It would be very interesting - but perhaps hard to get across an ethical committee - to consume 5-MeO-DMT while co-administering one of those selective 5-HT1A antagonists. It is quite possible that the colourful rich visual experience (and nature!) of DMT returns to the 5-MeO-DMT realm then.
Suppression of 5-HT2A-mediated HTRs by 5-HT1A only occurred after high 5-MeO-DMT doses, suggesting involvement of other receptors in modulating psychedelic-like effects. Overall, our findings provide key information about the receptor target profiles for 5-MeO-DMT analogs, the structure-activity relationships for inducing psychedelic-like effects, and the critical role of 5-HT1A agonism in modulating acute psychoactive effects of 5-HT2A agonists.
