Opana withdrawals are the most intense out of any opiate. Unlike anything i've ever experience before. I kicked a couple hundred mg/day morphine habit, i've suffered oxy and suboxone withdrawals, but nothing compared to the opana. And the sad part is, i NEVER EVEN got to the point of the worst of them. I would usually end up using as soon as humanly possible again to stop the ungodly suffering. I can only imagine how much worse it would've gotten.
This combined with the (relatively) long half life (compared to other opiates like heroin, oxy, etc), make it one hell of a fucking ride.
I just got out of detox about a week ago for opanas. I was doing easily 2-3 opana 40mg ers a day, on average, intranasally. But now that i'm over the physical aspect i'm really trying to turn my life around. I NEVER want to go back to that again, or experience that hell again. I've really been making a strong effort to not touch anything really. no drinking, no opiates, no cocaine, no molly, nada. yes its only been a week, but i've been doing what it takes. The docs still got me on subutex but unless i'm feeling a real strong craving that day i dont take it (and then i do it just for the blocking effect, so i CANT slip up). I"m doing what it takes to drastically change my life.
BUT detox was key; that physical hell that is opana withdrawal was impossible to overcome on my own. Im-fucking-possible, and incomparable to any other opiate i've kicked.
EDIT: I also want to mention that opana is one of the FEW DRUGS that i notice an EXTREME DIFFERENCE BETWEEN PILLS. Like, 2 20mg opanas do NOT compare to 1 40mg opana. I've noticed that the coatings on the 20s and 30s are ROCK HARD! yellow 40mg opanas are soft and break up very easily. Breaking up a 20 or 30 even with a clamp or strainer or WHATEVER leaves hard chunks of shells, and even getting that all broken up (what a fuckin process) snorting it still is not as satisfying, even if i do MORE. the 40mg opanas were the only ones worth it imo. at first i didnt think this, i'd disagree with my friends whenever they said something along these lines, but after fucking with the red ones for awhile i really agree. There is some difference in the makeup of the 40s and the rest of them. The only other ones that were close to the 40s were the 5mg ER pinks and they still would chunk up, the coatings in particular.
Yellows are soft, the rest of them are hard as fuck.