New Opana ER oral availability and conversion questions

[JanusMagus]

First, I've been looking for other topics for hours, but nothing seems to address exactly the questions I am wondering about.

Want to figure out if it's worth it for anyone to take the new ER Opana orally, given the difficulty and uncertainty involved with insufflation. My main concern and why I can't just figure this out myself is that I'm unsure that snorting the old ER opana broke the time release or not (and also less importantly, whether breaking up the new ER opana into little pieces and swallowing those breaks it a little bit at least, kind of like it does with OP Oxycontin). Also, I'm unsure if breaking the ER opana's into smaller pieces keeps the bioavailibility at 10% still.

Let's say snorting 5mg of the old opana ER was great for you. If time release questions aren't an issue, then just taking 20mg of the new opana ER orally shouldn't be an issue because with a conversion rate of 10% versus 40%, the amount should end up the same.

So, my two (or 3) main concerns/questions are: how much time release is broken with snorting the old ER? If it isn't broken, taking 20mg new ER orally should be the same as 5mg snorted as long as breaking up the newer ER doesn't break any time release at all.
If some time release is broken snorting, then is it an absolute waste to swallow 20mg versus snorting 5mg (since you'd then be getting that 5mg quicker versus 20mg over a longer time and hence less at once)?
Finally, does bioavailibility stay at 10% orally no matter what you do to the pill?

 

[Swimmingdancer]

We aren't here to help you get high, but I will try to answer your specific questions.

The average oral BA of oxymorphone is 10%, that is not specific to Opana ER and doesn't matter what you do to the pill, so there is no way to increase the oral BA other than taking it with something that makes more of it absorb or decreases the amount of the drug inactivated by your gut/liver. The time-release matrix just makes the drug absorb more slowly over a period of time, it isn't responsible for oxymorphone's low oral BA. The thing about bioavailability is that it isn't set in stone and it varies from person to person (and can be affected by many factors), the listed BAs are just averages from the people they studied. So just because you could take 5mg nasally doesn't mean you should take 20mg orally.

Bioavailability is how much of a drug reaches systemic circulation in your bloodstream, it does not measure how quickly a drug is absorbed. So the BA of oral oxymorphone should be about the same whether it's ER or not. Defeating the time release shouldn't change the BA, it will just make the drug absorb faster. When snorting oxymorphone the drug absorbs faster, provided you are either not taking an ER version, you've been able to defeat the time release, or the time-release doesn't make it difficult to absorb nasally. I'm not sure whether the time-release prevents it from being absorbed properly when snorted. Another reason to not assume 20mg orally will be safe just because you were able to take 5mg nasally. Wikipedia does list snorting as a "successful means of Opana ER misuse", but does not provide details. I wonder if anyone knows whether it's safe to be putting the inactive ingredients up your nose?

I would say the safest and most predictable way to take it is as intended, orally. If you are going to snort them or crush them and eat them please be careful and start with a low dose.

 

[JanusMagus]

Thanks for the reply. I'm just looking to get effective pain relief while avoiding effects such as nodding off.
Definitely going to start off low, especially because it's definitely a possibility that the ER wasn't totally effective intranasally, so that I could have been getting less than 100% of the oxymorphone or at least not breaking the time release 100%.
The only thing is, I also don't want to waste. If it does nothing after an hour I suppose then I know to take a little more?

edit: This thread seems to come close to answering what I was wondering: http://www.bluelight.ru/vb/threads/...-the-new-Opana-ER?highlight=taking+opana+oral
They make it sound like even taking 20mg vs 5mg may not work.

 

[JanusMagus]

update: what the thread I linked to suggested about taking 20mg of the new ER orally seems to be correct.
5mg crushed and snorted of the old ER worked much better than 20mg of the new taken orally, and I suppose it's because while the bio-available amount should then be about equal, crushing and snorting actually must have broken the time release a good deal so I'm getting that same amount over 8 hours now versus much quicker.