Not sure what's wrong, Should I try higher doses? (oxycodone and codeine)

[entouragee]

My friend smokes Marijuana about 1 Joint or Blunt a day, and very occasionally drinks. Very healthy 6' 160 pounds, never had any health problems. His problem is that he's unable to get high from Oxy-codone/Codeine. He has only done these drugs about TEN TIMES throughout his entire life, So many of you would not call him drug 'tolerant' so I'm afraid of what dose to tell him to try.

When he first did Oxy-codone he took 20mg and got very high. The next few times he did (30/40/60)(mg) and those experiences were marvelous. Even though he has done Oxy-codone less than 10 times he no longer experiences any euphoria or any real pleasure other then just getting a bit tired. It's been 7 months since he last tried it before last week and he took 60mg again and still had no real pleasure.

As for Codeine a similar story where he has done it about four times doing 200/240/300/400, and did 400MG of codeine last night after not doing it for maybe 4 years and only felt a small buzz. WHY DO DRUGS HATE HIM???OTHER PEOPLE SAY 60MG of OXY is entering Heaven. Does he need like 120mg?

 

[effie]

Is this really about your friend? Or is this you? Own up to your own drug use

It's a little unusual to say the least for tolerance to rise so steeply and linger for so long.. maybe the magic of taking a new exciting drug is wearing off? I certainly wouldn't double your dose from 60mg to 120mg, you could overdose. 400mg codeine is equivalent to about 40mg oxycodone so 120mg oxy is a huge jump. If you didn't feel much from 60mg (and you'e sure it was oxy) maybe try 80mg.. bear in mind though that if you're already starting to need these doses after taking the drug so few times you are really starting to push your tolerance up. Maybe opioids just aren't your drug?

 

[entouragee]

ok

I think it may just be that opiates suck for me. What other kinds of drugs are safe once in a while kind of euphoria?

 

[Alex000]

I don't think opiates suck for you as you have had good, even great success with them in the past. I don't think it is you, so I have to ask are you taking any other drugs/medications? Have you lost your appreciation for them in some way? You are not tolerant to opiates because of use, because you have only used them a handful of times. So, I would NOT up the dose at all, because while the euphoria may have gone away, the CNS depression certainly has not, so upping the dose could be dangerous, even if it doesn't feel it. Keep the doses at what you have used before, and see if any more experiences are sufficient. I highly suspect there is another drug you are taking like an anti-psychotic or an anti-depressant of some sort, however, there are a number of other drugs that can "dull" the opiate high.

 

[iSTONED]

Whats your ROA with the painkillers? That could play a factor. By no means think about IVing them. But maybe you can plug them for maximal effect with out banging them. OR just try another type of opiate. Like opana.

 

[nAON]

I know that feel OP. Got horrific natural tolerance here too, first few times I used opis it was glorious, now I can barely feel anything off them, even after months of no use.

I recommend trying out some potentiators; sedating anthistamines (diphenydramine, promethazine, etc.) work well to add to the high as well as dealing with side effects. DXM and Magnesium supplements can help reduce tolerance to an extent. Benzos and other GABA drugs can also help with sedation, but they can be very dangerous to combine if you haven't had experience combining them - start on low doses, ie. if you're not feeling much off 60mg, start on 40mg with 10mg diazepam equivalent and work up from there.

 

[pally pete]

I highly suspect there is another drug you are taking like an anti-psychotic or an anti-depressant of some sort, however, there are a number of other drugs that can "dull" the opiate high.

This interests me somewhat as my Opiate tolerance is very strange, Doing 160-240mg Oxy to get where i want to be and then taking 1-2 month breaks and still needing 160mg+ to feel what i want.

Then on another occassion after about 1 month of Opiate abstinence i took 480 DHC and i was nodding like a donkey yet after that no matter what dose of DHC ive taken has even touched me!

Ive been on various SSRI's/SNRI's over the past 9 - 10 months and wonder how much this effects things?

 

[DooMMooD]

Obviously codeine is impacting you in a much lesser way. Codeine is already pretty weak, and i believe most of its good effects are a result of it converting into morphine in your body.

Everyones body chemistry is unique, and different drugs hit different people differently (eg: morphine hits me VERY HARD, i prob have closer to 70% BOA for morphine, most people have like 30%). Codeine already being weak and dependent on its conversion, probably just doesn't convert that well in your body.

