trilogy_zero
Greenlighter
- Joined
- Jan 6, 2011
- Messages
- 8
Legal phycoactive highs
by ike p
Legal pyhcoactives are readly availible and easy to obtain
Research of pyhcoactive drugs and receptor affinity in our brains
THIS IS FOR RESEARCH PURPOSE ONLY
LETS get started I will be explaining many phycoactive herbs and cemicals
STIMULANTS also called psychostimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion release of these catecholamines from storage vesicles in cells. Amphetamines are known to cause elevated mood and euphoria so they can be addictive.
Propylhexedrine: (Benzedrex, Dristan, Obesin) is a stimulant drug related to methamphetamine Propylhexedrine is structurally similar to methamphetamine. The only difference in the two compounds is that an alicyclic cyclohexyl group is used in lieu of the aromatic phenyl group of methamphetamine. It is because of this that propylhexedrine is not an amphetamine, nor even a phenethylamine, but instead can be referred to as a cycloalkylamine produces similar effects to amphetamine, methamphetamine
Cyclopentamine is the cyclopentane homologue of propylhexedrine Cyclopentamine acts as a releasing agent of the catecholamine neurotransmitters norepinephrine (noradrenaline), epinephrine (adrenaline), and dopamine When ingested orally in sufficient quantities, cyclopentamine produces similar effects to amphetamine, methamphetamine
Methylhexaneamine methylhexaneamine or 1,3-dimethylamylamine is a stimulant dietary supplement found at natrual food stores as it is a component of the oil from Pelargonium graveolens produces similar effects to amphetamine
Levomethamphetamine is the levorotary (R-isomer) of methamphetamine and active ingredient used in some over-the-counter nasal decongestants including Vicks Vapor Inhaler produces similar effects to amphetamine, methamphetamine
Yohimbine is an alkaloid with stimulant and aphrodisiac effects found naturally in Pausinystalia yohimbe it binds to so many receptors that it could be classify as a dirty drug having many effects Yohimbine has high affinity for the α2-adrenergic receptor, moderate affinity for the α1-adrenergic, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.[13][14] It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2, and as a partial agonist at 5-HT1A.[13][15][16][17] Its intrinsic activities at the other sites listed are unclear/unknown but it is probably mostly antagonistic at them.
Caffeine Caffeine is the world's most widely used psychoactive drug and by far the most common stimulant. The vast majority (over 85%) of people in the United States consume caffeine on a daily basis caffeine can be habbit forming
Ephedrine is similar in structure to the (semi-synthetic) derivatives amphetamine and methamphetamine. Chemically, it is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). It works mainly by increasing the activity of noradrenaline on adrenergic receptors produces similar effects to amphetamine, methamphetamine
Pseudoephedrine is a diastereomer of ephedrine Pseudoephedrine is a sympathomimetic amine and precursor of methamphetamine and methcathinone which are Controlled Drugs and Substances
Nicotine is the active chemical constituent in tobacco Nicotine is used widely throughout the world for its stimulating effects acts on the nicotinic acetylcholine receptors
sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement sedatives can cause euphoria and can be habbit forming
Alcohol affects the gamma-aminobutyric acid (GABA) receptors, to produce a depressant (neurochemical inhibitory) effect. Alcohol is similar to other sedative-hypnotics such as barbiturates and benzodiazepines both in its effect on the GABAA receptor although its pharmacological profile is not identical.
Kava (Piper methysticum) Is a herb The onset of a moderate potency kava drink is 20–30 minutes, with effects usually lasting for two hours but effects can be felt up to eight hours after ingestion kavalactones potentiate GABAA activity. extracts are best
Skull cap is a herb found easy like kava A number of the flavones found in S. lateriflora extracts have been reported to selectively bind with high affinity to central GABAa benzodiazepine receptor sites
Valerenic acid is from valerian root herb extracts has been demonstrated to be both a subtype-selective GABAA agonist
Beta-phenyl-gamma-aminobutyric acid better known as Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter Gamma- amino-butyric-acid The addition of a phenyl ring allows Phenibut to cross the blood brain Although the calming action is similar to other GABA agonists it acts on GABAb receptor.
