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Norbuprenorphine (also Acetorphine)

Norbuprenophine is a full agonist

dread said:
Norbuprenorphine is inactive or has very little activity (so little it can't be noticed). It is a metabolite of buprenorphine, first-pass metabolism converts buprenorphine very efficiently to norbuprenorphine so if you want to experience the lack of effects, just eat some buprenorphine.
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Norbuprenorphine is a full agonist at the mu-receptor. That is the support behing the theory of "less is more" with buprenorphine because by taking a small dose of buprenorphine you leave receptors open to recieve the norbupe once its metabolized.

That is why I wonder if swallowing your subs would lead to more euphoria because most of the bupe would be converted into norbupe before it ever gets to your brain, I've yet to try it but its an idea.

Also, does being a full agonist necessarily mean it causes more euphoric effects? I've never heard of norbupe being used as a pain killer so maybe it doest cause euphoria, or maybe it attaches to the receptors very poorly, for a very short amount of time, or doesnt cross the blood brain barrier well?

I just feel like if norbupe was a useful drug, recreational wise, eating suboxone/subutex would be a lot more popular by now, so either the norbupe is useless or for some reason when you swallow it it never makes it to your brain, maybe it gets metabolized further before exiting your liver? Or maybe your stomach breaks down the bupe so when it gets to your liver it gets metabolized into something useless.
 
dread said:
Norbuprenorphine is inactive or has very little activity (so little it can't be noticed). It is a metabolite of buprenorphine, first-pass metabolism converts buprenorphine very efficiently to norbuprenorphine so if you want to experience the lack of effects, just eat some buprenorphine.
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the reason for that is because the buprenorphine when taken at a dosage of >1mg binds to so many mu receptors in the brain, leaving the norbuprenorphine unable to bind, however if you take smaller doses (say 0.5 mg) more of the norbuprenorphine can bind to the mu receptors and it is a moderately strong agonist with high potency. everyone i know that i have taught this to and they tried it said that the lower dosage made it feel less like a agonist/antagonist and more like a full agonist--obviously not as strong as morphine or other full agonists, but definitely more like a good opiate buzz
try it, i bet youll be surprised ;)
 
Sounds like placebo to me.

Also if your tolerance is low enough for 0.5 mg to have any effect then of course the bupre is going to feel more "recreational"...
 
^^^ exactly. This crap hypothesis (smaller dose of bupe leaving receptors open for nor-bupe) is once again being treated as fact over in OD. I've given up trying to have a reasonable conversation with em. Again. Crimaninny!

I tried to put in terms they might understand ("you know how you feel a shot ALOT more when you are dopesick than when you are already saturated with dope? This is why you feel lower doses of bupe more!) but I quickly got deluged with cries of heretic and traitor. Like trying to reason with a ...errr, nevermind.
 
amanitadine said:
^^^ exactly. This crap hypothesis (smaller dose of bupe leaving receptors open for nor-bupe) is once again being treated as fact over in OD. I've given up trying to have a reasonable conversation with em. Again. Crimaninny!

I tried to put in terms they might understand ("you know how you feel a shot ALOT more when you are dopesick than when you are already saturated with dope? This is why you feel lower doses of bupe more!) but I quickly got deluged with cries of heretic and traitor. Like trying to reason with a ...errr, nevermind.
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I have to disagree, I thought that might be the case, but I went on for several months taking low doses of bupe and it was always stronger than higher doses. Before I was clean I went on and off low and high doses of bupe for months at a time and I always got more euphoria from the low doses (the window was 0.2-0.8 mg)

I recently made a new thread about this with details on my theory of what is happening, and another on using naltrexone to block the bupe from attaching just long enough for it to be metabolized into nor-bupe.

http://www.bluelight.ru/vb/threads/597186-Low-Dose-Buprenorphine-Stronger-Opiate-Effects
http://www.bluelight.ru/vb/threads/...-method-for-getting-high-on-nor-buprenorphine.

You opinion is valid, since I cannot prove my theory, but I know what I felt and if it was due to dope sickness it would only feel stronger for the first few doses, it wouldn't persist for months. Also, I had lowered my daily dose to 2mg for a while before trying a 0.8 mg dose, so I wasn't even dopesick the first time it worked for me. I suggest trying this for yourself before forming a opinion, the more people that try this the more information we can get, and figure out what is really going on.
 
I should have named this thread "Orvinols".

Does anybody know, perchance, if the c-ring on the orvinol style morphinan has a name? (The bridge between the 6 & 14 position, with the center bond either single or double bonded, on the cyclohexane ring?)

That's an interesting configuration and I'd be curious to see it on molecules elsewhere for their QSAR with it.
 
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