nmda antagonist Agmatine to potentiate opiates

[CHEESEITT]

there have been several studies on animals using dxm to potentiate opiates up to 40% however when tested on humans the results aren't that good. the reason must studies think is because that rat studies use 20mg a kg which means a person would have to use a over a gram of dxm. however

a studies on rats using Agmatine at 10mg a kg showed potentiate of up to 60% and the important thing in this study is that at 10mg a kg this would be a normal dose for a person.

the study was

Modulation of opioid analgesia by agmatine in

European Journal of Pharmacology 296 (1996) 17-22

 

[CHEESEITT]

found another study with higher doses that show morphine was 200% stronger

 

[BilZ0r]

Oh God. Agmatine. I have to put up with people talking about that shit at conferences, and I have to hear about it here too?

Look at it's structure people. Unless you're gonna inject it into your brain, I'd forget about its amine-y ass.

 

[CHEESEITT]

whats wrong with agamine? the animal studies shows it passes the bbb ?

 

[Hammilton]

just wondering, is this found in human semen too?

 

[BilZ0r]

Yeah, I'll believe it when I see it. You can get phenethylamine into the brain by non-intracortical injection too, but only in doses that no human would put up with.

Agmantine, too polar and too easily metabolised, I bet a $50.

 

[onmyway]

Ok i'm a total newb here. what is it about having an amine that keeps something from crossing the BBB?

 

[fastandbulbous]

For NMDA antagonists to boost opiate pain relief I think the 3-methoxy PCP, 3-methoxy deschloroketamine derivatives would be incredibly useful (personal experience)