Corazon
Bluelighter
- Joined
- May 20, 2013
- Messages
- 1,373
(Nociceptin or) "N/OFQ is a heptadecapeptide, similar to
endogenous opioid peptides; particularly dynorphin
A and it opposes the analgesic effect of morphine after
intracerebroventricular (icv) injection5. The antiopioid
status of nociceptin is confirmed by the fact
that icv administration of antibody against nociceptin
reverses chronic morphine tolerance by about 50 per
cent in rat."
Anyone on bluelight know the deal here ?
Sounds amazing.
ICV as the ROA does not (they are bypassing the blood brain barrier by injecting into the ventricles of the brain). no thank you.
also have no idea how the body would adapt(long term, besides just reducing tolerance) to having it's nociceptin reduced.
still interesting. Any thoughts ?
nociceptin seems like an alternative contribution to tolerance, besides just the body's regulation of opiate receptors.
endogenous opioid peptides; particularly dynorphin
A and it opposes the analgesic effect of morphine after
intracerebroventricular (icv) injection5. The antiopioid
status of nociceptin is confirmed by the fact
that icv administration of antibody against nociceptin
reverses chronic morphine tolerance by about 50 per
cent in rat."
Anyone on bluelight know the deal here ?
Sounds amazing.
ICV as the ROA does not (they are bypassing the blood brain barrier by injecting into the ventricles of the brain). no thank you.
also have no idea how the body would adapt(long term, besides just reducing tolerance) to having it's nociceptin reduced.
still interesting. Any thoughts ?
nociceptin seems like an alternative contribution to tolerance, besides just the body's regulation of opiate receptors.