Mental Health NSI-189 - the overlooked antipsychotic?

[plumbus-nine]

I know this stuff for longer now, and once in a pretty psychotic state thought that it might be the answer to my dissociative-overuse induced symptoms (that a certain vendor would stock it out of this reason; you see, common delusions stuff - but usually my delusions contain also a grain of truth), ordered some and had a pretty subtle but also pretty unique experience. If you know dissociatives, maybe you got the same 'deja-vu' or, as I'd describe it better, a sense of nostalgia, that things were once again like they were long ago, and the time of worries over, etc.pp. I even got this from DXM, above the first but below the real second plateau with double vision etc. but with tolerance it faded. NSI brought this back but with a more 'fresh' taste instead of the warm-syrup like consistency of dissociatives (besides DCK, but each of them is unique(. Nowadays I can't use DXM anymore as even just 60-80mg would trigger acoustic pseudohallucinations and at 350-500+mg full-on hearing voices which shout bad things at me. Have to say that I've never truly been convinced of being a bad guy (I'm too soft for that maybe) but I have PTSD and it's my brain mis-interpreting noise - in silence I wouldn't get bad stuff but specially driving-by cars have an aggressive undertone. Again, probably usual schizo stuff.

Now my NSI got seized, forgot why, or stolen, and I forgot about it. Years would pass, three or so, and I accepted to having fried my brain, then I finally stopped dissociatives and things began to recover, yet not completely so. Now recently I decided to order some more goodies and they happened to have NSI-189 with on their menu. Ordered a gram of it, and realize now that since and specially after redosing (10-30mg intranasally - not recommended, stick with oral) the leftover acoustic stuff is gone. Almost, but more so than ever.

Read up about it, they suggest that it causes neurogenesis in at least the hippocampus. Which happens to be a primary brain part involved in acoustic hallucinations! And those seem to be some of the most disturbing symptoms of schizophrenia, also where antipsychotics tend to fail (some can even cause it).

I can't really recommend anybody to use an experimental drug but I'd say if you underwent numerous failed attempts with established pharms and are into drugs, it won't hurt to give it a try.
But primarily hunting for other's experiences, maybe people with coexisting psychotic and depressive symptoms specially, as NSI was afaik never tried in psychosis (maybe there it's harder to convince the ethics board as psychosis is lesser understood and easier to exacerbate when it's seen as a progressive disorder while depression usually seen as a static or momentary situation)? What do you guys think about the hippocampus link?

Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia - PubMed

<span><b>Background:</b> Hippocampal dysconnectivity has been detected in schizophrenia patients with auditory verbal hallucinations (AVHs). Neuroanatomical evidence has indicated distinct sub-regions in the hippocampus, but which sub-regions within the hippocampus may emerge dysfunction in the...

pubmed.ncbi.nlm.nih.gov

Hippocampal CA1 deformity is related to symptom severity and antipsychotic dosage in schizophrenia - PubMed

Abnormalities of the hippocampus are intricately involved in the pathophysiology of schizophrenia. Hippocampal volume decrease is present at disease onset and has mainly been observed in the anterior and posterior part of the hippocampus. Nevertheless, an association between regionally specific...

pubmed.ncbi.nlm.nih.gov

Disrupted network cross talk, hippocampal dysfunction and hallucinations in schizophrenia - PubMed

Hallucinations characterize schizophrenia, with approximately 59% of patients reporting auditory hallucinations and 27% reporting visual hallucinations. Prior neuroimaging studies suggest that hallucinations are linked to disrupted communication across distributed (sensory, salience-monitoring...

pubmed.ncbi.nlm.nih.gov

Just that dissociatives aren't said to hurt the hippocampus but moreso the temporal lobe (?)
Have to say that my mother is diagnosed with paranoid schizo, yet only developed symptoms when she isolated herself, at least for as long as I can remember. She must have had more severe symptoms earlier, fuck my dad who'd nothing better to do than to make her a baby when he was kind of her coach. So maybe the dissociatives aren't the relevant factor.

 

[simstim]

Interesting. I might check it out. I've been hearing people off and on for years. For me it's always a bunch of lies and rumors. Pisses me right the fuck off.

I hate being judged by liars and hypocrites. I'm no killer but if I could get my hands on the people that do that shit and I knew I could end that kind of behavior by ending the person I'd be mighty tempted. Lol.

I have some mighty strange perspectives and beliefs on the subject that are tied into my religious beliefs. For one that the liars and spreaders of malicious rumors are the ones being judged in this instance instead of me, and according to their own measure too.

 

[izo]

i went through aboout 1-1,5g of nsi-189, all consumed nasally which didnt brought any problems with it for me. gave me a light buzz directly after insufflation and thats about it. i did not experience any nootropic effect or as youve noticed some kind of antipsychotic effect. but i normally dont suffer from psychosis and/or shizophrenia anyway.