Perhaps oxy too. I personally think trying different opiates might give you the results youre looking for.

But also remember, not everyone LOVES opiates. I personally do, but I know some folks who would take a stick or two of xanax over (not consiering the costs) an opana 40!!! Whereas you couldn't get me to give up an opana for 20 sticks of xanax. Everyones different, drugs hit everyone differently. Perhaps attempt using other opiates to see what the dillema is here amigo.

 

[entouragee]

Anymore opinions on this? I just took another 1 month break and 60mg made me very sleepy but no Euphoria. I'm thinking of going to 120mg is it possible I can end up in the hospital? 60mg made me very tired but not any breathing problems or something to that effect, had a little itch going but not much happiness that I look for when I do drugs once in a blue moon to relax.

 

[lman_15]

I have a friend who his first time trying any opiate did 80mg of oxy and was fine, and would occassionally do opiates and did doses as high as 240mg oxy. Not saying you should do that but some people just naturally have high tolerances to certain drugs for what ever reason.

Also, I find mindset and the space you do it in has a huge impact on what you feel. Obviously the drug itself (what drug, how much your taking, and your tolerance, last use, etc.) influence the high, but your expectations about what your supposed to feel greatly influence what you do feel. We expect not to feel much you probably won't. The mind and your mentality can do a lot. Also, some situations I enjoy more on opiates and get more out of opiates while on them. So try to find situations and things that would potentially make your high more enjoyable. (for me opiates and fucking my girl my favorite combo). I would also look at the opiate potentiation thread to find ways to increase the effects you experience without having to double your dose.

 

[Jabberwocky]

the setting in which the opiate is taken sometimes affects a persons rush.

myself being an opiate addict for 3 years hate the fact that even after months of abstinence, i still require a huge amount of codeine or oxy to achieve any real high.

i believe it also may be due to psychological factors (the belief that you have to take more) when in reality the dose you are taking IS making you high, you just think that it isnt.

i remember when i took my first two tabs of 12.8mg of codeine, 24mg had me nodding crazy. now, i take 500mg coupled with 3mg of xanax and still it will never compare to that first high i ever felt.

what is your weight? 120mg could easily kill a small person.

like stated before, if you're looking for a nod try coupling it with a benzo, but take it easy. i have had some quite serious incidents in the past with opiates and benzos. I took 120mg of oxy coupled with 60mg of bromazepam (not advisable) and left me close to death.

i get very impatient when i'm dosing my opiate/benzos too. at the moment i've taken 500mg codeine and 2mg xanax after a two week break period. i have a strong urge to take more xanax, but have to restrain myself mentally which is quite frustrating.

 

[lman_15]

How are you ingesting oxy? orally? because the route of administration can influence it greatly as well

 

[Jabberwocky]

How are you ingesting oxy? orally? because the route of administration can influence it greatly as well

this is true too. in all my experience, insufflating hit faster, but orally the high would be much stronger. i believe there is a higher ROA through the stomach than nasal, but i could be wrong.

 

[lman_15]

this is true too. in all my experience, insufflating hit faster, but orally the high would be much stronger. i believe there is a higher ROA through the stomach than nasal, but i could be wrong.

From what I have read this is true. I think oral bioavailability is something like 10% higher than intranasal bioavailability when it comes to oxycodone. From my personal experience it comes down to a faster more intense high (intranasal) or a longer lower intensity high (oral). just my personal opinion from my own experience with taking oxy with both methods but i might be biased cuz i'm hooked on oxy myself and prefer intranasal any day over oral

 

[Jabberwocky]

in the UK we get something called oxynorm which is packed full of things that give me terrible sinusitis. oxycontin is incredibly rare to find here too, so i prefer to eat them

 

[flyonth3wall]

The best and only way you should really take Oxycodone is orally. Other ROA's are a waste in comparison, unless you're IV'ing them ( not AT ALL advisable.. ) and even then if you do IV them, there isn't much of a 'rush' from Oxycodone as you would get with some other opiates. The high is the same as oral, except it has a faster onset, but then the high doesn't even last anywhere near as long. Its a waste IMO/E. Stick to oral, its the most efficient method, and the safest/foolproof.