I loved 4-methoxyphencyclidine...but the 3-methoxy isomer is just iffy shit.
It seems to be a convulsant, at least, it has triggered multiple episodes of myoclonic seizure in me.
Put me in hospital several times. Very steep dose-response curve. A few tends of mg over the line, and it fucked me up in a bad way. With MXE or 4-methoxy-PCP I didn't even have to bother measuring the dose on a scale (not that I advise that to anyone), I just used the tip of the blade of one of my daggers to measure a decent sized bump into the vial of saline used to prep my shots, and was fine.
3-OH-PCP seemed a lot more forgiving.
I have intermittent issues with (what I believe to be) myoclonic seizures, which have been triggered in turn by MDMA (and other stims), Ketamine, MXE and benzo withdrawals in the past, but oddly I never experienced an unusual amount of them on 3-MeO, and I took a lot of it. Sometimes a constant medium dose for a couple of weeks, sometimes large doses, several of which landed me in 'intervention' situations and once in hospital. I came round from the longest and deepest hole of my drug-taking life to realise that my housemates had called the paramedics. Despite the fact that I was sober enough to say "I'm really sorry to waste your time, lads, but I'm fine, I just holed..." I was still quite clearly a bit baffled about why there were a lot of bright-vested green-costumed official looking people in my bedroom, so they essentially forced me under the 'duty of care' to go with them. I understand why they did, but being basically sober at this point, being forced against my will into an ambulance, strapped down to a bed and threatened with police intervention unless I consented to blood and urine tests & an ECG, and then wait for 8 hours with nothing but my guilty thoughts about taking up valuable hospital bed space and resources (and, of course, worrying my loved ones)... well, it all seemed a little unnecessary!
I can't even say that I gained anything profound from it, because 3-MeO causes a comprehensive amnesia in me for the entire hole, with no memory of anything even getting 'a bit weird' leading up to it. Just 'one minute I was in bed, the next minute I was in my chair with loads of people urgently asking me how much I'd taken.'
It's a truly astounding drug with a great deal of therapeutic benefit and an overall experience that I can't really compare. But it's very easy to get wrong.
Back on topic, I had a chance to try Diphenidine recently too, and the first trial has led me to believe that it has potential value to dissociative 'connoisseurs' (I don't mean to sound pompous, but hopefully you know what I mean...) But can't yet work out if it will appeal to more casual Ketamine/MXE fans.