New RC suggestions UK (etazolate, RC barbiturate Benzonoylbarbital and Diproqualone)

[swimming.since.99]

In fear of a possible RC benzo ban or a ban on the entire benzodiazepine family, I decided to make a list of chemicals that are superior to benzos and are completely legal, let me know what you think guys.

Etazolate, Cartazolate, Tracazolate. - These are Pyrazolopyridine derivatives, anxiolytics that bind at the barbiturate site of the GABA-A receptor, they are also Adenosine A1 and A2 antagonists. This gets rid of any sedation issues and increases concentration. I think these are great specifically for anxiety relief, and people that need to function in everyday life without feeling side-effects such as amnesia and sedation.

Benzonoylbarbital (Benzonal) - A long-acting barbiturate, with an 80h half-life, general effects are identical to Phenobarbital, however benzonoylbarbital causes less sedation and is completely legal, since it doesn't even fall under the barbituric analogue laws.

Diproqualone - Similar to Methaqualone in every way, but is rumored to be less sedative and more potent, with a slightly longer half-life, making it superior to Etaqualone.

 

[fractiousrabbit]

I hate to point this out Swimming, but your near death a week ago (respiratory arrest only stopped by paramedics) is pretty much why there is a race to make all these chemicals illegal. Same might be said of tighter restrictions on opioids etc. When you overdose again, if the medics fail to arrive in time, your parents will undoubtedly lobby the government for "Swimmings Law" and tighten legislation even further. Why do people insist on ruining it for the whole class?

 

[Burnt Offerings]

Benzodiazepines will never be made illegal. They're very useful, safe and versatile drugs, and the ratio of people who abuse them vs. people who take them therapeutically is large. Plus they are still very commonly prescribed and a lot of money is made off them.

 

[Burnt Offerings]

I can't really even think of what drug would possibly replace benzodiazepines for its indications...there was a time period in which benzodiazepines competed in the marketplace with meprobamate, methaquaalone and even barbiturates but those days are long gone.

 

[swimming.since.99]

I hate to point this out Swimming, but your near death a week ago (respiratory arrest only stopped by paramedics) is pretty much why there is a race to make all these chemicals illegal. Same might be said of tighter restrictions on opioids etc. When you overdose again, if the medics fail to arrive in time, your parents will undoubtedly lobby the government for "Swimmings Law" and tighten legislation even further. Why do people insist on ruining it for the whole class?

Sure, you're right. But I would hate to point out that this has nothing to do with my post above.

I can't really even think of what drug would possibly replace benzodiazepines for its indications...there was a time period in which benzodiazepines competed in the marketplace with meprobamate, methaquaalone and even barbiturates but those days are long gone.

Well, I just pointed out Etazolate and it's analogues, they are far superior to benzodiazepines considering that they bind to the barbiturate receptor and they cause minimal sedation due to the adenosine antagonism, however they are much safer than barbiturates due to their high selectivity, by that I mean barbiturates affect many, many recptors throughout your brain, they modulate AND agonise GABA-A receptors (while benzos only modulate GABA-A), they also antagonise Kainate, AMPA and nAch receptors, 3/4 vital excitatory receptors, which in larger doses leads to coma, respiratory and cardiac arrest, which makes them just as dangerous, or perhaps more dangerous than opiates, since there's no antidote to barbs, so in this perspective, benzos are safer, but that's their only advantage.

 

[blowpipe]

Sure, you're right. But I would hate to point out that this has nothing to do with my post above.

Well, I just pointed out Etazolate and it's analogues, they are far superior to benzodiazepines considering that they bind to the barbiturate receptor and they cause minimal sedation due to the adenosine antagonism, however they are much safer than barbiturates due to their high selectivity, by that I mean barbiturates affect many, many recptors throughout your brain, they modulate AND agonise GABA-A receptors (while benzos only modulate GABA-A), they also antagonise Kainate, AMPA and nAch receptors, 3/4 vital excitatory receptors, which in larger doses leads to coma, respiratory and cardiac arrest, which makes them just as dangerous, or perhaps more dangerous than opiates, since there's no antidote to barbs, so in this perspective, benzos are safer, but that's their only advantage.

As far as I understand, the reason benzos are way more safe in overdose is that they only modulate the GABA-A receptor, but don't affect the Cl- traffic; GABA does that, and in case of increased GABA-A activity, the body decreases the amount of GABA produced. Barbs, on the other hand not only modulate GABA-A, but also affect the Cl- influx, thereby making the decrease in GABA production close to pointless in case of OD, making them a lot more dangerous. So the fact that a drug binds to the barbiturate allosteric site is far from being better than the BZD site.

Unless you can produce studies that back up your claim, I'm going to agree with Burnt and say that benzos are the go-to when it comes to GABA agonism/modulation. Also, claiming that etazolate et al are far superior to benzos is very far fetched and sounds ridiculous; maybe they are good, or even better, but far better? We must be dealing with a miracle drug here then.

 

[jammin83]

RC barbituates??? Oh lord, help us all.