Bupe No effect from 16mg suboxone snorted

[pixies+]

Narcan lasts maybe 2 hours methadone lasts 30 so that answers why this person needed more doses of narcan

If methadone still in your blood stream it does not matter how much you give

This story also doesn’t sound right not saying it’s made up but when this situation occurs you’re supposed to be just be hooked up to a continuous narcan drip not be given dose after dose lol

Yeah I understand that… something wasn’t making sense in my head.. nothing unusual lol

 

[Voxide]

Yeah I understand that… something wasn’t making sense in my head.. nothing unusual lol

It can be a lot to take in for sure
Not that many people know the ins and outs of it. Feel like most people still think Naloxone is the reason for precipitated withdrawal when taking subs too early lol. It doesn’t serve any purpose in there at all other than branding and bowing down to DEA pressure to have it marketed as a schedule III drug instead of II lol

I came from a biochem background originally so it was easier to have it click when laid out the first time

 

[pixies+]

It can be a lot to take in for sure
Not that many people know the ins and outs of it. Feel like most people still think Naloxone is the reason for precipitated withdrawal when taking subs too early lol

I know.. I’ve seen a ton of threads with people asking that question. Although to be fair, I thought the same thing until I got educated about it. That’s how it was explained to me by a doctor. Not sure if it was on purpose to scare me or if he genuinely didn’t know either. I feel the latter. He was passing along info he had been fed.

 

[TombstonePepe]

Given the possible variability of bioavailability of diffrent forms and different roas we have see the mystery. Also we need to look at what if any effect naloxone has in comparison to buepe. Naloxone is touted to have a stronger affinity to bind then other agonists.

Very strong agonists like methadone and bupe can overide the affinity of naloxone.

My Father is an ER dock retired and encountered a methadone suicide attempt that required ALL of the Narcan for multiple hospitals to reverse the methadone OD attempt. She made it, but literally took almost all the narcan from four whole hospitals to push through.


I know the ROA fixation. Is this the reason you are choosing to administer this rout despite negative results?

So I’ve used Suboxone sublingually and nasally. When I use Suboxone (name brand strips) nasally they work a lot quicker and more effectively than sublingually.

When I got my latest refill I was given generic bupe pills. First, I tried taking them the right way (sublingually) and I still felt like shit so I tried them nasally since the Suboxone strips are more effective that way. Well, I felt even worse when I snorted the generic bupe pills. Keep in mind, I was using the same amounts I used with the Suboxone strips.

 

[DeathIndustrial88]

I usually take the name brand Suboxone strips (2mg ones), but when given the 2mg Hikma pills they barely covered me. If I tried to do more I’d feel pretty awful.

I’m genuinely curious if there is more Nalaxone in generics than the name brand. Obviously, if you’re used to taking generics you’ll be fine and won’t notice the difference, but going from Suboxone to generic bupe was a no go for me.

Generics are allowed like a 20% leeway.

With brand name drugs, it must contain 100% of the dose it says on the package. But generics only need to have 80% of said dose, with the rest being inert fillers & flavorings & BS.
So it's possible when you were on the brand name, you were receiving a fuller dose & then once you switched to the generics, you weren't receiving the whole dose that you're use to.

Plus the more subs you take anyway, the more you're just saturating your opioid receptors, so more & more isn't going to help you feel any different. It can actually make you feel worse cause once you've taken enough bupe to totally cover all your receptors, you're basically just using an antagonist & blocking up all your receptors. Plus with the ceiling effect, eventually taking more bupe isn't going to have any added benefit.

I've been on generics for a long time now. And some of them work just fine for me, but a lot of them have really bad inactive ingredients in them. Most generic subs have carcinogenic chemicals in them, along with artificial sweeteners & other crap that's terrible for your health & shouldn't even be in there in the first place. Brand name Suboxone also has the same ingredients, it's just in a strip form. I've looked into the ingredients & basically brand name Subs & all the generics use the exact same shit except for slight variations. It pisses me off.

 

[Voxide]

I've been on generics for a long time now. And some of them work just fine for me, but a lot of them have really bad inactive ingredients in them. Most generic subs have carcinogenic chemicals in them, along with artificial sweeteners & other crap that's terrible for your health & shouldn't even be in there in the first place. Brand name Suboxone also has the same ingredients, it's just in a strip form. I've looked into the ingredients & basically brand name Subs & all the generics use the exact same shit except for slight variations. It pisses me off.

Who are we talkin about here? What manufacture

I get the yellow Alvogen nearly all of the time prob 4 times outta 5. The only other one I’ve seen is the mini Dr. Reddy ones

I don’t notice a dif but I know some people do

 

[DeathIndustrial88]

Who are we talkin about here? What manufacture

I get the yellow Alvogen nearly all of the time prob 4 times outta 5. The only other one I’ve seen is the mini Dr. Reddy ones

I don’t notice a dif but I know some people do

Every manufacturer basically.
From brand name Suboxone strips to Dr. Reddy strips... Same exact active & inactive ingredients.

I've never had the Alvogen strips, but I've had brand name & Dr. Reddy's.
I've also had generic pills like the orange hexagon ones with N8 on them. Same exact inactive ingredients.
Along with the pink hexagonal tablets with an "8" on them. Same ingredients.
The dark orange AN 415 ones.
The orange circular ones that say 970.

All of these ones have acesulfame potassium (artificial sweetener) in them. Along with BHT & some other nasty crap. The only difference between all these generics is how much of the ingredient is in there.

I find the best generic tablets are the peach colored circular ones that say "54 375" on them. These use sucralose instead of acesulfame potassium. And I think these ones don't contain any BHT or the carcinogenic chemicals. So I make sure to stick with these ones. They are Hikma brand.

Honestly I wish it were easy to just get straight generic buprenorphine with none of this extra crap in it.

 

[Them Witches]

^ You are right about generics are allowed up to 20% less active ingredient. However, some companies make their generics about the same strength. I prefer Mallinkrodt generic Oxycodone HCl than any other generic option. I had a few Rx's of Mallinkrodt brand name Roxicodone and I felt a small difference. The cost difference it insane.

The OC Oxycotin brand name was a big hit because it had more active ingredient and was a controlled release that instantly released.

When I was on generic fentanyl patches, I started with the generic Sandoz 100mcg containing 16.4mg per patch. Watson generic 100mcg contained 10mg per patch..wtf man.