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Novel stimulant compounds (perhaps with less spam than the 'stims of the future')

How about this methylphenidate analogue, very similar components and no record of compound in pubchem search.

Crossed between desoxypipradrol & methylphenidate
 

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Has anyone looked at BPAP or PPAP? They don't look much like the PEA-derived stimulants, but I wonder how recreational they might be.

The other stimulant that should be free of legal restrictions would be Amphetaminil, it's off the market now, but has been used in ADHD, Obesity and narcolepsy (standard procedure for stimulants, I suppose).
 
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Amphetaminil would be easy to call an analogue as it metabolizes to amphetamine i believe and the US definition is so braod using the word "similar structure"

of course you note i have already speculated BPAP and PPAP may have some real merit in another thread
 
Ahrrg said:
With a risk of making the thread more stims of yesterday, I would like to bring the subject back to zylofuramine.
FnB you wrote that you might have tasted this one, could you elaborate?
I got some time over to read the Sterling patent and the j. med. chem. papers and it seams alright, although a bit of a mess with the stereochem.
Them I found a later patent (US 3301865) were the "zylofuramine" is used a precursor for 2-benzyl-3-piperidinol compounds with activity comparable to AMP.
"2-benzyl-3-piperidinol 16 mg/kg, 1,2-dibenzyl-3-methoxypiperidine 8mg/kg, 1-cis-2-benzyl-1-ethyl-3-piperidinol 8mg/kg" Makes one wonder if these were better and lead to zylofuramine not being persued or if they all were found to be unhealty/abuse prone?
These compunds looked very similar to some old Schering substances (US 2997478) e.g. the SCH-5472 discussed i the old stims thread,(I think by haribo)....would make for some interesting patent issues by modern standards.......some further digging and I found the old J. Med. Chem paper (1968, 792-796) where these substances are descibed and tested on mice (ablite a bit rudimentary)
I also read DrHeckylls comments in the old stims thread on unreliable effects of SCH-5274, but according to the J.med. Chem paper that comment would be for the N-methyl version.
Do someone know anything more about these compounds or have the refs below (alledged to describe the clinical "trials" of the Schering compounds):
1. S. Irwin, N. Slabok, P. DeBiasse, and W. Govier, Arch. Int. Pharmacodyn.
Ther., 118, 358 (1959).
2. J. Nodine, T. Rode. J. Slap. H. Lery, and P. Siegler, Antzbiol. Med. Clzn. Therapy, 7, 771 (1960).
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After checking, sadly it wasn't one of the smorgasboard of anorectics I ended up feeding to rats
 
What is nomifensine actually like (apart from occasionally fatal)?

Oh, and has anyone pulled up the patents concerning Amineptine? That was taken off the market because of abuse. I mean, a stimulant dopamine/noradrenalin reuptake inhibitor:

Amineptine.gif


Doesn't look like it would be hard to knock up, either.

I would also like to add that F&Bs labrats must have had a short but (for a rat) interesting life...
 
Being that Amphetaminil is an approved drug in this country, analogue status doesn't apply, unless I'm mistaken. If that were the case, every doc who writes a prescription for it without a DEA number would be violating the law.

That deoxyphenobarbital drug, I think Primidone is the name, that's uncontrolled and (I think) more prescribed today than Amphetaminil is.
 
Primidone makes your body convert codeine to morphine much more efficiently doesn't it?
 
haribo1 said:
What is nomifensine actually like (apart from occasionally fatal)?

Oh, and has anyone pulled up the patents concerning Amineptine? That was taken off the market because of abuse. I mean, a stimulant dopamine/noradrenalin reuptake inhibitor:

Amineptine.gif


Doesn't look like it would be hard to knock up, either.

I would also like to add that F&Bs labrats must have had a short but (for a rat) interesting life...
Click to expand...

Yes thats an easy one, fairly available starting materials and its off patent also ;)
Probably not one for "hard stimers" although it would be fun to know if someone have a ref for some binding data?
Patent # US3,758,528 + a lot of previous and following
 
Ham-milton said:
Being that Amphetaminil is an approved drug in this country, analogue status doesn't apply, unless I'm mistaken. If that were the case, every doc who writes a prescription for it without a DEA number would be violating the law.

That deoxyphenobarbital drug, I think Primidone is the name, that's uncontrolled and (I think) more prescribed today than Amphetaminil is.
Click to expand...


good point

i did not know it was an FDA approved drug

can you enlighten me to any points regarding dose, simila effect comparisons, et al....?
 
^ You are not alone, seams to follow the zylofuramine in the increased activity with N-ethyl. Read an article about Lou Harris the Sterling guy in charge at the time and he descibed the Sterling compunds as promising and there was a hint the they where tried in clinic. But there the trail get cold. Tell us if you find anything more and thanks for the nice pics:)

Riemann Zeta said:
Well take me down to funkytown: the 2-benzyl-3-piperidinol compounds look both interesting and promising. I would love to know more.
Click to expand...
 
Yeah, it's been known to cause spontaneous orgasm, but so has opiate withdrawal, so I think any link between euphoria and spontaneous orgasm is tenuous at best.
 
i have heard about the spontaneous orgasms as well


anyone see that recent CSI NY with the woman who died from asphyxiation during a spontaneous orgasm where her inhaler cartridge was swapped put for one containing a compound that as I noted sounded like a bad MDMA analogue
 
CSI has the most ridiculous drug related stories I've ever seen. How about the one where the guy became a cannibal after ingesting PCP?
 
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