NMDA antagonists and Opioid Tolerance

[elstongunn39]

I've heard a lot over the years about NMDA antagonists being able to (among other things) reset stimulant and opioid tolerance and/or prevent tolerance building. I've been chipping with opioids and my tolerance has stayed fairly low but is starting to build. I can find some studies but I can't really interpret them. Can anyone give me a good overview on a) whether this shit works b) how much it works c) how do you do it (e.g. small doses daily, or one big dose, several big doses) d) if it will reset you to an opioid naive tolerance or just lower it slightly Thanks so much for helping a layperson out


also what are the basic mechanisms at play here to understand.. if you give me some leads i will research on my own

 

[WSH]

As far as i know it doesn't "reset" tolerance, it just slows the development of tolerance.

So if you already have tolerance, it doesn't work.

 

[elstongunn39]

well i don't have a huge tolerance, so maybe now is the time to start supplementing with this shit

 

[d1nach]

Supplements wont reset tolerance.

Very high dose (ie impairing ) sodium channel blockades or nmda antagonism can cause a super sensitivity in rats especially to amphetamines via a sensitization of the dopamine receptors due to the important role of both nmda and sodium channels in inducing conditioned place preference memory of novel stimulus learning of association and ventral striatium signaling generally associated with reward.


Sodium channel blockades and nmda antag at low sub anesthesic doses in rats may increase stereotyped behavior by inhibiting inhibitory pathways tha tprevent over activity in the reward pathways (basically what someonr would call being disinhibited or idgaf mode)

Sodium channel blockades and nmda antagonism may increase the sedative and ability for rats to stand on a hot plate before it being too hot.

However what is clear is that high doses. Of nmda antagonism or sodium channel blockades completely blunt the rewarding effects of amphetamine by completely interfering with the excitatory signaling needed to push the reward centers process thefeeling and encode the association and drive future use based on that learning.


It is important here we are not talking about like magnesium or something at gnc some supplements do have some effect but typically via iv or at absurddosing. This is with most strongly pcp and mk801 at doses that would mot be safe or reasonable for humams

 

[d1nach]

*the increased pain tolerance with na channel blockers or nmda antagonists MIGHT be feasible esp in hospitals where high doses of opiates are needed