Nigella seed actives-thymoquinone

[levil]

I manage to locate a litre bottle of the oil by Makana. Think it may be on Amazon. Veering close to source discussion so i'll say no more. It contains both black seed and black cumin so its safe as houses really. I believe Black cumin is what you want. It contains both anyways so you may need to take a little more since a teaspoon would logically contain an equal mix of both oils.

Hi, i'v found this thread yesterday.
i'm searching cure for my sister, she is before biopsy with highly suspected Pancreatic cancer.
you can buy the 1 litre bottle of Makana directly from their [url removed]

N. sativa is actually a very important medicinal herb in the Middle East. The problem is that there are several different plants that carry the name N. sativa, so it can be frustrating. Furthermore, the most commonly available one (that you can get in ethnic food supply stores) is usually the inactive one - what you want is the long, thin black seed, not the small roundish one.

Now, when properly identified, this stuff WORKS! We prepare it by grinding it in honey, that way the volatiles are dissolved. It is then taken orally. But even with that R.O.A., there is a RUSH of wellbeing. It literally stops all the symptoms of the flu. It has analgesic and anxiolytic effects, and given the essential oils' closeness to Propofol, I'd bet it is at least partially GABAergic.

In my subjective experience, I HIGHLY doubt it is cannabinoidergic.

What's more, I have found it to produce some kind of synergy with Ketamine so as to make the experience very euphoric.

I don't recommend baking because the active constituents seem to be volatile.

To my knowledge, I had assumed that Thymol (another propofol lookalike) was responsible for the therapeutic effects. Thanks for pointing out Thymoquinone.

you made me do some phone calls because of that remark
I'v talked with oil factory manager now, he said that they using the common seeds, i think it's the roundish ones,
but he said that they send the oil to laboratory in Germany and it contain Thymoquinone.

 

[crOOk]

Omg fuck me, I was just remembered of my propofol experience in the most recent episode of house (in which two of the main characters abuse said substance :D ). I definitely have to find these seed. I even have 50g Thymol at home in case of a cold (I inhale it in hot water - tiny amounts!!). Shit

edit: wait, makana will make me high? if it's only a tiny fraction as good as propofol was, this is still the shit, even if it would rot my cock away. im in germany too, sounds too good to be true to be honest.

 

[pofacedhoe]

just had some propofol today getting my wisdom teeth out. 15 minutes coming round where i felt higher than on about 400mg of mdma. amazing stuff, so rushy loved up confusing and joyed, i forgot i had an operation i just thought all these people wheeling me about loved me and were my minions of joy like corridors in the the west wing

 

[sekio]

Propofol is only active IV as far as I know, so unless you're willing to make wacky thymol emulsions you're gonna have a hard time getting stoned off of nigella seed extract.

Thymoquinone is just another wacky antioxidant terpene, I expect it has about as much central effect at mu opioid as rhodiola has at MAO (read: nothing except in extraordinarily high concs).

I had a paper on propofol analogs, maybe I can dig it up again. As far as I know they act via GABAa.

 

[pofacedhoe]

well thats how it was administered

 

[crOOk]

just had some propofol today getting my wisdom teeth out. 15 minutes coming round where i felt higher than on about 400mg of mdma. amazing stuff, so rushy loved up confusing and joyed, i forgot i had an operation i just thought all these people wheeling me about loved me and were my minions of joy like corridors in the the west wing

YES MDMA, I was gonna compare the euphoria to that. I felt as slick and smooth as I did on mdma (the only ddrug I've never really abused ) towards other people, but more distanced.

Anyway, the oil is ordered and paid for, I will IM the whole bottle as soon as it arrives.
Seriously though, I know someone with an NMR and he ould analyze the oil for me/us. I should have the package before the end of the week.

 

[crOOk]

i had a paper on propofol analogs, maybe i can dig it up again. As far as i know they act via gabaa.

gief! I've been thinking Thymacetine might share some of the pharmacological activity and is active orally. Phenacetine can be slightly euphoric, but nothing that's blow anybody's socks off.

 

[sekio]

Alkylphenols as Intravenous Anesthetic Agents
Journal of Medicinal Chemistry, 1980, Vol. 23, No. 12

cmpd. 46 - thymol - median hypnotic dose: 30mg/kg ld50: 100 mg/kg in mice
cmpd 25 propofol - hd50: 5-10mg/kg ld50: 50mg/kg in mice, in rabbits "7.5-15 mg/kg: rapid induction, good muscle relaxation, short duration of anesthesia (4-7 min) and rapid recovery. 20 mg/kg: lethal"

This is with the stuff administered IV in Cremophor EL (+ DMSO/ethanol). I.e. the "old evil allergic" propofol formulation.

