Brain Supplements & Nootropics mega thread
The following are either antiapoptotic, synaptogenetic, neuroprotective (either directly or allosterically), upregulate endogenous neurotrophic factors, or directly stimulate the production of new neurons from stem cells. (and I'm sure they produce other effects, as well)
nerve growth factor
brain-derived neurotrophic factor
neurotrophin 1/2/3/4
pregnenolone sulfate, dhea
aromatase
estradiol via preg
testosterone
dihydrotestosterone
pheromones
long-term administration of NSAIDs
curcumin (also conduces to apoptosis in cancerous cells)
galanthamine
protein kinase M zeta
cyclic adenosine monophosphate responsive element binding protein (CREB)
cypin & tubulin
T-588
l-acetylcarnitine
l-creatine
l-theanine, egcg (green tea)
fluoxetine (and probably other SSRIs)
sodium valproate
AIT-082/Neotrofin
alcar
almitrine-raubasine
phosphatidylserine
phosphatidylcholine
docosahexaenoic acid (DHA)
weak cb2 receptor agonists
docosahexaenoic acid + cytidine diphosphate choline (citicoline) + uridine 5' monophosphate (UMP)
cytidine diphosphate choline (choline, acetylcholine precursors)
carbenoxolone
nimodipine (NIM)
cysteamine
cerebrolysin
hyperforin
erythropoietin
lithium
Idebenone
dimebolin hydrochloride
growth-associated protein 43 (GAP-43)
ghrelin
GVS-111 / Noopept / DVD-111
rolipram and other phosphodiesterase 4 inhibitors
ampakines (piracetam)
selegiline
rasagiline
hydergine (ergoloids, lsd)
5hta2/2c agonists (decrease bdnf in hippocampal area but raise other areas especially prefrontal cortex, 5hta2 antagonists only decrease bdnf by 30% so the formula is multi-neurotransmissional, hippocampal area is glutamine/dopamine/vasopressin)
desferal
VK-28
ketamine, ghb (most gabaergics decrease like alchohol)
moclobemide
royal jelly
glutathione (alpha lipoic acid- also regulates vit c and e)
vinpocetine
gotu kola
magnolia bark
MW01-5-188WH
nobiltin (citrus)
vitamin e
zinc
exercise
flavoniods, polyphenols, some sterols
omega 3 (modulation)
small dose stimulants
excitory environments (especially activating places where theres are alot of nerves, like the fingers, using opposite hand would increase plasticity between hemispheres, visual cortex, mostly the brain itself, etc)
caloric restriction (Perhaps because of the high levels of ghrelin and low levels of cholecystokinin associated with caloric restriction?, but sugar is good for mitochondria)
so, bdnf is the main culprit for neurogenesis/synaptogenesis, but igf-1 is really the culprit of stem cell differentiation. stem cells run out eventually some earlier than others, but the dendritic connections only decrease when there aren't enough things stimulating, oxidation, other stuff. stem cells could also come in from bone marrow up the spine. of course taking lower level stuff, the body is alot like a computer, is more universal, but also more dangerous. its better to have some only neuroprotective compounds instead of all bdnf stimulation. usually, compounds will have several level feedbacks, specific brain regions and neurotransmissions. more things have some of these features, but they ultimately come out to be negative. gaba increases hgh, but decreases excitation. cannabis and synthetic cannabinoids are excitory and bdnf stimulatory via cb2 receptors, but hippocampal apoptotic, so the effect is more recyclability without memory writing. basil and oregano are cb2 agonists, but marginal in their popular dosage. so there is multiple cases of combinatory effects, and a sense of safe significance so far with these compounds. it should be dependent on what someone had before and what they are going for, some people are acetylcholergenic, math people, while others are more emotionally expressive. taking alot of bdnf compounds would also increase the chances of brain cancer, so it is good to spread out, and only take low doses to optimize content. someone doesn't want to have high neurogenesis at times of content emptiness. everything is dose dependent, and some of them have a point where it reverses. the point of this project is to map out alot of the possible brain nutrients that someone might run in to. there is also a class named "nootropics" which are specifically a group for learning enhancement that don't necessarily directly do these three functions, but definitely do excite. alot of them are in here, one of them is modafinil, it does induce acytlcholergic activity etc, upregulation of these kinds of compounds in general is beneficial, research its contradiactions before taking.
list started from an archive on this site
http://www.bluelight.ru/vb/archive/index.php/t-413261.html, make sure to do research because neuropharmacology is always incomplete especially from the perspective of a person. the rule is that isolated synthetics are stronger, but sometimes plants will be alot stronger. usually plants have less side effects. alot of the time the functions will go out into the close class of compounds, and into their proper endoconversion. something like 5htp on the synapse has different effects than a more complex or foreign molecule, or even a simpler endogenous molecule.
