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Non-irreversable nicotinic agonists?

Nagelfar

Nagelfar

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So what if cigarettes etc replaced nicotine with a (would it be ionic instead of covalent?) nicotinergic receptor agonist of the same profile that didn't agonize its receptor irreversibly? Would it be more addictive in the short term (acutely more liable to abuse) but less in the long term (chronically less prone to habituation)?

Supposedly common "nicotine" most prominently affects the Α4β2 nicotinic receptor.
 
Nagelfar said:
So what if cigarettes etc replaced nicotine with a (would it be ionic instead of covalent?) nicotinergic receptor agonist of the same profile that didn't agonize its receptor irreversibly? Would it be more addictive in the short term (acutely more liable to abuse) but less in the long term (chronically less prone to habituation)?

Supposedly common "nicotine" most prominently affects the Α4β2 nicotinic receptor.
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Nicotine isn't an irreversible agonist.
 
serotonin2A said:
Nicotine isn't an irreversible agonist.
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I thought it was, where do you get that it isn't? (Only widespread drug of abuse that permanently alters the receptor until receptor lifescycle ends)

Is sero right? How come memory serves everything I've read says otherwise? I'll have to look when I have more than 30min comp time left.
 
I think you mean partial vs full agonist. and partial agonsts are used for smoking cessation nicotine is more addictive both short and long term
 
TOBACCO is addictive as hell, but nicotine alone, without the traces of beta-carboline MAOIs such as harmine/harmaline found in tobacco, it just isn't the same, non-reinforcing to me at least, and definitely not addictive, I don't crave pure nicotine at all, but tobacco? god I smoke like a chimney in hades. And I NEED a fag when taking opioids. But if I were to use pure nicotine, it just doesn't hit that sweet spot at all, doing it after dosing opiates.
 
Nagelfar said:
No, I mean irreversible. I'll have to look up when/where I read nicotine interacts in such a way
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The pattern of nicotine use is completely inconsistant with irreversible binding. Irreversible agonists continue to produce effects until the receptor is internalized. If that was the case then you would only need to smoke a cigarette once every few days. Even if the nACh channels eventually closed due to desensitization, it would not be possible for other nicotine molecules to bind to the receptor. So repeated ingestion of nicotine would be impossible, because all the receptors would be depleted.
 
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Yeah, Nicotine is not an irreversible one -they are some out there, if memory serves me right, WIKIPEDIA it man.
 
mike.vick said:
Yeah, Nicotine is not an irreversible one -they are some out there, if memory serves me right, WIKIPEDIA it man.
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I've tried, limited time online; but my assumption was from, I believe, reading up on irreversible agonists for the nicoginic receptor and the article saying no point; nicotine already was one.

Someone mention one I can compare it to, I will with my limited internet time.
 
Nagelfar said:
I've tried, limited time online; but my assumption was from, I believe, reading up on irreversible agonists for the nicoginic receptor and the article saying no point; nicotine already was one.

Someone mention one I can compare it to, I will with my limited internet time.
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Take a look at this reference:
http://pubs.acs.org/doi/pdf/10.1021/bi00242a026

[3H]Nicotine can alkylate nACh receptors in the presence of UV light due to a photochemical reaction. But nicotine binding is normally reversible.
 
Im so confused all I know is the only thing I put in my mouth before food in the morning is chewing tobacco. So my guess is its pretty addicting
 
serotonin2A said:
Take a look at this reference:
http://pubs.acs.org/doi/pdf/10.1021/bi00242a026

[3H]Nicotine can alkylate nACh receptors in the presence of UV light due to a photochemical reaction. But nicotine binding is normally reversible.
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OK, I glanced at it, the receptor's in the presence of ultra-violet light, or the nicotine? This just majorly piques my curiousity about wavelengths (light or otherwise) in conjunction to particulate molecular biology.
 
Nagelfar said:
OK, I glanced at it, the receptor's in the presence of ultra-violet light, or the nicotine? This just majorly piques my curiousity about wavelengths (light or otherwise) in conjunction to particulate molecular biology.
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Nicotine + UV yields a reactive molecule
 
I know sunlight degrades a lot of drug solutions like morphine. Is there a field of study like photochemical chemistry? Anyhow, nicotinic receptor covalent binding agonists of note would be interesting in this thread, I'm still looking for some if nicotine itself doesn't under normal conditions. Can't remember why I'd think that were it not the case, something I read, don't remember it having anything to do with light-reaction.
 
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