So I guess it's a lot less safe than propofol, which still isn't really all that safe with a t.i. of 1:10... 1:3 is pretty sharp. As far as i know this is probably why they dodnt trial it in rabbits, or at least didnt report anything (favourable or otherwise)

And if it's ~3-6 times less potent than propofol, you're going to be smelling like a pizzaria for a while.

Acetylation isn't going to do anything but make it more unsafe due to possible uneven enzymatic removal of lots of acetate groups. I think propofol group anesthetics should be left as surgical tools, they shouldn't be abused. GHB, benzos, barbiturates, ketamine & nitrous are all there if you want to experience unconciousness.

 

[crOOk]

Alkylphenols as Intravenous Anesthetic Agents
Journal of Medicinal Chemistry, 1980, Vol. 23, No. 12

cmpd. 46 - thymol - median hypnotic dose: 30mg/kg ld50: 100 mg/kg in mice
cmpd 25 propofol - hd50: 5-10mg/kg ld50: 50mg/kg in mice, in rabbits "7.5-15 mg/kg: rapid induction, good muscle relaxation, short duration of anesthesia (4-7 min) and rapid recovery. 20 mg/kg: lethal"

This is with the stuff administered IV in Cremophor EL (+ DMSO/ethanol). I.e. the "old evil allergic" propofol formulation.

So I guess it's a lot less safe than propofol, which still isn't really all that safe with a t.i. of 1:10... 1:3 is pretty sharp. As far as i know this is probably why they dodnt trial it in rabbits, or at least didnt report anything (favourable or otherwise)

And if it's ~3-6 times less potent than propofol, you're going to be smelling like a pizzaria for a while.

Acetylation isn't going to do anything but make it more unsafe due to possible uneven enzymatic removal of lots of acetate groups. I think propofol group anesthetics should be left as surgical tools, they shouldn't be abused. GHB, benzos, barbiturates, ketamine & nitrous are all there if you want to experience unconciousness.

I really need to lern how to properly navigate pub med databases. The question of Thymol's effects on the CNS came up more than once and I never could come up with anything. Here you are with a study comparing it to Propofol. Good thing I have 50g here. What's even better is that no way in hell I'm gonna inject that poison. If the assumed pain during injection won't force me to kill myself, the respiratory depression will. Any more than 10mg inhaled by sprinkling it into hot water feels really fucking irritating to the lungs. Kinda as if I had inhaled pepper spray.

 

[crOOk]

I just tried 21ml of that cold extracted Nigella Sativa seed oil, manufactured by a company named Makana. I have strong doubts this will have any effects at all, the oil neither has a very strong taste nor odor. Not sure about Thymoquinone itself, but many of the contained compounds should be volatile. I was expecting a really intense smell. So maybe the lack of odor is due to long storage periods or the like and the Thymoquinone is volatile itself or degrades under certain conditions. Just wild speculations, I haven't had much success with commercially prepared plant matter/plant extracts before.

well after reading a brazilian study (http://www.scielo.br/scielo.php?pid=S0102-695X2011000300012&script=sci_arttext) I'm quite convinced that even if there will be any form of sedation as reported with the untreated seeds, it wont be due to gabaergic mechanisms. they are using various para-benzoquinones at 80mg/kg...


edit: I slept really fucking well which is remarkable. I had some lack of sleep though, so I will have to keep observing this. Maybe this could serve as a sleep aid. I usually use a little cannabis every night, but sometimes I'm still having trouble sleeping. The other day I took 22.5mg Midazolam rectally right before bedtime and couldn't even sleep for an hour straight. With no benzo tolerance that is, I've always hated them.

 

[asecin]

Propofol is only active IV as far as I know, so unless you're willing to make wacky thymol emulsions you're gonna have a hard time getting stoned off of nigella seed extract.

Thymoquinone is just another wacky antioxidant terpene, I expect it has about as much central effect at mu opioid as rhodiola has at MAO (read: nothing except in extraordinarily high concs).

I had a paper on propofol analogs, maybe I can dig it up again. As far as I know they act via GABAa.

what did you mean by "wacky antioxidant" ? you mean, some silly advertised good for you compound that has absolutely no positive effect at all on anything in reality ? same question with rhodiola, is it a scam ??

 

[sekio]

I mean that it acts as an antioxidahnt in cellular cultures but not at levels that would be normally achieved after ingestion of it by humans.

Rhodiola is supposedly marketed as a MAO inhiitor but even pure rosiridin is something like 1000-10000x less potent than segligine ... nowhere near the same dose in supplements.

 

[asecin]

yeh exactly. i agree with you 100% sekio. so many supposedly beneficial antioxidants found in fruits and vegetables are only beneficial when based in cellular cultures and i dunno why people always claim they are good for consumption considering you need tons of them and still !, very few are able to achieve anything by ingestion. so sad and so much scam out there about eating your fruits and vegetables. wish more educated people spread the word how "antioxidant" is a bullshit term and that nothing will ever save your genes from their programmed destruction.