You're right. You still got what I was saying though. Is there a word for a substance that is poisonous to all animal or even eucaryotic species?
I don't plan to use Deschloroketamine anymore, but hearing of a drug-like substance with seemingly unspecific antimicrobial activity against virii, bacteria and protozoa has me very curious:
Why would it not harm human cells?
Is it merely a very potent immunomodulary substance? If that is the case, could it have the opposite mechanism that makes ketamine an immunosupressant?
Why has such a drug neither received attention by the pharmaceutical community, nor has been pursued by the owner of the patent?
I have a suspicion that the owner plain made these case reports up to fulfill requirements for being granted the patent. Even if some form of proof is necessary for that, the medical records could have been fabricated. I can't see his motivation for that, so if he has not, we should take Deschloroketamine very seriously because long term damage seems likely should said antimicrobial activity be elicited by O-PCM.
Can anyone supply some information on the requirements to get a patent filled?
I have another vague suspicion that deschloroketamine's effects may be similar to those of benzothiophenylcyclohexylpiperidine (BTCP) derivates which are known to inhibit trypanothione reductase (thereby being effective in-vivo against trypanosomatid diseases like Mb. Chaga and leishmaniasis, the latter of which was mentioned in the patent) and genzimidazole/benzimidazolylbenzene-sulfonamide derivates (which elicit both antibacterial and antifungal activity).
I hope someone more familiar with biochemistry and pharmacology shares my interest for this issue and could perform some binding studies of O-PCM on 3D-Models of potential targets of aforementioned drugs.
Oh and let's not forget about metabolites here. Afaik CYP2B6 should primarily be responsible for it's N-demethylation, but I'm not sure what would happen to 2-phenyl-2-aminocyclohexane from there, nor have I been able to find any information on the effects of this metabolite.