I find that as life becomes more fulfilled in other ways, the use of dissociatives for that enforced 'escape and zen' state becomes both less attractive and less practical. If you're in a relationship, or when your social life is particularly active, or when the work life is good it starts to negatively impact interaction with the world. They're tricky to let go of but the less lonely and more confident I feel, the more I want to reduce their participance in my life. Though that becomes ironic, because when I do feel alone and helpless turn to disso's for relief, they create more 'distance' between the self and the things around us that we wish to connect with, and it becomes harder to reconcile that feeling with other fulfilling things...
On the other hand, I echo the others here that have said that sometimes, dissos like MXE and 3-MeO can be a catalyst for productivity, motivation and positivity. Unfortunately I find it too nearly impossible not to binge, and since indulgence is sometimes inevitable, I have to limit myself to only buying small-ish amounts with a couple of clear days in the knowledge that once I've got it, it's disappearing fast. Its therapeutic potential is destroyed by this behaviour, and it's people like me that ruin that potential for everyone!
). You kinda need to get to know each batch and work out your sweetspot anew each time.
