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Misc Nutmeg can metabolize into Amphetamine possibly?!

The Holy Quadruplty

Bluelighter
Joined
Feb 9, 2022
Messages
815
So I have a thread that shows the metabolites, and possible metabolites of Nutmeg in humans, and I may have another possible metabolite to add to it after reading this...

Nutmeg and mace are originated from the same fruit which are used mostly for the culinary purposes. Both have the identical properties except former is bit sweeter whereas the later provides more flavor and additional light yellow color to the foods. Nutmeg seeds are either grinded or grated just before its use. If kept in ground form then it loses the flavor quickly. Besides using as powdered solid, the extracted oil from Nutmeg seeds or mace are also used for the purpose of food flavoring. In Indian cuisine, it is normally used in the cooking of Pulao, Biriyani, Mughlai dishes, sweets and rice puddings. Throughout the world Nutmeg seeds or its mace is used in varieties of vegetarian and non-vegetarian cuisines. It is an important ingredient within the spice blend of Indian, South East Asian and Mediterranean culinary process. It adds sweet and pleasant aroma. It is the reason why this spice is frequently added to the desserts, milk, chocolate, fruits and majority confectioneries. Besides the culinary use, it was once prescribed as a medicine for the neurological problems during 7th century because it creates both soothing and stimulating actions on the brain inducing sleep. The compound, Myristicin is considered to be a psychoactive drug which possesses anti-cholenergic property also and readily metabolizes to psychedelic and empathogenic drug MMDA (3- methoxy- 4, 5, methylene di-oxy amphetamine) that further changes to amphetamine. Historically, records indicate that Nutmeg is known to have intoxicant or hallucinogenic effect. In present days it is considered to be the alternate way of becoming high. In the beginning of 19th century it was introduced as an abortifacient although present day medical facts do not corroborate with that use. But it is seen to have antimicrobial and anti-leukemic effects. It was also used in cough medicines or diet aids for controlling the obesity. Interestingly, Myristicin which bears hallucinating property also acts as good insecticide. The lignans present in the seeds are anti-carcinogenic and camphene has antibacterial and anti-fungal role. The volatile oil fraction of Nutmeg are used in the perfumery and soap or detergent making.

Nutmeg - 2


Metabolism of Myristicin to Amphetamine
I'm going to have to add this to the Nutmeg metabolites thread. It's going in the possible metabolites part for now at least.


 
Well - oxidative amination IS known to chemistry but appears to be endothermic and one would need a source of ammonia - a compound the body goes to some lengths to avoid. I believe something like 50 micromoles/L are typically found in human plasma.

A related biochemical reaction is known but that typically deaminates amino acids and yields NH4+ ions.

It's impossible to prove a negative, so Hitchen's Razor is the appropriate tool.

Wour out what studies would confirm such a reaction. But given that the allyl may well end up being oxidized to the epoxide, it's not a study I would wish to be part of.

Nobody has detected the target so maybe the answer is that any psycoactivity isn't due to the formation of an a ring-substituted amphetamine?
 
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Well - oxidative amination IS known to chemistry but appears to be endothermic and one would need a source of ammonia - a compound the body goes to some lengths to avoid. I believe something like 50 micromoles/L are typically found in human plasma.

A related biochemical reaction is known but that typically deaminates amino acids and yields NH4+ ions.

It's impossible to prove a negative, so Hitchen's Razor is the appropriate tool.

Wour out what studies would confirm such a reaction. But given that the allyl may well end up being oxidized to the epoxide, it's not a study I would wish to be part of.

Nobody has detected the target so maybe the answer is that any psycoactivity isn't due to the formation of an a ring-substituted amphetamine?
I was talking about actual straight up Amphetamine, but I don't think it does though.
 
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