Novel mode of administration

[sarbanes]

Plugging has serious drawbacks. The emulsions containing the API can become micelles, leading to a rather unpredictable extended release, and a potential overdose when the patient is not satisfied with what should otherwise be a satisfactory dose. Re-dosing on a regular basis can suddenly land you in a coma.

A newer and increasingly popular mode of administration is inhalation of a very finely milled powder. In fact, one small Pharma is in Phase 1 of using zalpelon (Sonata, King Pharma) in their proprietary Staccato brand of the z-drug.

The benefit is nearly 100% bioavailability, and unmatched time to onset. The practice way. Have your finely milled API of choice, with proper dosing and knowledge of the API, and how it interacts with you. Take an empty cleaned out yogurt cup, and bully a small hole into the center bottom by twisting your car key. Keep twirling through until hole is just a tad smaller than the straw you will next stick in there. We want a tight fit in the yogurt's bung hole. Insert straw just maybe 1/4" into cup from bottom, so when you look into the cup, all you see is a tiny nub of straw sticking up. The cup is your cyclone chamber. You basically put the yogurt cup over your mouth, direct the straw to the API, and inhale deeply. This will get most of the powder directly into your lungs. This is the very latest MOA which has just become assessable to the masses.

 

[Runera46]

Because snorting some things wasn't painful enough already!

Personally i think i have put my lung tissue through enough already without adding inhaling fine powders :/

There are asthma products with dispensers that do this also.

 

[Jamshyd]

I'm coughing and wheezing just by reading this!

No thanks, I'll stick to plugging as I've never had any problems with it in the 8 or so years I've been doing it!

 

[PoppyLlama]

yeah this sounds TERRIBLE for you. I would never, ever, EVER do that. inhaling a powder? what are they thinking! thats practically asking someone to removed your lungs.

 

[hamhurricane]

This ROA is only being used with pharmaceuticals which are active in the microgram and single digit milligram range. It would be nightmarish to try this with, say, 500mg of mescaline hydrochloride.

 

[sarbanes]

Gosh, what must I have been thinking posting here on BL

 

[skillet]

What's wrong with plugging? It sounds slightly more straightforward than sticking a straw through a yoghurt pot then using it to inhale a tiny amount of some substance. I can imagine that some/a lot of the compound might stick to the straw or pot too. And with plugging you can use liquid measurement for really accurate dosing of potent compounds.

I don't think it's a bad idea though, just that there might be some problems with accuracy.

What's an API, other than application programming interface? If you're worried about micelles maybe you can put some surfactant in there too!?

Oh and sonata has pretty damn quick onset orally, must be almost instant knock-out that way!

 

[ziddy]

What's wrong with plugging? It sounds slightly more straightforward than sticking a straw through a yoghurt pot then using it to inhale a tiny amount of some substance. I can imagine that some/a lot of the compound might stick to the straw or pot too. And with plugging you can use liquid measurement for really accurate dosing of potent compounds.

I don't think it's a bad idea though, just that there might be some problems with accuracy.

What's an API, other than application programming interface? If you're worried about micelles maybe you can put some surfactant in there too!?

Oh and sonata has pretty damn quick onset orally, must be almost instant knock-out that way!

Active pharmaceutical ingredient. I was wondering what the benefit of this ROA with this compound would be. It'd make a lot more sense for something with low oral bioavailability.

 

[MattPsy]

Gosh, what must I have been thinking posting here on BL

:D

This method works great when in single milligram quantities and powders milled to nanometer (well, probably anything under around 1000, actually, ie. <1 micron) spheres, but otherwise is likely to cause lung damage and horrendous coughing. Not to say there's anything wrong with the method - the problems which might arise are caused by other factors.

 

[Fornax55]

Gosh, what must I have been thinking posting here on BL

because we're the most beautiful drug community in the world?

but truly, this idea sounds horrendous. i have enough of a coughing fit when powder i insufflate finds its way into my lungs.

perhaps this ROA might be used medically (though why, i can't imagine,) but i can't really see it catching on with mainstream drug users...

 

[chasing_s]

if you want a inhaled buzz, just get on a nebulizer for asthma. terbutaline nebulized gives a pretty good stimmy effect, though in general if you need it nebulized that's the last thing on your mind. I'd imagine salbutamol would do the same thing.

seems to me apart from pharmaceuticals this method is likely to be a recipe for filling lungs with crud. even smoking/vaping seems less bad for you.

 

[sarbanes]

Snip...

Oh and sonata has pretty damn quick onset orally, must be almost instant knock-out that way!

....Snip

Actually zolpelon (Sonata) is really bizarre stuff, and in multiple ways. It effects some people profoundly. Others' are barely touched by up to a gram of it (these same people effected by normal dose zoldipem and zopiclone, usually). One thing seems quite certain, either tolerance rises so fast with this one (unlikely), but rather, after several doses, it simply becomes ineffective in a sub set of patients, no matter what the dose, within reason.