 

[plumbus-nine]

Yeah, me too been having this on and off for like 3 years now, and it doesn't follow the scheme like most schizophrenics experience it, that there were acute symptoms in phases and leftovers in-between. For sure it's related to individual beliefs, if conscious or not. Mine is also very mood-dependent, more so than to drug use or abstinence. In some times I was still heavily using deschloroketamine and didn't get anything more than in phases of abstinence and then just methylphenidate or zoloft exacerbated it. Not just is it easier to life with anything when feeling happy, then the stuff also tends to be friendly. Sometimes I was having hour-long conversations with my voice (it tends to be just one, a second stream of thought, compared to the multiple and clearly male/female voices of stim psychosis) and they were friendly with me but when I'm annoyed by or angry on myself the phenomenon pours oil into.

Weirdest shit by far remains DXM. While I was addicted to that as an adolescent, taking like 150mg's daily for months and sometimes thinking I could only be happy while on DXM, it turned into a psychotic nightmare once I got tolerance to opioids. Can't nail it down for sure because I was also heavily using DCK and some batches were contaminated with something very toxic, but as said I couldn't work any clear relation out besides me somehow suspecting morphine even when it's said to be antipsychotic but also sometimes trippy and at 600mg/d there will be definitely some kappa activity (smoking salvia brought me off kappa as the culprit though, while smoking some indeed amplified the phenomenon, but it felt more like an echo waving back and forth within my mind (wikipedia lists hall effects among kappa induced stuff) and I felt pretty detached, differently so than on dissociative but similarly worryless and just fascinatedly listening to what strange stuff happened to the music I was listening to.

But it remains an interesting topic, one few people actually speak seriously about, be it because of stigma, bad experiences or fear thereof. I'd wish docs were more open minded but the question, do or did you ever hear voices, remains to be the textbook example for (bad) schizophrenia diagnosticity even when schizo isn't the diagnosis with most prevalence of acoustic stuff but schizoaffective disorder and maybe that's just the people who are the worst in faking to be ok. It kinda worries me that e.g. olanzapine has hearing voices listed as a common side effect, that one didn't exacerbate in me but risperidone - which induced a full psychotomimetic episode even long before any hallucinations. Parameds injected me when I was caught drunken and argued with police or somewhat, forgot full 9 days of that time but I must have been violent enough for a shitty doc to diagnose me with antisocial personality disorder when I didn't fulfill a single criteria of that disorder.

Yeah, I'm pacifist but give me power and guns and I'd go out judging some of the worse savages out there (actually I think the worst people will never face judgement, just because they don't feel any guilt or empathy, and are often enough in very powerful positions).

First (this was on an unwanted stim psychosis, these darknet fuckers delivered me some beta-ketone instead of DCK and I kept trying, DCK is one of the most stimulating dissos out there which isn't manic like 3-MeO-PCP, so I thought it was just tolerance until I read the police report) I believed the voices. They were telling me that I'd be hunted by some high profile agents because they were thinking I'd be some big dealer when in reality I never dealt at all but played with the idea of trying myself with some RC business. Had fake ID with me too because I was believing to have to face jail for repeated importation of methoxetamine and driving w/o license but didn't realize that indeed fake IDs can bring you behind bars. But well, I was in a foreign city in a foreign country hearing people shouting down from the houses (echos of cars I guess) and the sky that I need to hide, go to hospital for not getting arrested and go thorugh cold turkey etc.pp. ended up in the local psych ward but before I took all the remaining methadone, maybe 100mg when my dose was 30mg/d - slept two days, they didn't care, then I told them not to have insurance and could go.

After my rational mind reflected the stuff and eventually I trialed the phenomenon but it couldn't give me a single information, thought or idea I didn't have myself before so - but yeah it remains to be annoying and somewhat worrying.
Very thankful for the third silent day in a row, even when it's "just" weird thoughts and no more voices but NSI really seems to help. Maybe testosterone too but I'd say it is the NSI. I have a bad habit of always doing multiple things at once, or then nothing at all, be it ideas or drugs.

@izo, yeah NSI is very well tolerated. Maybe it only causes something which is saturable and is very selective thus hitting a ceiling effect at some point, I didn't read any more real information about it than that it was a purposed antidepressant which somehow development of got halted and they saw neurogenesis in the hippocampus. Whoever decides which substances end up as RCs, which as nootropics, which as drugs and which as medicine, and why... imho the better substances tend not to get approved these days.

 

[plumbus-nine]

So I can confirm that it works. Skipped one dose (it appears to have a duration which warrants twice daily, or once, as necessary) and that weird thought stream phenomenon re-occurred and disappeared again with some NSI. Substances are full of surprises but they should really trial this for lingering psychosis symptoms (guess for acute one it's too subtle but it tackles stuff which NONE of the available dysphoria inducing antidopaminergics and antiserotonergics touched, while being mood neutral).