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Nitrazepam study... What to make of it?

Pegasus

Pegasus

Ex-Bluelighter
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Aug 15, 2006
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Plasma nitrazepam concentrations after an acute intake and their correlation to sedation and serum growth hormone levels.

Concentrations of nitrazepam in plasma were determined by gas chromatography in healthy volunteers after an acute peroral administration of nitrazepam (5 and 10 mg). Placebo tablets were also used, and an assessement of subjective drug effects was made during each medication. In addition serum growth hormone levels were determined. The peak plasma nitrazepam concentration was achieved at 120 minutes (46.9 +/- 3.2 ng/ml, mean +/- S.E.M.) after 5 mg of nitrazepam and at 180 minutes (82.8 +/- 10.5 ng/ml) after the dose of 10 mg. The half-life of nitrazepam in plasma ranged from 16.5 to 48.3 (mean 28.8) hours. A significant positive correlation was seen between the subjective sedative effects and the magnitude of the peak nitrazepam concentrations in plasma. This drug effect was highly significant when the plasma levels of nitrazepam were rising. The subjective sedative effects were more prominent after 10 mg than after 5 mg dose of nitrazepam. The plasma nitrazepam concentration was not significantly correlated with the subjective sedative effect the next morning, 12 hours after the drug intake. Serum growth hormone levels rose significantly during the study both after 5 mg and 10 mg nitrazepam doses (peak levels 16.3 +/- 4.0 and 12.7 +/- 3.1 ng/ml) and were significantly higher than after placebo administration (3.7 +/- 0.7 ng/ml).
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=331868


So what possible applications does this have (if any)?
 
What exactly is "serum growth hormone", if I may ask? Is that just HGH in the blood?

In any case, I was prescribed Nitrazepam for a while. I didn't notice any difference in my size ;)
 
this is well known for diazepam and may occur with all benzos to some degree, though likely perhaps higher with shorter acting varieties taking pre-bedtime
 
GHB has this effect to. Something to do with GABA receptors in general perhaps?
 
I know all GABAs make me eat klike crazy, but G and nitrazepam are the worst,.
 
Splatt said:
I know all GABAs make me eat klike crazy, but G and nitrazepam are the worst,.
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Tell me about it. I ALWAYS eat when I take Phenibut. It pisses me off. I keep telling myself I won't this time, but I do it anyways. Sooooooo hungry.
 
Elephantitis of the testicles ;). To be honest, I am not sure. Like many hormones that are produced in ever-decreasing concentrations over the course of aging, supplementing probably carries some increased risk of developing certain types of cancer (if one is predisposed).
 
hussness said:
What kind of long-term effects are associated with elevated growth hormone levels in adults?
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the only real negative effect is if you have a cancer present in your body it will grow it more rapidly

also some are susceptible to fluid retention that can cause issues but one will usually see that early and can adjust accordingly
 
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