data to speculate upon
 
^^

Yeah, to make a firm conclusion, but we can lay out the possibilities, sorta like an episode of House except we can not do any real follow-up testing to assess which to rule out or confirm...fun and intersting to explore this in and of itself...
 
^^

i am not sure how that applies...

Psychosomatic disorder, now more commonly referred to as psychophysiologic illness, is an illness whose symptoms are caused by mental processes of the sufferer rather than immediate physiological causes. If a medical examination can find no physical or organic cause, or if an illness appears to result from emotional conditions such as anger, anxiety, depression or guilt, then it might be classified as psychosomatic.
 
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