no more for me... ( Dilaudid )

[paranoid android]

Yeah I know someone it doesn't work for too. Too bad, it's really effective for me. I have to take a lot though, I take 40mg minimum, today I took 40mg but I am inexplicably not feeling very bad compared to usual. When it was really bad with poppy tea I would take 80mg (40 of the pills). But the restless legs stop entirely, my body even feels kind of heavy, and I get a little eyelid droop. I don't get any euphoria whatsoever, but it makes me feel calm and just very mildly uncomfortable.

Well it stops the diarrhea for me and I'm actually pretty sensitive to the constipating effects of loperamide compared to alot of others on here. 8mg's of loperamide will stop the runs for me for most of the day. I don't know how the hell people take doses like 60mg's or whatever. Id probably need a enema after taking that much. I find loperamide to be more constipating then codeine and that's saying alot.

I find clonidine (i don't know if anyone mentioned that one here) to be kind of the same thing. It's a wonder drug for some people in withdrawals but for me it just stops the rushes of adrenaline i get during withdrawals as well as high blood pressure. Although it does help with the godawful hot and cold flashes that make it impossible to get comfortable and the overall anxiety. It helps some people's restless leg syndrome as well but not mine. However it's worth noting that some people get low blood pressure from withdrawals and as clonidine is a rather potent anti-hypertensive this would be the last thing these people need. Also it interacts with alot of medications especially anything that affects blood pressure and this includes most anti-psychotics as well as opioid's. The Orthostatic hypotension that it causes is a bitch and i nearly fainted a few times by standing up too quick so you have to watch that.

 

[john24]

soon i was banging 54 and sometimes 72mg's of hydromorphone 4 times a day.

Dude, I don't know HOW you got through that withdrawal alive. My withdrawal is basically just from 30 mg's total a day. And everytime I gotta go through it (almost every month) it seems harder and harder each month. Most opiate addicts seem like they can't handle withdrawal even once...I gotta do this crap every MONTH ! I think it's slowly messing with me too....they say opiates are so non-toxic and stuff..but I really feel like long term use destroys something upstairs..(receptors?) little by little. for one, because of the tolerance issues that usually increase over time.

What just helped me the most today? you guys wouldn't believe..but it was "Metoclopram". This I had as an old script for stomach issues...when my stomach felt blocked off, this is perfect for that...and unblocks your stomach. But I didn't understand why I felt so good while taking it as well, until i google'd just now.
"Dopamine-2 Receptor Antagonist"

I never even knew this crap...Honest to god truth, significantly better of an opiate "feeling" high than Loperamide. And you can get it from telling the doc it helps your stomach. Completely chilled me out just now...feelin nice and dreamy at the moment. The only downside? my liver area kinda feels pain-like if I take 20mg or more in 1 setting....which makes me question it's toxicity. Probably much more toxic than opiates i'd figure.

but wow, we need a thread on Metoclopram if there isn't one already?

 

[Xorkoth]

Opiate abuse downregulates your opiate receptors, which means they are less effective (though they will recover fully eventually, it's not brain damage it's just how brains work). And the opiate receptors are responsible for a variety of things, most importantly your natural pain suppression and happy emotions. So long-term abuse of opiates makes it (temporarily) difficult to feel happy, which is why it's so difficult to live through.

That's how tolerance builds to drugs, it's because your receptors downregulate (to try to reach homeostatis, your body is always trying to get back to baseline - so if you're always exposing your receptors to opiates, your body tries to make that state feel like sobriety by downregulating the receptors), and you need more for the same effect.

 

[Xorkoth]

Well it stops the diarrhea for me and I'm actually pretty sensitive to the constipating effects of loperamide compared to alot of others on here. 8mg's of loperamide will stop the runs for me for most of the day. I don't know how the hell people take doses like 60mg's or whatever. Id probably need a enema after taking that much. I find loperamide to be more constipating then codeine and that's saying alot.

When I'm taking loperamide I also take a stool softener and laxative, and it pretty much cancels it out, actually it's just slowed down pretty much like a normal opiate does if you're accustomed to it, which is to say, just a little bit. However taking 60mg is pretty much the same as taking 10mg, it doesn't seem to stop me up more as I take more.

 

[john24]

Opiate abuse downregulates your opiate receptors, which means they are less effective (though they will recover fully eventually, it's not brain damage it's just how brains work). And the opiate receptors are responsible for a variety of things, most importantly your natural pain suppression and happy emotions. So long-term abuse of opiates makes it (temporarily) difficult to feel happy, which is why it's so difficult to live through.

That's how tolerance builds to drugs, it's because your receptors downregulate (to try to reach homeostatis, your body is always trying to get back to baseline - so if you're always exposing your receptors to opiates, your body tries to make that state feel like sobriety by downregulating the receptors), and you need more for the same effect.

good explanation.

I usually start feeling naturally better about 2 weeks after...but that's also around the time I get to fill my prescription. The temptation to fill the script always wins out, and I wonder if it'll happen again in a couple weeks. Gotta fight the power. 8(

 

[paranoid android]

Dude, I don't know HOW you got through that withdrawal alive. My withdrawal is basically just from 30 mg's total a day. And everytime I gotta go through it (almost every month) it seems harder and harder each month. Most opiate addicts seem like they can't handle withdrawal even once...I gotta do this crap every MONTH ! I think it's slowly messing with me too....they say opiates are so non-toxic and stuff..but I really feel like long term use destroys something upstairs..(receptors?) little by little. for one, because of the tolerance issues that usually increase over time.

What just helped me the most today? you guys wouldn't believe..but it was "Metoclopram". This I had as an old script for stomach issues...when my stomach felt blocked off, this is perfect for that...and unblocks your stomach. But I didn't understand why I felt so good while taking it as well, until i google'd just now.
"Dopamine-2 Receptor Antagonist"

I never even knew this crap...Honest to god truth, significantly better of an opiate "feeling" high than Loperamide. And you can get it from telling the doc it helps your stomach. Completely chilled me out just now...feelin nice and dreamy at the moment. The only downside? my liver area kinda feels pain-like if I take 20mg or more in 1 setting....which makes me question it's toxicity. Probably much more toxic than opiates i'd figure.

but wow, we need a thread on Metoclopram if there isn't one already?

Well let's just say it was a rather rough week 8( . I never want to come off that big of a opiate habit ever again cause that was brutal. I had a few goodies to help me through such as a few vials of diazepam as well as alot of codeine and some really strong hash. Everything to calm me down basically.

Metoclopramide was a drug i was prescribed as well to stop nausea and vomiting. It's basically a D2 antagonist and possibly a 5-ht3 antagonist that helps your stomach empty out quicker. I never found it to help opiate withdrawal nausea at all but if it works for you go for it. Just stick to as low a dose as possible and take it for the shortest amount of time you need to as high dose long term use is associated with tardive dyskinesia just like high potency anti-psychotics are. Metoclopramide is a potent D2 antagonist and using it longer then 3 months in a row can cause movement disorders in alot of people.

 

[dhcdavid]

A superb anti-emetic (i.e. to combat nausea and being sick) is Domperidone.

It's OTC in the UK but my GP big brother rates it very highly indeed and says that it would always be his first choice as a front-line anti-emetic.

It works great in opioid withdrawals.