Mr Blonde
Bluelighter
I was reading about some interesting syntheses, and nicotinamide came up. I was reading the Wikipedia article, and apparently in animal studies it has anxiolytic effects and is theorized to work in a similar way to benzodiazepines.
I can't access the full PubMed article, but they say that it could possibly be an endogenous ligand for the benzodiazepine receptor.
Has anyone ever used nicotinamide by itself? Niacin is metabolized to it, and is purportedly good for bad trips, but niacin causes flushing and itching which nicotinamide apparently doesn't. Apparently can be hepatotoxic at doses above 3 grams though.
I can't access the full PubMed article, but they say that it could possibly be an endogenous ligand for the benzodiazepine receptor.
Has anyone ever used nicotinamide by itself? Niacin is metabolized to it, and is purportedly good for bad trips, but niacin causes flushing and itching which nicotinamide apparently doesn't. Apparently can be hepatotoxic at doses above 3 grams though.
