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Bluelight Crew
Where are the ads on Amphetamine Damage?
Most of us should know methamphetamine is a neurotoxin, whereby continual use over many years results in neural changes which in some cases remain after usage is ceased, but how many know or are informed of the long term neural changes that occur with amphetamine?
This change, as noted in the following publication, does not occur with MDMA or meth, but it is significant enough to warrant further reseach and perhaps a rethink on the safety of amphetmaine. While it's not concluded what long term outcomes are, it's well known that particular Beta amyloid peptides are integral in causing Alzheimers Disease.
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Most of us should know methamphetamine is a neurotoxin, whereby continual use over many years results in neural changes which in some cases remain after usage is ceased, but how many know or are informed of the long term neural changes that occur with amphetamine?
This change, as noted in the following publication, does not occur with MDMA or meth, but it is significant enough to warrant further reseach and perhaps a rethink on the safety of amphetmaine. While it's not concluded what long term outcomes are, it's well known that particular Beta amyloid peptides are integral in causing Alzheimers Disease.
Amphetamine effects on brain protein structure and oxidative stress as revealed by FTIR microspectroscopy
A. Rodríguez-Casado 1, I. Alvarez 2, A. Toledano 2, E. de Miguel 3, P. Carmona 1 *
Abstract
Amphetamines are psychostimulants abused by man, that eventually leads to drug dependence. Amphetamine administration to rodents has been shown to provoke significant neurotoxicity involving dopaminergic nerve terminal degeneration. However, little information related to the effect of amphetamines on reactive oxygen species (ROS) production and neurotoxicity in brain is currently available. Herein we report the biochemical alterations of lipids and proteins in brain sections from amphetamine-treated rodents using infrared microspectroscopy, immunohistochemistry, and immunoblotting. The spectroscopic changes reveal for the first time the formation of -sheet-rich proteins in the cortex, but no significant protein alterations are visible in hippocampus region where hydroperoxide concentration is found to be lower relative to cortex. These result suggest that ROS generated by amphetamine-mediated oxidative stress induce formation -sheet-rich proteins which can be of amyloid -like character. © 2007 Wiley Periodicals, Inc. Biopolymers 86: 437-446, 2007
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