negrogesic
Bluelight Crew
"Loperamide is an opioid, a piperidine similar to fentanyl, yet it is not addictive in the traditional sense, as it does not permeate the blood brain barrier. Loperamide is also known as immodium.... "
Isnt that what I said? I said that it does not go through the BBB, which makes it not addictive in the traditional sense.....
Loperamide, which was once a schedule 5 drug, is READILY available OTC at all drug stores under the brandname Immodium. Most places also sell a generic loperamide tablets, which are the same, and both are manufactured in the same factory. Although it doesnt permeate the BBB, it does significantly help with opioid withdrawal.
And its possible if you made loperamide in a polystirex like form (which are tiny plastic particles binded to the drug that help it cross the BBB, it was used with DXM in the brand name "desylem"), and in doing this it may result in a CNS active substance, a potent opioid agonist.
Also p-glycoprotein inhibitors like quinidine, or its fellow optical isomer quinine, has been used in the following pubmed study to make loperamide a poteny CNS active opioid agonist. The last sentance of the following qoute is particularly alluring ("can be reversed by a drug causing P-glycoprotein inhibition, resulting in serious toxic and abuse potential")......
When i read the above, i was quite interested, especially about the "serious toxic and abuse potential". I have used quinine to see if it works, in varying doses, as well as varying doses of loperamide, and though i definately noticed potentiation, there was VERY little CNS activity. But quinidine is a stronger p-glycoprotein inhibitor than quinine, so maybe if i had used quinidine, i would have experienced better results. If we could someone way figure out how to make loperamide cross the blood brainbarrier, we could convert a relatively cheap, legal, easily obtainable OTC medication into a potent opioid. I think the polysterix may be the best solution, or perhaps a stronger p-glycoprotein inhibitor combined with a polisterix verision of loperamide might work. If this did actually materialize and someone figured out the way and it starts circulating as a recreational drug, loperamide would become scheduled once again, or watched like ephedrine/pseudoephedrine.
Isnt that what I said? I said that it does not go through the BBB, which makes it not addictive in the traditional sense.....
Loperamide, which was once a schedule 5 drug, is READILY available OTC at all drug stores under the brandname Immodium. Most places also sell a generic loperamide tablets, which are the same, and both are manufactured in the same factory. Although it doesnt permeate the BBB, it does significantly help with opioid withdrawal.
And its possible if you made loperamide in a polystirex like form (which are tiny plastic particles binded to the drug that help it cross the BBB, it was used with DXM in the brand name "desylem"), and in doing this it may result in a CNS active substance, a potent opioid agonist.
Also p-glycoprotein inhibitors like quinidine, or its fellow optical isomer quinine, has been used in the following pubmed study to make loperamide a poteny CNS active opioid agonist. The last sentance of the following qoute is particularly alluring ("can be reversed by a drug causing P-glycoprotein inhibition, resulting in serious toxic and abuse potential")......
When i read the above, i was quite interested, especially about the "serious toxic and abuse potential". I have used quinine to see if it works, in varying doses, as well as varying doses of loperamide, and though i definately noticed potentiation, there was VERY little CNS activity. But quinidine is a stronger p-glycoprotein inhibitor than quinine, so maybe if i had used quinidine, i would have experienced better results. If we could someone way figure out how to make loperamide cross the blood brainbarrier, we could convert a relatively cheap, legal, easily obtainable OTC medication into a potent opioid. I think the polysterix may be the best solution, or perhaps a stronger p-glycoprotein inhibitor combined with a polisterix verision of loperamide might work. If this did actually materialize and someone figured out the way and it starts circulating as a recreational drug, loperamide would become scheduled once again, or watched like ephedrine/pseudoephedrine.
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