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New study reveals best dosage for ADHD medications

placebonaut

placebonaut

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New study reveals best dosage for ADHD medications

New study reveals best dosage for ADHD medications
www.southampton.ac.uk www.southampton.ac.uk

Researchers have identified the best dosage for each ADHD medication using data from thousands of people with the condition.

A new study published today [14 May] in the Lancet Psychiatry provides the most comprehensive view of dosage effects for five commonly used medications for ADHD.

To help patients and clinicians choose the right dosage, the international research team led by Professor Samuele Cortese from the University of Southampton has also developed a free online tool based on the findings.
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With any medication it's worth asking: "what are we actually treating?"
This is particularly relevant since ADHD is a catch-all term for symptoms of diverse origin implying multiple distinct causes.

This paper identifies notable issues regarding ADHD diagnosis:
ADHD is listed in DSM-5 under “Neurodevelopmental Disorders” in spite of reviews showing that (a) genetic evidence on ADHD is inadequate and diffused with ambiguous interpretations, (b) that no biological marker is diagnostic for ADHD something that even DSM-5 authors themselves explicitly admit, (c) the so-called “underlying mechanisms” remain unknown, and (d) no biological tests are available for its diagnosis.

Moreover, DSM-5 authors implicitly acknowledge that the classification of ADHD as neurodevelopmental disorder is not well-founded: “[O]n the basis of patterns of symptoms, comorbidity, and shared risk factors, attention-deficit/hyperactivity disorder (ADHD) was placed with neurodevelopmental disorders, but the same data also supported strong arguments to place ADHD within disruptive, impulse-control, and conduct disorders”.
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In other words, there is no scientific evidence to support the claim that ADHD is as a condition within an individual—something individuals have, owing to which they are vulnerable to various risks the condition exposes them to. Asserting that ADHD is a neurodevelopmental disorder is a scientific conceit on one hand and reflects the DSM's political, cultural, and financial role in the psychiatrization of children's everyday lives on the other.
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This researcher exposes $14.2 million in undisclosed industry compensation paid to DSM authors. The researcher elaborated on the findings here.

This paper elucidates some perceptual issues:
It is essential that discourse communities do not repeat these four ways of reifying behavior and social relations into an alleged entity with the acronym ADHD. The errors and habits of writing may be epistemologically violent by influencing how laypeople and professionals see children and ultimately how children may come to see themselves in a negative way. Beyond that, if the institutional world shaped to help children is based on misguided assumptions, it may cause them harm and help perpetuate the misguided narrative.
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I wasn't aware I had ADHD until much later as an adult. I wish doctors and psychiatrist I sought treatment from had recognized ADHD symptoms in me sooner instead of increasing and adding new psych meds associated with mood disorder.
 
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If you're talking about pharmaceutical price gouging and advertisement associated with how a person feels mentally or physically people including doctors spare no defense in keeping the customer happy and coming back for more. What may have been an honorable desire to help people has turned into a profitable venture of making big bucks reliving pain and discomfort.

By nature, humans will avoid discomfort by taking the easy way out instead of directly dealing with the issues at hand. For the most part we have become weak and dependent on quick fixes that cost us way more than enduring a little, we pay in the long run.
 
M!$TER-ED said:
If you're talking about pharmaceutical price gouging and advertisement associated with how a person feels mentally or physically people including doctors spare no defense in keeping the customer happy and coming back for more. What may have been an honorable desire to help people has turned into a profitable venture of making big bucks reliving pain and discomfort.
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I get this as a US view, think the UK market is very different though, we generally try to avoid prescribing things due to the cost and way things are funded.
 
You have to remember that ADHD medications are not supposed to give you a euphoria, even given their similarity to street stimulants; amphetamine salts and methylphenidate at prescribed dosages produce effects in an individual with ADHD compared to a low dosage of a sedative and the reason why their favorable is not necessarily due to their attention-fixing qualities but their corrective functions in producing an effect where the individual isn't trying to achieve a short-term overall plan of action in their lives but succeeds in producing long-term action to affect in the presents of reward and consequence, and can more effectively plan out their future goals.

The exact function of this is Amphetamine and Methylphenidates ability to a corrective procedure on an individuals Caudate Nucleus and Amygdala where they're communicating more correctly. The studies show that the stimulants cause a suppression of the amygdala by the caudate nucleus when responding to short-term and long-term action of reward presences so when an individual is presented with a reward-consequence their caudate nucleus will suppress the amygdala and the amygdala when suppress the prefrontal cortex or the front lobe in general and will buy them time to think about their actions so they don't make a social consequence error.

That's why with stimulants they see peer relationships become more positive towards the individual and correct obnoxious behavior and immediate-fix (causing in short-term relationship to) action-consequence where instead they see the long-term positive rewards and they aim for them naturally as an individual again
 
They'res also a relationship here to ODD (oppositional defiance disorder) you can talk about and they believe it might be comorbid with ADHD but that's understudied at this point.
 
"The will to label will always prevail over what's being labeled, usually at the expense of either truth or understanding."
-BR

In the UK we stopped trusting the DSM when it became apparent that in essence the editors were being bribed to invent new classicifcations so SELL MORE MEDICINES.

So we still use the DSM 3B.

It's also important to read the equivelents of the DSM used in other cultures. That should tell you that a lot of behaviorial disorders are bound to culture, politics and that NEED to label.

If you overwhelm people with information, don't be surprised if they struggle to focus on the mundane.

Nobody falls neatly into one box and so we have cluster A and cluster B disorders which broadly fall into behaviors that are damaging the person and those that are damaging to society. A very odd way of defining clusters in my opinion.
 
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