Theanine only has weak affinity for the glutamate receptor on post-synaptic cells. Rather, its primary effect seems to increase the overall level of the brain inhibitory transmitter GABA
Antihistamines Are sedative but dont produce high amounts of euphoria
Melatonin is also a sedative but not that euphoric
Diethyl ether acts on GABA
gamma-Amino-beta-hydroxybutyric acid (GABOB), also known as gamibetal or buxamin, is a derivative of the neurotransmitter GABA the effects are GHB like its a dieatary supplement found on the net.
opiate/opioid describes any of the narcotic opioid alkaloids opioid receptor agonist – its main effect is binding to and activating the μ-opioid receptors in the central nervous system
Sinomenine or Cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum Sinomenine is a morphinan derivative, related to opioids such as levorphanol
Kratom primary pharmacology is mediated by the alkaloids 7-hydroxymitragynine and mitragynine
Picralima nitida alkaloids- akuammidine and -akuammigine, were found to be potent μ-opioid agonists
The Calabar bean is the seed of a leguminous plant Eseroline is a drug which acts as an opioid agonist It is a metabolite of the acetylcholinesterase inhibitor physostigmine
Salvia divinorum salvinorin A is a potent and selective κ-Opioid (kappa-Opioid) receptor agonist By mass, salvinorin A "is the most potent naturally occurring hallucinogen
Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors when taken with Prilosec Omeprazole above 30 mg produces typical opiate effects.
Poppy seed tea contains codeine morphine thebain
Protopine is a benzylisoquinoline alkaloid occurring in Argemone mexicana and corydalis tubers and other plants of the family papaveraceae. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an opioid analgesic
psychedelic A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception
Elemi oil Canarium luzonicum Ensure room is well ventilated when using Elemi Oil and do not ingest as misuse can lead to psychedelic experiances similar to a cross between mescaline and LSD
Morning glory contains lsa look it up many plants contain it
dextromethorphan look it up
by ike p
Legal pyhcoactives are readly availible and easy to obtain
Research of pyhcoactive drugs and receptor affinity in our brains
THIS IS FOR RESEARCH PURPOSE ONLY
LETS get started I will be explaining many phycoactive herbs and cemicals
STIMULANTS also called psychostimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion release of these catecholamines from storage vesicles in cells. Amphetamines are known to cause elevated mood and euphoria so they can be addictive.
Propylhexedrine: (Benzedrex, Dristan, Obesin) is a stimulant drug related to methamphetamine Propylhexedrine is structurally similar to methamphetamine. The only difference in the two compounds is that an alicyclic cyclohexyl group is used in lieu of the aromatic phenyl group of methamphetamine. It is because of this that propylhexedrine is not an amphetamine, nor even a phenethylamine, but instead can be referred to as a cycloalkylamine produces similar effects to amphetamine, methamphetamine
Cyclopentamine is the cyclopentane homologue of propylhexedrine Cyclopentamine acts as a releasing agent of the catecholamine neurotransmitters norepinephrine (noradrenaline), epinephrine (adrenaline), and dopamine When ingested orally in sufficient quantities, cyclopentamine produces similar effects to amphetamine, methamphetamine
Methylhexaneamine methylhexaneamine or 1,3-dimethylamylamine is a stimulant dietary supplement found at natrual food stores as it is a component of the oil from Pelargonium graveolens produces similar effects to amphetamine
Levomethamphetamine is the levorotary (R-isomer) of methamphetamine and active ingredient used in some over-the-counter nasal decongestants including Vicks Vapor Inhaler produces similar effects to amphetamine, methamphetamine
Yohimbine is an alkaloid with stimulant and aphrodisiac effects found naturally in Pausinystalia yohimbe it binds to so many receptors that it could be classify as a dirty drug having many effects Yohimbine has high affinity for the α2-adrenergic receptor, moderate affinity for the α1-adrenergic, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.[13][14] It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2, and as a partial agonist at 5-HT1A.[13][15][16][17] Its intrinsic activities at the other sites listed are unclear/unknown but it is probably mostly antagonistic at them.
Caffeine Caffeine is the world's most widely used psychoactive drug and by far the most common stimulant. The vast majority (over 85%) of people in the United States consume caffeine on a daily basis caffeine can be habbit forming
Ephedrine is similar in structure to the (semi-synthetic) derivatives amphetamine and methamphetamine. Chemically, it is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). It works mainly by increasing the activity of noradrenaline on adrenergic receptors produces similar effects to amphetamine, methamphetamine
Pseudoephedrine is a diastereomer of ephedrine Pseudoephedrine is a sympathomimetic amine and precursor of methamphetamine and methcathinone which are Controlled Drugs and Substances
Nicotine is the active chemical constituent in tobacco Nicotine is used widely throughout the world for its stimulating effects acts on the nicotinic acetylcholine receptors
sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement sedatives can cause euphoria and can be habbit forming
Alcohol affects the gamma-aminobutyric acid (GABA) receptors, to produce a depressant (neurochemical inhibitory) effect. Alcohol is similar to other sedative-hypnotics such as barbiturates and benzodiazepines both in its effect on the GABAA receptor although its pharmacological profile is not identical.
Kava (Piper methysticum) Is a herb The onset of a moderate potency kava drink is 20–30 minutes, with effects usually lasting for two hours but effects can be felt up to eight hours after ingestion kavalactones potentiate GABAA activity. extracts are best
Skull cap is a herb found easy like kava A number of the flavones found in S. lateriflora extracts have been reported to selectively bind with high affinity to central GABAa benzodiazepine receptor sites
Valerenic acid is from valerian root herb extracts has been demonstrated to be both a subtype-selective GABAA agonist
Beta-phenyl-gamma-aminobutyric acid better known as Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter Gamma- amino-butyric-acid The addition of a phenyl ring allows Phenibut to cross the blood brain Although the calming action is similar to other GABA agonists it acts on GABAb receptor.
Theanine only has weak affinity for the glutamate receptor on post-synaptic cells. Rather, its primary effect seems to increase the overall level of the brain inhibitory transmitter GABA
Antihistamines Are sedative but dont produce high amounts of euphoria
Melatonin is also a sedative but not that euphoric
Diethyl ether acts on GABA
gamma-Amino-beta-hydroxybutyric acid (GABOB), also known as gamibetal or buxamin, is a derivative of the neurotransmitter GABA the effects are GHB like its a dieatary supplement found on the net.
opiate/opioid describes any of the narcotic opioid alkaloids opioid receptor agonist – its main effect is binding to and activating the μ-opioid receptors in the central nervous system
Sinomenine or Cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum Sinomenine is a morphinan derivative, related to opioids such as levorphanol
Kratom primary pharmacology is mediated by the alkaloids 7-hydroxymitragynine and mitragynine
Picralima nitida alkaloids- akuammidine and -akuammigine, were found to be potent μ-opioid agonists
The Calabar bean is the seed of a leguminous plant Eseroline is a drug which acts as an opioid agonist It is a metabolite of the acetylcholinesterase inhibitor physostigmine
Salvia divinorum salvinorin A is a potent and selective κ-Opioid (kappa-Opioid) receptor agonist By mass, salvinorin A "is the most potent naturally occurring hallucinogen
Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors when taken with Prilosec Omeprazole above 30 mg produces typical opiate effects.
Poppy seed tea contains codeine morphine thebain
Protopine is a benzylisoquinoline alkaloid occurring in Argemone mexicana and corydalis tubers and other plants of the family papaveraceae. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an opioid analgesic
psychedelic A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception
Elemi oil Canarium luzonicum Ensure room is well ventilated when using Elemi Oil and do not ingest as misuse can lead to psychedelic experiances similar to a cross between mescaline and LSD
Morning glory contains lsa look it up many plants contain it
dextromethorphan look it up
